Inken Wohlers
Inken Wohlers, PhD
Postdoctoral fellow
Phone number:+49 451 3101 7493

Current Position:

Postdoctoral fellow of the "Lübeck Interdisciplinary Platform for Genome Analytics" (LIGA), Institutes of Neurogenetics & for Integrative and Experimental Genomics, University of Lübeck

Research Focus:

Bioinformatics; Data analysis, especially from next-generation sequencing data

Education & Scientific training

Education:

2002 – 2005     Bachelor student in Computational Life Science, University of Lübeck, Germany

2006 – 2008     Master student in Bioinformatics, Free University Berlin, Germany

2008 - 2012     PhD student in the group “Algorithmic Computational Biology” at the Centrum Wiskunde & Informatica, i.e. the Dutch National Research Institute for Mathematics and Computer Science in Amsterdam, the Netherlands

Dec. 2012     PhD degree at Free University Amsterdam, the Netherlands

 

Scientific training:

Oct. 2005 - Nov. 2005     Intern at the Max Delbrück Center for Molecular Medicine Berlin-Buch

2005 – 2008     Bioinformatics research scientist at Charité University Medicine Berlin

2010 – 2011     Scientific visitor at INRIA Rennes, France

2012 – 2015     Post-doctoral researcher at the chair of “Genome Informatics”, Institute of Human Genetics, University of Duisburg-Essen

2015 – present     Post-doctoral researcher of the “Lübeck Interdisciplinary Platform for Genome Analytics” (LIGA), Institutes of Neurogenetics & for Integrative and Experimental Genomics, University of Lübeck

Awards & Memberships

Awards:

2009     Best Poster Award Runner Up, International Society for Computational Biology (ISCB) Student Council Symposium, Stockholm, Sweden

2011     Égide scholarship for scientific stay at INRIA Rennes from 12/2010 to 05/2011

2012     Featured Nucleic Acids Research article of July 2012: Top 5% of papers in terms of originality, significance and scientific excellence

 

Memberships:

2008 - 2012     Treasurer and board member of the Regional Student Group Netherlands

 

Journal Articles

 

Journal Articles

  1. C. M. Lill, F. Luessi, A. Alcina, E. A. Sokolova, N. Ugidos, B. de la Hera, L. Guillot-Noël, S. Malhotra, E. Reinthaler, B.-M. M. Schjeide, J. Y. Mescheriakova, A. Mashychev, I. Wohlers et al. Genome-wide significant association with seven novel multiple sclerosis risk loci. J. Med. Genet. 52 (12):848-55, 2015.

  2. R. Andonov, H. Djidjev, G. W. Klau, M. Le Boudic-Jamin, I. Wohlers. Automatic Classification of Protein Structure Using the Maximum Contact Map Overlap Metric. Algorithms, Special issue Algorithmic Themes in Bioinformatics, 8(4):850-869, 2015.

  3. P. Johansson, A. Bergmann, S. Rahmann, I. Wohlers, R. Scholtysik, M. Przekopowitz, M. Seifert, G. Tschurtschenthaler, G. Webersinke, U. Jäger, R. Siebert, L. Klein-Hitpass, U. Dührsen, J. Dürig and R. Küppers. Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. To appear in Int J Cancer. 138(1):121-124, 2016.

  4. T. Pietsch, I. Wohlers, T. Goschzik, V. Dreschmann, D. Denkhaus, E. Dörner, S. Rahmann, and L. Klein-Hitpass. Supratentorial ependymomas of childhood carry C11orf95–RELA fusions leading to pathological activation of the NF-κB signaling pathway. Acta Neuropathol. 127(4):609-11, 2014.

  5. M. El-Kebir*, T. Marschall*, I. Wohlers*, M. Patterson, J. Heringa, A. Schönhuth, and G. W. Klau. Mapping proteins in the presence of paralogs using units of coevolution. BMC Bioinformatics 14(15):1-9, 2013.

  6. I. Wohlers, R. Andonov and G. W. Klau. DALIX: Optimal DALI protein structure alignment. IEEE/ACM Trans. Comput. Biology Bioinform. 10(1):26-36, 2013.

  7. I. Wohlers, N. Malod-Dognin, R. Andonov, and G. W. Klau. CSA: comprehensive comparison of pairwise protein structure alignments. Nucleic Acids Res, 40(Web Server issue):303-309, 2012. Featured article of July 2012: Top 5% of papers in terms of originality, significance and scientific excellence.

  8. I. Wohlers, R. Andonov, and G. W. Klau. Algorithm engineering for optimal alignment of protein structure distance matrices. Optimization Letters, 5(3):421-433, 2011.

  9. I. Wohlers, F. S. Domingues, and G. W. Klau. Towards optimal alignment of protein structure distance matrices. Bioinformatics, 26(18):2273-2280, 2010.

  10. I. Wohlers*, H. Stachelscheid*, J. Borstlap, K. Zeilinger, and J. C. Gerlach. The Characterization Tool: A knowledge-based stem cell, differentiated cell, and tissue database with a web-based analysis front-end. Stem Cell Res, 3(2-3):88-95, 2009.

Articles in Refereed Conference Proceedings / Selected Abstracts:

  1. I. Wohlers, M. Le Boudic-Jamin, H. Djidjev, G. W. Klau and R. Andonov. Exact protein structure classification using the maximum contact map overlap metric. In Algorithms for Computational Biology (AlCoB), pages 262-273, 2014.

  2. I. Wohlers, N. Malod-Dognin, R. Andonov, and G. W. Klau. CSA : Comparaison compréhensible d’alignement de paires de structures de protéines. In Proceedings of JOBIM, p.201-208, 2012 (in french).

  3. A. Mucherino, I. Wohlers, G. W. Klau, and R. Andonov. Sparsifying distance matrices for protein-protein structure alignments. In Cologne-Twente Workshop on graphs and combinatorial optimization (CTW), pages 211-214, 2011.

  4. I. Wohlers, L. Petzold, F. S. Domingues, and G. W. Klau. Aligning protein structures using distance matrices and combinatorial optimization. In German Conference on Bioinformatics (GCB), volume 157 of LNI, pages 33-43. GI, 2009.

  5. I. Wohlers, L. Petzold, F. S. Domingues, and G.W. Klau. PAUL: protein structural alignment using integer linear programming and Lagrangian relaxation. BMC Bioinformatics, 10(S-13):0, 2009.

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