Christina Lill
Christina Lill, MD, MS
Research section leader
Phone number:+49 451 3101 7495

Current Position:

Postdoctoral fellow and leader of the “Genetic and Molecular Epidemiology" Research Group, Institute of Neurogenetics; University of Lübeck

Research Focus:

Genetic and molecular epidemiology, identification and characterization of genetic risk factors for neurodegenerative and neuroinflammatory diseases, gene-environment interactions, epigenetics

Education & Scientific training

Education:

1999 – 2005     Studies in medicine, Westfälische Wilhelms University, Münster, Ludwig Maximilians University, München, with internships at the Harvard Medical School, Boston, USA, the Yale New Haven Hospital, New Haven, USA, and the Hôpital de la Pitié-Salpêtrière, Paris, France

2006 – 2007     MD thesis research fellowship at the Massachusetts Institute for Neurodegenerative Disease, Harvard Medical School, Charlestown, USA

2012     MD thesis (Dr. med., title: “Identifikation neuer Parkinson-Gene durch Data-Mining und systematische Metaanalysen genetischer Assoziationsstudien”)

2010 – 2015     Postgraduate Master’s program in epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics, Johannes Gutenberg University, Mainz (title of thesis: “Integrated analysis of genetic, environmental and lifestyle factors involved in Parkinson’s disease”)

 

Scientific training:

2008 – 2009     Resident, Dept. of Neurology, Charité University Medicine, Berlin

2010 – 2011     Resident, Dept. of Neurology, Johannes Gutenberg University, Mainz

2012 – Nov. 2014     Research fellow, Neuropsychiatric Genetics Group, Dept. of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin

Dec. 2014 – present     Research fellow, Institute of Neurogenetics; University of Lübeck

Awards & Memberships

Awards:

1999 – 2005     Scholarship of the German National Merit Foundation (Studienstiftung des deutschen Volkes)

2000 – 2005     Scholarship of the e-fellows.net GmbH & Co KG

2006 – 2007     MD thesis research scholarship (Promotionsstipendium) of the German Academic Exchange Service (Deutscher Akademischer Austauschdienst)

2009               Travel award of the Felgenhauer foundation

2015               Travel award of the GlaxoSmithKline foundation

2015               Renate Maaß Award for Brain Research

 

Memberships:

Co-chair of the Movement Disorder Society Task Force on Epidemiology

Editorial boards of Brain Disorders & Therapy, Gene, Meta Gene

Extended Steering Group of the Berlin Aging Study II (BASE II)

Genetic Epidemiology of Parkinson’s Disease (GEO-PD) Consortium,                                                                         German Society of Humangenetics

International Multiple Sclerosis Genetics Consortium (IMSGC)

Reviewer Activities

Journals                       

e.g. American Journal of Epidemiology, BMC Neurology, European Journal of Clinical Investigation, Journal of Clinical Investigation, Journal of Neurological Sciences, European Journal of Neurology, Gene, Human Genetics, Human Immunology, Human Mutation, International Journal of Alzheimer’s Disease, Journal of Clinical Investigation, Journal of Neural Transmission, Journal of Neurology, Journal of Neurology & Neurophysiology, Mitochondrion, Movement Disorders, Neurobiology of Aging, Neurogenetics, PLoS Genetics, PLoS ONE, Scientific Reports, The Pharmacogenomics Journal

Foundations                

Dutch Alzheimer’s Society, Fundació La Marató de TV3 Spain, Medical Research Council (MRC) UK, Parkinson's UK, Research Foundation - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen)

PhD thesis                   

Jury member for PhD thesis at the Department of Neurosciences, KU Leiden, Belgium, 2014

Research Funding

Title: “Identification and independent validation of potential genetic risk factors for Multiple Sclerosis”
Co-Principal Investigator
Agency: Charité University Medicine 
Funding period: Jan. 2009-Dec. 2009
Amount: 30,000 €

Title: “MsGene: A Meta-Analysis Database for Genetic Association Studies in Multiple Sclerosis”
Co-Principal Investigator
Agency: EMD-Serono (USA) 
Funding period: 2010 - 2013
Amount: 112,138 €

Title: “A Meta-Analysis Database for Genetic Association Studies in Amyotrophic Lateral Sclerosis”
Co-Principal Investigator
Agency: Prize4Life (USA) 
Funding period: 2010 - 2014
Amount: 95,066 €

Title: "Implementation of PD GWAS meta-analysis results on the PDGene database”
Co-Principal Investigator
Agency: MJFF (USA)
Funding period: 2011 - 2013
Amount: 9,045 €

Title: “Continuation of AlzGene and Related Database Projects in the 'GWAS Era'
Co-Principal Investigator
Agency: BRF (USA)
Funding period: 2012 - 2014
Amount: 142,290 €

Title: “Infrastruktur- und karrierefördernde Maßnahme zugunsten Frau Dr. med. Christina Lill”
Agency: Possehl-Stiftung Lübeck 
Funding period: Feb. 2016 – Nov. 2016
Amount: 80,000 €

Title: “Untersuchung von Gen-Umwelt-Wechselwirkungen und Entwicklung eines klinischen Algorithmus zur Vorhersage der idiopathischen Parkinson-Krankheit”
Principal Investigator
Agency: Universität zu Lübeck 
Funding period: Jan. 2016 – Dez. 2017
Amount: 74,796 €

Publications

Summary:

All publications: 47

Publications as (shared) first author: 26

Citations: 1285 (as of January 14th, 2016, source: Scopus database [http://www.scopus.com])

Cumulative impact factors: 394.5

Original publications as (shared) first author:

  1. Lill CM, Liu T, Norman K, Meyer A, Steinhagen-Thiessen E, Demuth I, Bertram L. Genetic burden analyses of phenotypes relevant to aging in the Berlin Aging Study II (BASE-II). Gerontology, in press; IF=3.1

  2. Schrewe L, Lill CM, Liu T, Salmen A, Gerdes LA, Guillot-Noel L, Akkad D, Blaschke P, Graetz C, Hoffjan S, Kroner A, Demir S, Böhme A, Rieckmann P, ElAli A, Hagemann N, Hermann D, Cournu-Rebeix I, Zipp F, Kümpfel T, Buttmann M, Zettl UK, Fontaine B, Bertram L, Gold R, Chan A. Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS. J Neuroinflammation, 2015;16;12(1):234; equally contributing; IF=5.4

  3. Lill CM, Luessi F, Alcina A, Sokolova EA, Ugidos N, de la Hera B, Guillot-Noël L, Malhotra S, Reinthaler E, Schjeide BM, Mescheriakova JY, Mashychev A, Wohlers I, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Astobiza I, Blaschke P, Boyko AN, Buttmann M, Chan A, Dörner T, Epplen JT, Favorova OO, Fedetz M, Fernández O, García-Martínez A, Gerdes LA, Graetz C, Hartung HP, Hoffjan S, Izquierdo G, Korobko DS, Kroner A, Kubisch C, Kümpfel T, Leyva L, Lohse P, Malkova NA, Montalban X, Popova EV, Rieckmann P, Rozhdestvenskii AS, Schmied C, Smagina IV, Tsareva EY, Winkelmann A, Zettl UK, Binder H, Cournu-Rebeix I, Hintzen R, Zimprich A, Comabella M, Fontaine B, Urcelay E, Vandenbroeck K, Filipenko M, Matesanz F, Zipp F, Bertram L. Genome-wide significant association with seven novel multiple sclerosis risk loci. J Med Genet, 2015;52(12):848-55; IF=6.3

  4. Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J, Partch A, Restagno G, Rujescu D, Schnack C, Shaw CE, Shaw PJ, Tumani H, Tysnes OB, Valladares O, Silani V, van den Berg LH, van Rheenen W, Veldink JH, Lindenberger U, Steinhagen-Thiessen E, SLAGEN Consortium, Teipel S, Perneczky R, Hakonarson H, Hampel H, von Arnim CAF, Olsen JH, Van Deerlin VM, Al-Chalabi A, Toft M, Ritz B, Bertram L. The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease. Alzheimers Dement, 2015 Apr 29. [Epub ahead of print]; IF=17.5

  5. Lill CM, Hansen J, Olsen JH, Binder H, Ritz B, Bertram L. Impact of Parkinson’s Disease Risk Loci on Age at Onset. Mov Disord, 2015 Apr 25. [Epub ahead of print]; IF=5.6

  6. Hooli BV§, Lill CM§, Mullin K, Qiao D, Lange C, Bertram L, Tanzi RE. PLD3 gene variants and Alzheimer's disease. Nature, 2015 Apr 1 [Epub ahead of print]; doi:10.1038/nature14040 §equally contributing; IF=42.4

  7. Ahmed I§, Lee PC§, Lill CM§, Searles Nielsen S§, Artaud F, Gallagher LG, Loriot MA, Mulot C, Nacfer M, Liu T, Biernacka JM, Armasu S, Anderson K, Farin FM, Lassen CF, Hansen J, Olsen JH, Bertram L, Maraganore DM, Checkoway H, Ritz B, Elbaz A. Lack of Replication of the GRIN2A-by-Coffee Interaction in Parkinson Disease. PLoS Genet, 2014;10(11):e1004788 §equally contributing; IF=8.2

  8. Lill CM, Schilling M, Ansaloni S, Schröder J, Jaedicke M, Luessi F, Schjeide BM, Mashychev A, Graetz C, Akkad DA, Gerdes LA, Kroner A, Blaschke P, Hoffjan S, Winkelmann A, Dörner T, Rieckmann P, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Zipp F, Bertram L. Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis. Neurogenetics, 2014,15(2):129-34; IF=2.7

  9. Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández O, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L, Zipp F. MANBA, CXCR5, SOX8, RPS6KB1, and ZBTB46 are genetic risk loci for multiple sclerosis. Brain, 2013;136(Pt 6):1778-82; IF=10.2

  10. Lill CM, Günther-Kunkel K, Hoch H, Paul F, Grond-Ginsbach C, Hausser I, Zipp F. Bilateral vertebral artery dissection in a patient with agenesis of both ICAs and ultrastructural connective tissue aberrations. Neurology, 2013;80(15):1442-3; IF=8.3

  11. Broer L§, Lill CM§, Schuur M§, Amin N, Roehr JT, Bertram L, Ioannidis JPA, van Duijn CM. Distinguishing true from false positives in genomic studies: p-values. Eur J Epidemiol, 2013;28(2):131-8 §equally contributing; IF=5.2

  12. Lill CM, Schjeide BM, Graetz C, Liu T, Damotte V, Akkad DA, Blaschke P, Gerdes LA, Kroner A, Luessi F, Cournu-Rebeix I, Hoffjan S, Winkelmann A, Touze E, Pico F, Corcia P, Otaegui D, Antigüedad A, Alcina A, Comabella M, Montalban X, Olascoaga J, Matesanz F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Rieckmann P, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Fontaine B, Zipp F, Vandenbroeck K, Bertram L. Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk. J Med Genet, 2013;50(3):140-3; IF=5.6

  13. Lill CM, Liu T, Schjeide B-MM, Roehr JT, Akkad DA, Damotte V,  Alcina A, Ortiz MA, Arroyo R, Lopez de Lapuente A, Blaschke P, Winkelmann A, Gerdes L-A, Luessi F, Fernadez O, Izquierdo G,  Antigüedad A, Hoffjan S, Cournu-Rebeix I, Gromöller S, Faber H, Liebsch M, Meissner E, Chanvillard C, Touze E, Pico F, Corcia P, ANZgene Consortium, Dörner T, Steinhagen-Thiessen E, Baeckman L, Heekeren HR, Li S-C, Lindenberger U, Chan A, Hartung H-P, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Fontaine B, Vandenbroeck K, Matesanz F, Urcelay E, Bertram L, Zipp F. Closing the case of APOE in multiple sclerosis: No association with disease risk in over 29,000 subjects. J Med Genet, 2012;49(9):558-62; IF=5.7

  14. Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide L, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP, 23andMe Inc., The Genetic Epidemiology of Parkinson’s Disease (GEO-PD) Consortium, The International Parkinson’s Disease Genomics Consortium (IPDGC), The Parkinson’s Disease GWAS Consortium, The Wellcome Trust Case Control Consortium 2 (WTCCC2), Young P, Tanzi RE, Koury MJ, Zipp F, Lehrach H, Ioannidis JPA, Bertram L. Comprehensive research synopsis and systematic meta-analyses in Parkinson’s disease genetics: The PDGene database. PLoS Genet, 2012; 8(3): e1002548; IF=8.5

  15. Lill CM§, Schjeide BM§, Akkad DA, Blaschke P, Winkelmann A, Gerdes LA, Hoffjan S, Luessi F, Fuczik E, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Bertram L, Zipp F. Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample. Neurogenetics, 2012;13(1):83-6 §equally contributing; IF=3.6

  16. Lill CM§, Abel O§, Bertram L, Al-Chalabi A. Keeping up with Genetic Discoveries in Amyotrophic Lateral Sclerosis: The ALSoD and ALSGene databases. Amyotroph Lateral Scler, 2011;12(4):238-49 §equally contributing; IF=3.1

  17. Chatzinasiou F§, Lill CM§, Kypreou K, Stefanaki I, Nicolaou V, Spyrou G, Evangelou E, Roehr JT, Kodela E, Katsambas A, Tsao H, Ioannidis JPA, Bertram L, Stratigos AJ. Comprehensive Field Synopsis and Systematic Meta-analyses of Genetic Association Studies in Cutaneous Melanoma. J Natl Cancer Inst, 2011;103(16):1227-35 §equally contributing; IF=13.8

  18. Lill CM, Schjeide BM, Roehr JT, Zauft U, Allen NC, Zipp F, McQueen MB, Kavvoura FK, Ioannidis JP, Khoury MJ, Tanzi RE, Bertram L. Correspondence to Sand et al. Critical reappraisal of a catechol-o-methyltransferase transversion variant in schizophrenia. Biol Psychiatry, 2010;67(7):e45-8; IF=8.7

  19. Lill CM, Hoch H, Dieste F-J, Vogel H-P, Zipp F, Paul F. Bilateral stroke following pituitary apoplexy. J Clin Neurosci, 2009;16(12):1670-3; IF=1.2

Original publications as co-author:

  1. Kypreou KP, Stefanaki I, Antonopoulou K, Karagianni F, Ntritsos G, Zaras A, Nikolaou V, Kalfa I, Hasapi V, Polydorou D, Gogas H, Spyrou GM, Bertram L, Lill CM, Ioannidis JPA, Antoniou C, Evangelou E, Stratigos AI. Prediction of melanoma risk in a Southern European population based on a weighted genetic risk score. J Invest Dermatol, in press; IF=7.2

  2. Dankowski T, Buck D, Andlauer TF, Antony G, Bayas A, Bechmann L, Berthele A, Bettecken T, Chan A, Franke A, Gold R, Graetz C, Haas J, Hecker M, Herms S, Infante-Duarte C, Jöckel KH, Kieseier BC, Knier B, Knop M, Kümpfel T, Lichtner P, Lieb W, Lill CM, Limmroth V, Linker RA, Loleit V, Meuth SG, Moebus S, Müller-Myhsok B, Nischwitz S, Nöthen MM, Paul F, Pütz M, Ruck T, Salmen S, Stangel M,  Stellmann JP, Strauch K, Stürner KH, Tackenberg B, Then Bergh F, Tumani H, Waldenberger M, Weber F, Wiendl H, Wildemann B, Zettl UK, Ziemann U, Zipp F, Hemmer B, Ziegler A, on behalf of the German Competence Network for Multiple Sclerosis (KKNMS). Successful replication of GWAS hits for multiple sclerosis in 10,000 Germans using the exome array. Genetic Epidemiol, 2015 Oct 26. doi: 10.1002/gepi.21933. [Epub ahead of print]; IF=2.6

  3. Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder TMC, Booth D, Buck D, Celius EG, Cotsapas C, D'alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Fugger L, Goris A, Gourraud PA, Graetz C, Hemmer B, Hillert J, International IBD Genetics Consortium (IIBDGC), Kockum I, Leslie S, Lill CM, Martinelli- Boneschi F, Oksenberg JR, Olsson T, Oturai A, Saarela J, Søndergaard HB, Spurkland A, Taylor B, Winkelmann J, Zipp F, Haines JL, Pericak-Vance MA, Spencer CCA, Stewart G, Hafler DA, Ivinson AJ, Harbo HF, Hauser SL, De Jager PL, Compston A, McCauley JL, Sawcer S, McVean G for the International Multiple Sclerosis Genetics Consortium. Class II HLA interactions modulate genetic risk for multiple sclerosis. Nat Genet, 2015 Oct;47(10):1107-13, IF=29.4

  4. Hoppmann N, Graetz C, Paterka M, Poisa-Beiro L, Larochelle C, Hasan M, Lill CM, Zipp F, Siffrin V. New candidates for CD4 T-cell pathogenicity in experimental neuroinflammation and multiple sclerosis. Brain, 2015 Feb 9. pii: awu408. [Epub ahead of print], IF=10.2

  5. Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, Plagnol V, Gibbs JR, Schulte C, Pankratz N, Sutherland M, Bertram L, Lill CM, DeStefano AL, Faroud T, Eriksson N, Tung JY, Edsall C, Nichols N, Brooks J, Arepalli S, Pliner H, Letson C, Heutink P, Martinez M, Gasser T, Traynor BJ, Wood N, Hardy J, Singleton AB; International Parkinson's Disease Genomics Consortium (IPDGC) and the Parkinson's Disease meta-analysis consortium. NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases. Neurobiol Aging, 2015;36(3):1605.e7-1605.e12; IF=4.9

  6. Antonopoulou K, Stefanaki I, Lill CM, Chatzinasiou F, Kypreou K, Karagianni F, Athanasiadis E, Spyrou GM, Ioannidis JP, Bertram L, Evangelou E, Stratigos AJ. Updated Field Synopsis and Systematic Meta-Analyses of Genetic Association Studies in Cutaneous Melanoma: The MelGene Database. J Invest Dermatol. 2015;135(4):1074-9; IF=6.4

  7. Athanasiadis EI, Antonopoulou K, Chatzinasiou F, Lill CM, Bourdakou MM, Sakellariou A, Kypreou K, Stefanaki I, Evangelou E, Ioannidis JP, Bertram L, Stratigos AJ, Spyrou GM. A web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools. Database, 2014 Nov 7;2014. doi: 10.1093/database/bau101; IF=4.5

  8. Schröder J, Ansaloni S, Schilling M, Liu T, Radke J, Jaedicke M, Schjeide BM, Mashychev A, Tegeler C, Radbruch H, Papenberg G, Düzel S, Demuth I, Bucholtz N, Lindenberger U, Li SC, Steinhagen-Thiessen E, Lill CM, Bertram L. MicroRNA-138 is a potential regulator of memory performance in humans. Front Hum Neurosci, 2014;8:501; IF=2.9

  9. Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R; International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI); 23andMe; GenePD; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); The Ashkenazi Jewish Dataset Investigator; Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); United Kingdom Brain Expression Consortium (UKBEC); Greek Parkinson's Disease Consortium; Alzheimer Genetic Analysis Group, Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet, 2014 46(9):989-93; IF=29.7

  10. Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF; Wellcome Trust Case Control Consortium 2 (WTCCC2); International IBD Genetics Consortium (IIBDGC), Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Søndergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelčić I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppä V, Liberatore G, Lie BA, Lill CM, Lindén M, Link J, Luessi F, Lycke J, Macciardi F, Männistö S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet, 2013;45(11):1353-60; IF=29.7

  11. Pichler I, Del Greco FM, Gögele M, Lill CM, Bertram L, Do CB, Eriksson N, Foroud T, Myers RH, PD GWAS Consortium, Nalls M, Keller MF, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, Benyamin B, Whitfield JB, Genetics of Iron Status Consortium, Pramstaller PP, Hicks AA, Thompson JR, Minelli C. Serum iron levels and the risk of Parkinson’s disease: a Mendelian randomization study. PLoS Med,2013;10(6):e1001462; IF=14.0

  12. International Multiple Sclerosis Genetics Consortium: Baranzini SE, Khankhanian P, Patsopoulos NA, Li M, Stankovich J, Cotsapas C, Søndergaard HB, Ban M, Barizzone N, Bergamaschi L, Booth D, Buck D, Cavalla P, Celius EG, Comabella M, Comi G, Compston A, Cournu-Rebeix I, D'alfonso S, Damotte V, Din L, Dubois B, Elovaara I, Esposito F, Fontaine B, Franke A, Goris A, Gourraud PA, Graetz C, Guerini FR, Guillot-Noel L, Hafler D, Hakonarson H, Hall P, Hamsten A, Harbo HF, Hemmer B, Hillert J, Kemppinen A, Kockum I, Koivisto K, Larsson M, Lathrop M, Leone M, Lill CM, Macciardi F, Martin R, Martinelli V, Martinelli-Boneschi F, McCauley JL, Myhr KM, Naldi P, Olsson T, Oturai A, Pericak-Vance MA, Perla F, Reunanen M, Saarela J, Saker-Delye S, Salvetti M, Sellebjerg F, Sørensen PS, Spurkland A, Stewart G, Taylor B, Tienari P, Winkelmann J, Zipp F, Ivinson AJ, Haines JL, Sawcer S, Dejager P, Hauser SL, Oksenberg JR. Network-Based Multiple Sclerosis Pathway Analysis with GWAS Data from 15,000 Cases and 30,000 Controls. Am J Hum Genet, 2013;92(6):854-65; IF=11.0

  13. Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Bertram L, Bozi M, Barcikowska M, Crosiers D, Clarke CE, Facheris MF, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon BS, Jamrozik Z, Krygowska-Wajs A, Lesage S, Lill CM, Lin JJ, Lynch T, Lichtner P, Lang AE, Libioulle C, Murata M, Mok V, Jasinska-Myga B, Mellick GD, Morrison KE, Meitnger T, Zimprich A, Opala G, Pramstaller PP, Pichler I, Park SS, Quattrone A, Rogaeva E, Ross OA, Stefanis L, Stockton JD, Satake W, Silburn PA, Strom TM, Theuns J, Tan EK, Toda T, Tomiyama H, Uitti RJ, Van Broeckhoven C, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Yomono HS, Yueh KC, Zhao Y, Gasser T, Maraganore D, Krüger R; on behalf of GEOPD consortium.. A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants. J Med Genet, 2012;49(11):721-6; IF=5.7

  14. Li X, Uemura K, Hashimoto T, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O. Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions. Neurobiol Dis, 2013;50:127-34; IF=5.6

  15. Sharma M, Ioannidis JPA, Aasly JO, Brice A, Van Broeckhoven C, Annesi G, Bertram L, Bozi M, Crosiers D, Clarke C, Facheris MF, Farrer M, Gispert S, Auburger G, Vilarino-Guell C, Garraux G, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon BS, Lesage S, Lill CM, Lin JJ, Lynch T, Lichtner P, Lang AE, Mok VCT, Jasinska-Myga B, Mellick GD, Morrison KE, Opala GM, Pramstaller PP, Pichler I, Park SS, Quattrone A, Rogaeva EA, Ross OA, Stefanis L, Stockton J, Satake W, Silburn P, Theuns J, Tan EK, Toda T, Tomiyama H, Uitti RJ, Wirdefeldt K, Wszolek ZK, Xiromerisiou G, Yueh KC, Zhao YI, Gasser T, Maraganore DM, Krüger R. Worldwide replication and heterogeneity in Parkinson’s disease genetic loci. Neurology,2012;79(7):659-67; IF=8.3

  16. Wallace BC, Small K, Brodley CE, Lau J, Schmid CH, Bertram L, Lill CM, Cohen J, Trikalinos TA. Towards Modernising the Systematic Review Pipeline: Efficiently Updating Live Synopses via Data Mining. Genet Med, 2012;14(7):663-9; IF=5.6

  17. Schjeide BM, Schnack C, Lambert J-C, Lill CM, Kirchheiner J, Tumani H, Otto M, Tanzi RE, Lehrach H, Amouyel P, von Arnim C, Bertram L. The role of CLU, CR1, and PICALM on Alzheimer's disease risk and CSF biomarker levels. Arch Gen Psychiatry, 2011;68(2):207-13; IF=12.0

  18. Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio. PLoS One, 2009;4(11):e7893; IF=4.4

  19. Dörr J, Bitsch A, Schmailzl KJG, Chan A, von Ahsen N, Hummel M, Varon R, Lill CM, Vogel H-P, Zipp F, Paul F. Severe cardiac failure in a multiple sclerosis patient following low-dose mitoxantrone treatment. Neurology, 2009;73(12):991-3; IF=8.2

  20. Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase. Mol Cell Neurosci, 2009;41(2):166-74; IF=3.6

  21. Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita A. N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. J Neurochem, 2009;108(2):350-60; IF=4.0

 

Reviews, commentaries:

  1. Lill CM & Bertram L. Probing the epigenome by EWAS: a new era in brain disease research. Mov Disord, 2015 Feb;30(2):197; IF=5.6

  2. Lill CM. Recent advances and future challenges in the genetics of multiple sclerosis. Front Neurol, 2014;5:130; IF=NA

  3. Lill CM & Bertram L. Developing the “next generation” of genetic association databases for complex diseases. Hum Mutat, 2012;33(9):1366-72; IF=5.2

  4. Lill CM & Zipp F. Das genetische Profil der Multiplen Sklerose: Risikogene und die „dunkle Materie“. Nervenarzt, 2012; 83(6):705-13; IF=0.8

  5. Lill CM & Bertram L. Towards Unveiling the Genetics of Neurodegenerative Diseases. Sem Neurol, 2011;31(5):531-41; IF=1.6

  6. Bertram L, Lill CM,Tanzi RE. The genetics of Alzheimer's disease: Back to the future. Neuron, 2010;68(2):270-81; IF=14.0

  7. Lill CM & Bertram L. Online-Datenbanken und systematische Metaanalysen komplex-genetischer Erkrankungen. Medizinische Genetik, 2010;22:235–41; IF=NA

 

Book chapters:

  1. Lill CM, Tanzi RE, Bertram L. Chap. 41: Genetics of Neurodegenerative Diseases. Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology,Academic Press/Elsevier Inc, 2011, Vol. 8, 719-736. Editors: Scott Brady, George Siegel, R. Wayne Albers and Donald Price.

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