|Phone number:||+49 451 3101 7493|
Postdoctoral fellow of the "Lübeck Interdisciplinary Platform for Genome Analytics" (LIGA), Institutes of Neurogenetics & for Integrative and Experimental Genomics, University of Lübeck
Bioinformatics; Data analysis, especially from next-generation sequencing data
2002 – 2005 Bachelor student in Computational Life Science, University of Lübeck, Germany
2006 – 2008 Master student in Bioinformatics, Free University Berlin, Germany
2008 - 2012 PhD student in the group “Algorithmic Computational Biology” at the Centrum Wiskunde & Informatica, i.e. the Dutch National Research Institute for Mathematics and Computer Science in Amsterdam, the Netherlands
Dec. 2012 PhD degree at Free University Amsterdam, the Netherlands
Oct. 2005 - Nov. 2005 Intern at the Max Delbrück Center for Molecular Medicine Berlin-Buch
2005 – 2008 Bioinformatics research scientist at Charité University Medicine Berlin
2010 – 2011 Scientific visitor at INRIA Rennes, France
2012 – 2015 Post-doctoral researcher at the chair of “Genome Informatics”, Institute of Human Genetics, University of Duisburg-Essen
2015 – present Post-doctoral researcher of the “Lübeck Interdisciplinary Platform for Genome Analytics” (LIGA), Institutes of Neurogenetics & for Integrative and Experimental Genomics, University of Lübeck
2009 Best Poster Award Runner Up, International Society for Computational Biology (ISCB) Student Council Symposium, Stockholm, Sweden
2011 Égide scholarship for scientific stay at INRIA Rennes from 12/2010 to 05/2011
2012 Featured Nucleic Acids Research article of July 2012: Top 5% of papers in terms of originality, significance and scientific excellence
2008 - 2012 Treasurer and board member of the Regional Student Group Netherlands
C. M. Lill, F. Luessi, A. Alcina, E. A. Sokolova, N. Ugidos, B. de la Hera, L. Guillot-Noël, S. Malhotra, E. Reinthaler, B.-M. M. Schjeide, J. Y. Mescheriakova, A. Mashychev, I. Wohlers et al. Genome-wide significant association with seven novel multiple sclerosis risk loci. J. Med. Genet. 52 (12):848-55, 2015.
R. Andonov, H. Djidjev, G. W. Klau, M. Le Boudic-Jamin, I. Wohlers. Automatic Classification of Protein Structure Using the Maximum Contact Map Overlap Metric. Algorithms, Special issue Algorithmic Themes in Bioinformatics, 8(4):850-869, 2015.
P. Johansson, A. Bergmann, S. Rahmann, I. Wohlers, R. Scholtysik, M. Przekopowitz, M. Seifert, G. Tschurtschenthaler, G. Webersinke, U. Jäger, R. Siebert, L. Klein-Hitpass, U. Dührsen, J. Dürig and R. Küppers. Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. To appear in Int J Cancer. 138(1):121-124, 2016.
T. Pietsch, I. Wohlers, T. Goschzik, V. Dreschmann, D. Denkhaus, E. Dörner, S. Rahmann, and L. Klein-Hitpass. Supratentorial ependymomas of childhood carry C11orf95–RELA fusions leading to pathological activation of the NF-κB signaling pathway. Acta Neuropathol. 127(4):609-11, 2014.
M. El-Kebir*, T. Marschall*, I. Wohlers*, M. Patterson, J. Heringa, A. Schönhuth, and G. W. Klau. Mapping proteins in the presence of paralogs using units of coevolution. BMC Bioinformatics 14(15):1-9, 2013.
I. Wohlers, R. Andonov and G. W. Klau. DALIX: Optimal DALI protein structure alignment. IEEE/ACM Trans. Comput. Biology Bioinform. 10(1):26-36, 2013.
I. Wohlers, N. Malod-Dognin, R. Andonov, and G. W. Klau. CSA: comprehensive comparison of pairwise protein structure alignments. Nucleic Acids Res, 40(Web Server issue):303-309, 2012. Featured article of July 2012: Top 5% of papers in terms of originality, significance and scientific excellence.
I. Wohlers, R. Andonov, and G. W. Klau. Algorithm engineering for optimal alignment of protein structure distance matrices. Optimization Letters, 5(3):421-433, 2011.
I. Wohlers, F. S. Domingues, and G. W. Klau. Towards optimal alignment of protein structure distance matrices. Bioinformatics, 26(18):2273-2280, 2010.
I. Wohlers*, H. Stachelscheid*, J. Borstlap, K. Zeilinger, and J. C. Gerlach. The Characterization Tool: A knowledge-based stem cell, differentiated cell, and tissue database with a web-based analysis front-end. Stem Cell Res, 3(2-3):88-95, 2009.
Articles in Refereed Conference Proceedings / Selected Abstracts:
I. Wohlers, M. Le Boudic-Jamin, H. Djidjev, G. W. Klau and R. Andonov. Exact protein structure classification using the maximum contact map overlap metric. In Algorithms for Computational Biology (AlCoB), pages 262-273, 2014.
I. Wohlers, N. Malod-Dognin, R. Andonov, and G. W. Klau. CSA : Comparaison compréhensible d’alignement de paires de structures de protéines. In Proceedings of JOBIM, p.201-208, 2012 (in french).
A. Mucherino, I. Wohlers, G. W. Klau, and R. Andonov. Sparsifying distance matrices for protein-protein structure alignments. In Cologne-Twente Workshop on graphs and combinatorial optimization (CTW), pages 211-214, 2011.
I. Wohlers, L. Petzold, F. S. Domingues, and G. W. Klau. Aligning protein structures using distance matrices and combinatorial optimization. In German Conference on Bioinformatics (GCB), volume 157 of LNI, pages 33-43. GI, 2009.
I. Wohlers, L. Petzold, F. S. Domingues, and G.W. Klau. PAUL: protein structural alignment using integer linear programming and Lagrangian relaxation. BMC Bioinformatics, 10(S-13):0, 2009.