Seminars & Lectures
Guest Speakers
| Date YYYY/MM/DD | Guest Speaker |
|---|---|
| 2023/12/12 | Guest speaker: Prof. and GEoPD president Katerina Markoupolou Title: DBS and Genetics of Parkinson’s Disease – A Window into Disease Pathophysiology. |
| 2024/05/13 | Presentations for special guests: 1. Introduction - (Dr. Christine Klein) 2. Introduction to the MDSGene database (with LRRK2 as an example) - (Mirja Thomsen) 3. Genetic and environmental LRRK2 modifiers - (Dr. Joanne Trinh, Dr. Theresa Lueth) 4. Rostock International Parkinson's Disease Study (ROPAD) - (Dr. Ana Westenberger) 5. Genetic basis of age-related penetrance in XDP - (Shela Algodon) 6. Modelling disease: patient-derived iPSC-based models of PD - (Dr. Linn Streubel-Gallasch). |
| 2024/05/28 | Guest speaker: Dr. Justin Lee from the Institute for Basic Science, South Korea Title: Astrocytic hemoglobin is a H2O2-decomposing peroxidase and a therapeutic target for Alzheimer’s disease and ischemic stroke. |
| 2024/08/13 | Guest speaker: Dr. Björn-Hergen Laabs, Institute of Medical Biometry and Statistics, University of Lübeck Title: Dos and don'ts in Excel when working with a statistician - A (self)-ironic summary. |
| 2024/08/22 | Guest speaker: Dr. Zih-Hua Fang, GP2 - Lead Monogenic Data Analysis, German Center for Neurodegenerative Diseases Title: Ongoing work in the Global Parkinson's Genetics Program. |
| 2024/09/17 | Guest speaker: Dr. Madiha Malik, Institute of Pharmacy, University of Kiel Title: Breath-taking Discoveries: Unveiling the Diagnostic Potential of Exhaled Breath Analysis in Clinical Settings. |
| 2024/12/10 | Guest speaker: Dr. Peter Heutink, German Center for Neurodegenerative Diseases (DZNE), University of Tübingen. Title: Translating genetic hits to drug targets. |
| 2024/12/10 | Guest speaker: Dr. M. Leonor Bustamante, Human Genetics Program, ICBM and Department of Psychiatry and Mental Health, Title: Update on the Universidad de Chile-Universität zu Lüebeck collaboration on monogenic Parkinson´s disease. |
| 2024/12/10 | Guest speaker: Steffi Spitznagel, Private Client lawyer, International Arbitration Specialist, CEO of Global Resolutions Group, Ltd., Title: A New Calling for Justice in Healthcare? |
Seminars
| Date YYYY/MM/DD | Research section & presenter (Progress Report) | Presentation title (Progress Report) | Research section & presenter | Paper & DOI (Journal Club) |
|---|---|---|---|---|
| 2023/11/21 | Applied Stem Cell Biology, Dr. Linn Streubel-Gallasch | The retromer and seeding assay projects - Update | - | - |
| 2023/11/28 | Integrative Omics in Parkinson Disease, Carolin Gabbert | Identifying the genetic cause in Norwegian families with Parkinson’s disease | Integrative Omics in Parkinson Disease, Theresa Lüth | A blood-based marker of mitochondrial DNA damage in Parkinson’s disease, 10.1126/scitranslmed.abo1557 |
| 2023/12/07 | - | - | Genetics of Rare Diseases, Kaja Schröder | De novo retinoic acid receptor beta (RARB) variant associated with microphthalmia and dystonia, 10.1016/j.ejmg.2023.104802 |
| 2024/01/09 | Integrative Omics in Parkinson Disease, Dr. Joanne Trinh | Overview of present and future projects in the Integrative Omics research group | - | - |
| 2024/01/16 | Genetics of Rare Diseases, Aida Diaw | Tissue-specific imprinting of SGCE and expressional changes in dystonia | - | - |
| 2024/01/23 | - | - | Applied Stem Cell Biology, Dr. Linn Streubel-Gallasch | Propagative α-synuclein seeds as serum biomarkers for synucleinopathy, 10.1038/s41591-023-02358-9 |
| 2024/02/06 | Molecular Mechanisms of Movement Disorders, Arian Hach | Progress on PRKN Exon 2 deletion project | - | - |
| 2024/02/20 | Translational Neurogenetics, Dr. Christine Klein | Neurogenetics in the Clinic | - | - |
| 2024/03/05 | Applied Stem Cell Biology, Hannah Wimmerstedt | Differentiation and Characterization of Astrocytes | - | - |
| 2024/03/12 | Genetics of Rare Diseases, Dr. Katja Lohmann | Updates from the group - Molecular Genetics of Rare Diseases | Integrative Omics in Parkinson Disease, Dr. Joanne Trinh | A pathogenic variant in RAB32 causes autosomal dominant Parkinson’s disease and activates LRRK2 kinase, 10.1101/2024.01.17.24300927 |
| 2024/04/02 | Integrative Omics in Parkinson Disease, Carolin Gabbert | The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease | Translational Neurogenetics, Dr. Maria Leila Doquenia | Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease, 10.1038/s41588-023-01584-8 |
| 2024/04/09 | Molecular Mechanisms of Movement Disorders, Arian Hach | Remaining Parkin function & later AAO in homozygous PRKNdelEx2 carriers | - | - |
| 2024/04/16 | Translational Neurogenetics, Dr. Cholpon Shambetova | Report from Kyrgyzstan: Training and Progress in Building a New Cohort | Molecular Mechanisms of Movement Disorders, Dr. Aleksandar Rakovic | A mutational atlas for Parkin proteostasis, 10.1038/s41467-024-45829-4 |
| 2024/04/23 | Applied Stem Cell Biology, Letizia Santinelli | Investigation of the morphological and molecular effect of the phosphatase PTEN in primary murine Schwann cells | Genetics of Rare Diseases, Dr. Katja Lohmann | Dissecting genetic architecture of rare dystonia: genetic, molecular and clinical insights, 10.1136/jmg-2022-109099 |
| 2024/04/30 | Integrative Omics in Parkinson Disease, Joshua Laß | Mid-point seminar for PhD thesis | Applied Stem Cell Biology, Dr. Linn Streubel-Gallasch | MDS-ES FOCUSED WORKSHOP: Diagnostic and Progression Biomarkers in Parkinson’s Disease and Atypical Parkinsonism |
| 2024/05/07 | Genetics of Rare Diseases, Pin-Jui Kung | Elevated TAOK1 Levels in Plasma-Derived Extracellular Vesicles: A Diagnostic Marker for Cognitive Decline in Parkinson’s Disease Dementia and Alzheimer’s Disease | - | - |
| 2024/05/30 | Functional Genetics of Movement Disorders, Dr. Ana Westenberger | Rostock International Parkinson's Disease Study (ROPAD) | - | - |
| 2024/06/06 | Translational Neurogenetics, Dr. Christine Klein | New biological classifications of Parkinson's disease | - | - |
| 2024/06/13 | Molecular Mechanisms of Movement Disorders, Kerstin Tanzer | Progress Report on the DYT-TOR1A Project | Translational Neurogenetics, Dr. Karen Grütz | Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing, 10.1016/j.nbd.2023.106367 |
| 2024/06/25 | Applied Stem Cell Biology, Dr. Linn Streubel-Gallasch | Update: seed amplification assay and extracellular vesicle isolation | - | - |
| 2024/07/04 | - | - | Genetics of Rare Diseases, Lena Nothacker | eIF2α phosphorylation evokes dystonia-like movements with D2-receptor and cholinergic origin and abnormal neuronal connectivity, 10.1101/2024.05.14.594240 |
| 2024/07/18 | Integrative Omics in Parkinson Disease, André Fienemann | Optical genome mapping and long-read sequencing of structural variants in Parkinson’s disease-related induced pluripotent stem cells | - | - |
| 2024/07/23 | Applied Stem Cell Biology, Dr. Philip Seibler | Annual lab safety instructions | Molecular Mechanisms of Movement Disorders, Arian Hach | Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset, 10.1038/s41467-024-48961-3 |
| 2024/08/27 | Genetics of Rare Diseases, Dr. Katja Lohmann | Update of research section projects | - | - |
| 2024/09/23 | Integrative Omics in Parkinson Disease, Carolin Gabbert | Gene-environment modifiers in Parkinson’s disease | - | - |
| 2024/10/10 | Translational Neurogenetics, Dr. Christine Klein | Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model | Translational Neurogenetics, Alexander Balck | Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model" (doi: 10.1016/j.neuron.2024.07.013) |
| 2024/10/10 | Applied Stem Cell Biology, Dr. Philip Seibler | Modeling Lewy body disease with SNCA triplication iPSC-derived cortical organoids and identifying therapeutic drugs". | Applied Stem Cell Biology, Letizia Santinelli | Modeling Lewy body disease with SNCA triplication iPSC-derived cortical organoids and identifying therapeutic drugs" (doi: 10.1126/sciadv.adk3700). |
| 2024/10/14 | Translational Neurogenetics, Dr. Christine Klein | Biallelic NAA60 variants with impaired N-terminal acetylation capacity cause autosomal recessive primary familial brain calci cations". | Translational Neurogenetics, Max Brand | Biallelic NAA60 variants with impaired N-terminal acetylation capacity cause autosomal recessive primary familial brain calci cations" (doi: 10.1038/s41467-024-46354-0). |
| 2024/11/19 | Translational Neurogenetics, Dr. Christine Klein | The role of dopaminergic medication and specific pathway alterations in idiopathic and PRKN/PINK1-mediated Parkinson's diseache. | Translational Neurogenetics, Alexander Balck | - |
| 2024/11/28 | Integrative Omics in Parkinson Disease, Dr. Joanne Trinh | Single Cell RNA Sequencing of frozen human post-mortem brain. | Integrative Omics in Parkinson Disease, Joshua Laß | - |
| 2024/12/03 | - | Role of the immune system in dystonia | - | - |
| 2024/12/03 | Translational Neurogenetics, Dr. Christine Klein | First Evidence for Disease-Modifying Treatment of SLC20A2-Related Primary Familial Brain Calcification. | Translational Neurogenetics, Alexander Balck | - |
| 2025/01/09 | Genetics of Rare Diseases, Dr. Katja Lohmann | First Evidence for Disease-Modifying Treatment of SLC20A2-Related Primary Familial Brain Calcification. | Genetics of Rare Diseases, Linn Welzel | - |
| 2025/01/09 | Genetics of Rare Diseases, Dr. Katja Lohmann | First Evidence for Disease-Modifying Treatment of SLC20A2-Related Primary Familial Brain Calcification. | Genetics of Rare Diseases, Linn Welzel | - |
| 2025/01/23 | Integrative Omics in Parkinson Disease, Dr. Joanne Trinh | Genomic analysis of early-onset Parkinson's disease using long-read sequencing and optical genome mapping. | Integrative Omics in Parkinson Disease, André Fienemann | - |
| 2025/01/28 | Translational Neurogenetics, Dr. Christine Klein | PD prevalence study in Kyrgyzstan: a village-based pilot. | Translational Neurogenetics, Cholpon Shambetova | - |