front row, 4th from left: Director (Dept. of Neurology) Thomas Münte, Institute of Neurogenetics head Christine Klein, Vice Institute's head Katja Lohmann
Lars Bertram
Lars Bertram, MD
Platform Head
Phone number:+49 451 8792 9521

Current Position:

(1) Professor & Head Platform of the "Lübeck Interdisciplinary Platform for Genome Analytics" (LIGA), Institutes of Neurogenetics & Integrative and Experimental Genomics; University of Lübeck, Germany

(2) Reader in Neurogenetics, School of Public Health, Faculty of Medicine, Imperial College London, UK

Research Focus:

Genomics of complex diseases; neurodegeneration; aging; micro-RNA function and dysfunction; computational genomics

Education & Scientific training

2014 - present              Professor of Genome Analytics, Institute for Neurogenetics, University of Lübeck, Germany

2013 - present              Reader in Neurogenetics, School of Public Health, Imperial College London, UK

2008 - 2014                  Head of Research Group, Max-Planck Institute for Molecular Genetics, Berlin, Germany

2004 - 2008                  Assistant Professor of Neurology, Harvard Medical School, Boston, MA

2002 - 2008                  Assistant in Genetics, Dept of Neurology, Massachusetts General Hospital, Boston, MA

2001 - 2004                  Instructor in Neurology, Dept of Neurology, Massachusetts General Hospital, Boston, MA

1999 - 2001                  Postdoctoral Fellow, Dept of Neurology, Massachusetts General Hospital, Boston, MA

1997 - 1999                  Resident, Clinic for Psychiatry and Psychotherapy, Technical University, Munich, Germany

Awards & Memberships


2015                               Visiting Professor Scholarship, Chinese Academy of Sciences 

2010                               Special-Award of the Hans-und-Ilse-Breuer Foundation for Research in Alzheimer's Disease 

2009                               Independent Investigator Award, National Alliance for Research on Schizophrenia and Depression

2004                               Young Investigator Award, National Alliance for Research on Schizophrenia and Depression

2001                               Fellowship of the Harvard Center for Neurodegeneration and Repair, Harvard Medical School

1999                               Postdoctoral Research Fellowship of German Research Foundation (DFG)

1996                               Stipend of the ERASMUS foundation by The European Commission

1994                               Stipend of the Collège Franco-Allemand, Strasbourg, France


Editorial boards:

2015-present                Movement Disorders

2012-present                Human Mutation

2009-present                Int J Mol Epi Genet

2009-present                Eur J Clin Investigation

2007-present                Neurogenetics



American Society of Human Genetics

European Society of Human Genetics

Reviewer Activities

Journals (selection):                       

American Journal of Human Genetics, American Journal of Medical Genetics, Annals of Neurology, Archives of Neurology, Brain Research, European Journal of Human Genetics, Human Molecular Genetics, Molecular Psychiatry, Nature Genetics, Nature Neuroscience, Neurobiology of Aging, Neurobiology of Disease, Neurochemical Research, Neurology, New England Journal of Medicine, Pharmacogenomics, PNAS, Trends in Genetics

Grant Agencies (selection):                

Alzheimer’s Association (Chicago, IL, USA), Deutsche Forschungsgemeinschaft (DFG), European Research Council (ERC), Health Research Board (Dublin, Ireland), Michael J. Fox Foundation for Parkinson’s Research (New York, NY, USA), National Institutes of Health (Bethesda, MD, USA), Stichting voor Alzheimer Oderzoek (Antwerp, Belgium), Wellcome Trust (London, UK)

Research Funding

Funding summary (for projects as PI or WP-PI, since 1999):

Number:          1 NIH grant, 1 EU grant, 1 DFG grant, 3 BMBF grants, 14 foundation grants USA, 1 foundation grant Germany

Total amount:  Approx. EUR4.5 million 



All publications: 132

Citations: >6700 (as of April 1st, 2015, source: ISI Web of Knowledge)

Cumulative impact factors: 1081.5

H-index: 34

For regular updates please visit ResearcherID.

Original articles (in chronological order):

  1. Pallapies D, Muhs A, Bertram L, Rohleder G, Nagyivanyi P, Peskar BA (1996) “Effects of single oral doses of lysine clonixinate and acetylsalicylic acid on platelet functions in man.” Eur J Clin Pharm 49 (5): 351-4. [IF: 1.771]
  2. Bertram L, Busch R, Spiegl M, Lautenschlager NT, Müller U, Kurz A (1998) “Paternal age is a risk factor for Alzheimer disease in the absence of a major gene.” Neurogenetics 1: 277-280. [IF: 2.094]
  3. Bertram L, Blacker D, Crystal A, Mullin K, Keeney D, Jones J, Basu S, Yhu S, Guenette S, McInnis M, Go R, Tanzi R. (2000) “Candidate genes showing no evidence for association or linkage with Alzheimer’s disease using family-based methodologies.” Exp Gerontol 35(9-10): 1353-61. [IF: 2.622]
  4. Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE (2000) ”Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.” Science 290(5500):2302-3. [IF: 23.872]
  5. Guenette SY, Bertram L, Crystal A, Bakondi B, Hyman BT, Rebeck GW, Tanzi RE, Blacker D (2000) “Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer’s patients.” Neurosci Lett 296(1): 17-20. [IF: 2.091]
  6. Bertram L, Guenette S, Jones J, Keeney D, Mullin K, Crystal A, Basu S, Yhu S, Deng A Rebeck GW, Hyman BT, Go R, McInnis M, Blacker D, Tanzi R. (2001) “No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease.” Ann Neurol 49(1): 114-6. [IF: 8.481]
  7. Bertram L, Hayward B, Lake S, Falls K, Van Eerdewegh P, Blacker D. (2001) “Family-based tests of association in the presence of known linkage.” Genetic Epidemiology; 21(Suppl 1):S292-S297. [IF: 1.822]
  8. Blacker D, Bertram L, Saunders J, Moscarillo TJ, Albert M, Wiener H, Perry RT, Collins JS, Harrell LE, Go RCP, Mahoney A, Beaty T, Fallin MD, Avramopoulos D, Chase GA, Folstein MF, McInnis MG, Bassett SS, Doheny KJ, Pugh EW, Tanzi RE (2003) “Results of a high-resolution genome screen of 437 Alzheimer's disease families.” Hum Mol Genet 12: 23-32. [IF: 8.597]
  9. McQueen MB, Bertram L, Rimm EB, Blacker D, Santangelo SL (2003): A QTL “A QTL genome scan of the metabolic syndrome and its component traits.” Genetic Analysis Workshop 13, Almasy L et al, eds; BMC Genetics 4 (Suppl 1): S96. [IF: 0.924]
  10. Bertram L, Saunders AJ, Mullin K, Sampson A, Moscarillo TJ, Basset SS, Go RCP, Blacker D, Tanzi RE (2003). “No association between marker D10S1423 and Alzheimer's disease.” Mol Psychiatry 8: 571-3. [IF: 5.539]
  11. Saunders AJ*, Bertram L*, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D (2003). Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet 12: 2765-76. *shared first authors [IF: 8.597]
  12. Bertram L, Menon R, Mullin K, Parkinson M , Bradley M, Blacker D, Tanzi RE (2004). “PEN2 is not a genetic risk factor for Alzheimer’s disease in a large family sample”. Neurology 62(2):304-306. [IF: 5.973]
  13. Bertram L, Parkinson M, Mullin K, Menon R, Blacker D, Tanzi RE (2004). “No association between a previously reported OLR1 3’UTR polymorphism and Alzheimer’s disease in a large family sample.” J Med Genetics 41(4): 286-288. [IF: 4.112]
  14. Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ (2004). “Partial loss-of-function mutations in insuling-degrading enzyme that induce diabetes also impair degradation of amyloid β-protein.” Am J Path 164(4):1425-34. [IF: 6.441]
  15. Bertram L, Hiltunen M, Parkinson J, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Moscarillo T, Hyman B, Wagner S, Becker K, Blacker D, Tanzi RE (2005) “Family-based association between Alzheimer’s disease and variants in UBQLN1N Engl J Med 352(9):884-94. [IF: 44.016]
  16. Bertram L, Hsiao M, Mullin K, Parkinson M, Menon R, Moscarillo T, Blacker D, Tanzi RE (2005). “ACAT1 is not associated with Alzheimer’s disease in two independent family-based samples” Mol Psychiatry 10(6):522-4. [IF: 9.335]
  17. Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, Bertram L, Mullin K, Tanzi RE, Blacker D, Albert MS, Sperling RA (2005) “Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD” Neurology 9;65(3):404-11. [IF: 5.056]
  18. Bertram L, Parkinson M, McQueen MB, Mullin K, Hsiao M, Menon R, Moscarillo TJ, Blacker D, Tanzi R (2005) “Further evidence for LBP-1c/CP2/LSF association in Alzheimer’s disease families” J Med Genet 42(11):857-62. [IF: 4.330]
  19. Jiang H, Harrington D, Raby B, Bertram L, Blacker D, Weiss ST, Lange C (2006). “A family-based association test for time-to-onset data with time-dependent differences between the hazard functions” Genet Epi 30(2):124-32. [IF: 5.226]
  20. Bertram L, Hsiao M, Lange C, Blacker D, Tanzi RE (2006) “SNP rs498055 on chromosome 10q24 is not associated with Alzheimer’s disease in two independent family samples” Am J Hum Genet 79(1):180-3. [IF: 12.629]
  21. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE (2006) “Ubiquilin 1 modulates amyloid precursor protein trafficking and Ab secretion” J Biol Chem 281(43):32240. [IF: 5.808]
  22. Perry RT, Wiener H, Harrell LE, Blacker D, Tanzi RE, Bertram L, Bassett SS, Go RC (2006) “Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH AD Genetics Initiative cohort.” Am J Med Genet (B) 144(2):220-7. [IF: 4.463]
  23. Bertram L, Hsiao M, McQueen MB, Parkinson M, Mullin K, Blacker D, Tanzi RE (2007) " The LDLR Locus in Alzheimer's disease: A Family-based Study and Meta-Analysis of Case-Control Data" Neurobiol Aging 28(1):18.e1-4. [IF: 5.607]
  24. Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE (2007) “Systematic Meta-Analyses of Alzheimer’s Disease Genetic Association Studies: The AlzGene Database.” Nat Genet 39(1):17-23. [IF: 25.556]
  25. Bertram L, Mullin K, Parkinson M, Hsiao M, Moscarillo TJ, Wagner SL, Becker KD, Velicelebi G, Blacker D, Tanzi RE (2007) “Is alpha-T catenin (VR22) an Alzheimer’s disease risk gene?” J Med Genet 44(1):e63. [IF: 5.535]
  26. Kim J, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE (2007) “Decreased catalytic activity of the insulin degrading enzyme in chromosome 10-linked Alzheimer’s disease families.” J Biol Chem 282(11):7825-32. [IF: 5.581]
  27. Vepsalainen S, Parkinson M, Helisalmi S, Mannermaa A, Soininen H, Tanzi R, Bertram L, Hiltunen M (2007) “Insulin degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population.” J Med Genet 44(9):606-8. [IF: 5.535]
  28. McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D. (2007) “Exploring Candidate Gene Associations with Neuropsychological Performance.” Am J Med Genet (B) Neuropsychiatr Genet 144(8):987-91. [IF: 4.224]
  29. Hamshere ML, Holmans PA, Avramopoulos D, Bassett SS, Blacker D, Bertram L, Wiener H, Rochberg N, Tanzi RE, Myers A, Wavrant-De Vrièze F, Go R, Fallin D, Lovestone S, Hardy J, Goate A, O’Donovan M, Williams J, Owen MJ. (2007) “Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer’s Disease” Hum Mol Genet 16(22):2703-12. [IF: 7.806]
  30. Schaffer BAJ, Bertram L, Miller BL, Mullin K, Weintraub S, Johnson N, Bigio EH, Mesulam M, Wiedau-Pazos M, Jackson G, Cummings JL, Cantor RM, Levey AI, Tanzi RE, Geschwind DH (2008) “Association of GSK3B with Alzheimer's disease and frontotemporal dementia.” Arch Neurol 65(10):1368-74. [IF: 5.874]
  31. Allen NC, Bagade S, McQueen MB, Ioannidis JPA, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L (2008) "Systematic Meta-Analyses and Field Synopsis of Genetic Association Studies in Schizophrenia: The SzGene Database" Nat Genet 40(7):827-34. [IF: 30.259]
  32. Kavvoura FK, McQueen M, Khoury MJ, Tanzi RE, Bertram L, Ioannidis JPA (2008) “Evaluation of the potential excess of statistically significant findings in reported genetic association studies: application to Alzheimer's disease” Am J Epi 168(8):855-65. [IF: 5.454]
  33. Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE (2008) "Effects of ubiquilin 1 on the unfolded protein response" J Mol Neurosci 38(1):19-30. [IF: 2.061]
  34. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BMM, Hooli B, DiVito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliot K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE (2008) “Genome-wide association analysis reveals novel Alzheimer’s disease susceptibility loci in addition to APOE” Am J Hum Genet 83(5):623-32. [IF: 10.153]
  35. Bertram L, Schjeide BMM, Holi B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE (2008) “No Association between CALHM1 and Alzheimer’s Disease Risk” Cell 135(6):993-4. [IF: 31.253]
  36. Schjeide BMM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Lange C, Blacker D, Tanzi RE, Bertram L (2009) “Assessment of Alzheimer’s disease case-control associations using family-based methods” Neurogenetics 10(1):19-25. [IF: 3.486]
  37. Schjeide BMM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L  (2009) “Follow-up of genome-wide association results suggests GAB2 as an Alzheimer's disease susceptibility gene” Arch Neurol 66(2):250-4. [IF: 6.312]
  38. Fardo DW, Becker KD, Bertram L, Tanzi RE, Lange C (2009) "Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium" Eur J Hum Genet 17(12):1676-82. [IF: 3.564]
  39. Won S, Bertram L, Becker D, Tanzi RE, Lange C (2009) "Maximizing the power of genome-wide association studies: a novel class of powerful family-based association tests" Stat Biosci 1:125-143. [IF: n.a.]
  40. Pihlajamäki M, O'Keefe K, Bertram L, Tanzi RE, Dickerson BC, Blacker D, Albert MS, Sperling RA (2009) "Evidence of altered posteromedial cortical fMRI activity in subjects at risk for Alzheimer disease" Alzheimer Dis Assoc Disord 24(1):28-36. [IF: 2.875]
  41. Castaldi PJ, Cho MH, Cohn M, Langerman F, Moran S, Tarragona N, Moukhachen H, Venugopal R, Hasimja D, Kao E, Wallace B, Hersh CP, Bagade S, Bertram L, Silverman EK, Trikalinos TA (2010) "The COPD genetic association compendium: a comprehensive online database of COPD genetic associations" Hum Mol Genet 19(3):526-34. [IF: 8.058]
  42. Giedraitis V, Glaser A, Sarajaervi T, Brundi RM, Gunnarsson MD, Schjeide BMM, Tanzi RE, Helisalmi S, Pirttilae T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M (2010) "CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid" Neurosci Lett 469(2):265-7. [IF: 2.055]
  43. Dolan SM, Hollegaard MV, Merialdi M, Betran AP, Allen T, Abelow C, Nace J, Lin BK, Khoury MJ, Ioannidis JPA, Bagade S, Zheng X, Dubin RA, Bertram L, Velez DR, Menon R (2010) "Synopsis of preterm birth genetic association studies:  the preterm birth genetics knowledge base (PTBGene)" Public Health Genomics [DOI: 10.1159/000294202]. [IF: 3.049]
  44. Laumet G, Chouraki V, Boley BG, Legry V, Heath S, Zelenika D, Fievet N, Hannequin D, Delepine M, Pasquier F, Hanon O, Brice A, Epelbaum J, Berr C, Dartigues JF, Tzourio C, Campion D, Lathrop M, Bertram L, Amouyel P, Lambert JC (2010) " Systematic analysis of candidate genes for Alzheimer’s disease in a French, genome-wide association study." J Alzheimers Dis 20(4):1181-8. [IF: 4.261]
  45. Saykin AJ, Shen L, Foroud TM, Potkin SG, Swaminathan S, Kim S, Risacher SL, Nho K, Huentelman MJ, Craig DW, Thompson PM, Stein JL, Moore JH, Farrer LA, Green RC, Bertram L, Jack CR Jr, Weiner MW; Alzheimer's Disease Neuroimaging Initiative (2010) "Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans." Alzheimers Dement 6(3):265-73. [IF: 5.902]
  46. Lebedeva E, Stingl JC, Thal DR, Ghebremedhin E, Strauss J, Ozer E, Bertram L, Einem BV, Tumani H, Otto M, Riepe MW, Högel J, Ludolph AC, Arnim CA (2010) "Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD" Neurobiol Aging 33(1):201.e9–18. [IF: 6.634]
  47. Lambert JC, Sleegers K, González A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, Haines JL, Tognoni G, Fiévet N, Dartigues JF, Tzourio C, Engelborghs S, Arosio B, Coto E, De Deyn P, Del Zompo M, Mateo I, Boada M, Antunez C, Lopez-Arrieta J, Epelbaum J, Schjeide BM, Frank-Garcia A, Giedraitis V, Helisalmi S, Porcellini E, Pilotto A, Forti P, Ferri R, Delepine M, Zelenika D, Lathrop M, Scarpini E, Siciliano G, Solfrizzi V, Sorbi S, Spalletta G, Ravaglia G, Valdivieso F, Vepsäläinen S, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Hanon O, Piccardi P, Annoni G, Mann D, Marambaud P, Seripa D, Galimberti D, Tanzi RE, Bertram L, Lendon C, Lannfelt L, Licastro F, Campion D, Pericak-Vance MA, Soininen H, Van Broeckhoven C, Alpérovitch A, Ruiz A, Kamboh MI, Amouyel P (2010) "The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study" J Alzheimers Dis Aug 30 [Epub ahead of print; PMID: 20847397]. [IF: 4.261]
  48. Timmermann B, Kerick M, Roehr C, Fischer A, Barmeyer C, Seemann P, Koenig J, Lappe M, Kuss AW, Garshasbi M, Bertram L, Trappe K, Werber M, Herrmann B, Zatloukal K, Lehrach H, Schweiger MR (2010) "Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis" PLoS ONE 22;5(12):e15661. [IF: 4.411]
  49. Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen K, Lu A, Maynard CJ, Romano D, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M (2011) "Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation" Traffic 12(3):330-48. [IF: 5.278]
  50. Schjeide BMM, Schnack C, Lambert JC, Lill CM, Kirchheiner J, Tumani H, Otto M, Tanzi RE, Lehrach H, Amouyel P, von Arnim C, Bertram L (2011) "The role of CLU, CR1, and PICALM on Alzheimer's disease risk and CSF biomarker levels" Arch Gen Psychiat 68(2):207-13.          [IF: 12.016]
  51. Pfeiffer T, Bertram L, Ioannidis JP (2011) "Quantifying selective reporting and the Proteus phenomenon for multiple datasets with similar bias" PLoS One 29;6(3):e18362. [IF: 4.092]
  52. Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M (2011) "Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking" Mol Cell Biol 31(11):2326-40. [IF: 5.527]
  53. Chatzinasiou F, Lill CM, Kypreou K, Stefanaki I, Nicolaou V, Spyrou G, Evangelou E, Roehr JT, Kodela E, Katsambas A, Tsao H, Ioannidis JP, Bertram L, Stratigos AJ (2011) "Comprehensive Field Synopsis and Systematic Meta-analyses of Genetic Association Studies in Cutaneous Melanoma" J Natl Cancer Inst 103(16):1227-35. [IF: 13.757]
  54. Lill CM, Abel O, Bertram L, Al-Chalabi A (2011) "Keeping up with genetic discoveries in amyotrophic lateral sclerosis: The ALSoD and ALSGene databases" Amyotroph Lateral Scler 12(4):238-49. [IF: 3.091]
  55. Haapasalo A, Viswanathan J, Kurkinen KM, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M (2011) "Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation" Commun Integr Biol 4(4):428-32. [IF: n.a.]
  56. Lill CM, Schjeide BM, Akkad DA, Blaschke P, Winkelmann A, Gerdes LA, Hoffjan S, Luessi F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Bertram L*, Zipp F* (2012) "Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample" Neurogenetics 13(1):83-6. [IF: 3.354]
  57. Won S, Lu Q, Bertram L, Tanzi RE, Lange C (2012) "On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies." Hum Hered 73(1):35-46. [IF: 1.569]
  58. Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L (2012) "Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database." PLoS Genet 2012 Mar;8(3):e1002548. [IF: 8.517]
  59. Wallace BC, Small K, Brodley CE, Lau J, Schmid CH, Bertram L, Lill CM, Cohen JT, Trikalinos TA (2012) "Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining" Genet Med Apr 5. doi: 10.1038/gim.2012.7. [IF: 5.560]
  60. Hooli BV, Mohapatra G, Mattheisen M, Parrado AR, Roehr JT, Shen Y, Gusella JF, Moir R, Saunders AJ, Lange C, Tanzi RE, Bertram L (2012) " Role of common and rare APP DNA sequence variants in Alzheimer disease" Neurology 78(16):1250-7. [IF: 8.249]
  61. Lill CM, Liu T, Schjeide BM, Roehr JT, Akkad DA, Damotte V, Alcina A, Ortiz MA, Arroyo R, Lopez de Lapuente A, Blaschke P, Winkelmann A, Gerdes LA, Luessi F, Fernadez O, Izquierdo G, Antigüedad A, Hoffjan S, Cournu-Rebeix I, Gromöller S, Faber H, Liebsch M, Meissner E, Chanvillard C, Touze E, Pico F, Corcia P; ANZgene Consortium, Dörner T, Steinhagen-Thiessen E, Baeckman L, Heekeren HR, Li SC, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Fontaine B, Vandenbroeck K, Matesanz F, Urcelay E, Bertram L*, Zipp F* (2012) "Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects." J Med Genet 49, 558–562. [IF: 5.703]
  62. Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Bertram L, Bozi M, Barcikowska M, Crosiers D, Clarke CE, Facheris MF, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon BS, Jamrozik Z, Krygowska-Wajs A, Lesage S, Lill CM, Lin JJ, Lynch T, Lichtner P, Lang AE, Libioulle C, Murata M, Mok V, Jasinska-Myga B, Mellick GD, Morrison KE, Meitnger T, Zimprich A, Opala G, Pramstaller PP, Pichler I, Park SS, Quattrone A, Rogaeva E, Ross OA, Stefanis L, Stockton JD, Satake W, Silburn PA, Strom TM, Theuns J, Tan EK, Toda T, Tomiyama H, Uitti RJ, Van Broeckhoven C, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Yomono HS, Yueh KC, Zhao Y, Gasser T, Maraganore D, Krüger R (2012) "A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants" J Med Genet 49(11):721-726. [IF: 5.703]
  63. Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Van Broeckhoven C, Bertram L, Bozi M, Crosiers D, Clarke C, Facheris M, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon B, Lesage S, Lill CM, Lin JJ, Lynch T, Lichtner P, Lang AE, Mok V, Jasinska-Myga B, Mellick GD, Morrison KE, Opala G, Pramstaller PP, Pichler I, Park SS, Quattrone A, Rogaeva E, Ross OA, Stefanis L, Stockton JD, Satake W, Silburn PA, Theuns J, Tan EK, Toda T, Tomiyama H, Uitti RJ, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Yueh KC, Zhao Y, Gasser T, Maraganore D, Krüger R; GEO-PD Consortium. (2012) "Large-scale replication and heterogeneity in Parkinson disease genetic loci." Neurology 79, 659–667. [IF: 8.249]
  64. González-Pérez P, Lu Y, Chian RJ, Sapp PC, Tanzi RE, Bertram L, McKenna-Yasek D, Gao FB, Brown RH Jr. (2012). "Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS." Neurobiol Dis 48, 391–398. [IF: 5.624]
  65. Li SC, Papenberg G, Nagel IE, Preuschhof C, Schröder J, Nietfeld W, Bertram L, Heekeren HR, Lindenberger U, Bäckman L (2013) "Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory." Neurobiol Aging 34(1), 358.e1–10. [IF: 6.166]
  66. Lill CM, Schjeide BM, Graetz C, Liu T, Damotte V, Akkad DA, Blaschke P, Gerdes LA, Kroner A, Luessi F, Cournu-Rebeix I, Hoffjan S, Winkelmann A, Touze E, Pico F, Corcia P, Otaegui D, Antigüedad A, Alcina A, Comabella M, Montalban X, Olascoaga J, Matesanz F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Rieckmann P, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Fontaine B, Zipp F, Vandenbroeck K, Bertram L (2013). Genome-wide significant association of ANKDRD55 rs6859219 and multiple sclerosis risk. J Med Genet 50(3):140-3. [IF: 5.703]
  67. Papenberg G, Bäckman L, Nagel IE, Nietfeld W, Schröder J, Bertram L, Heekeren HR, Lindenberger U, Li SC (2013) " Dopaminergic Gene Polymorphisms Affect Long-term Forgetting in Old Age: Further Support for the Magnification Hypothesis." J Cogn Neurosci 25(4):571-9.  [IF: 4.493]
  68. Broer L, Lill CM, Schuur M, Amin N, Roehr JT, Bertram L, Ioannidis JP, van Duijn CM (2013) "Distinguishing true from false positives in genomic studies: p values." Eur J Epidemiol 28(2):131-8. [IF: 5.118]
  69. Bertram L, Böckenhoff A, Demuth I, Düzel S, Eckhardt R, Li SC, Lindenberger U, Pawelec G, Siedler T, Wagner GW, Steinhagen-Thiessen E (2013) " Cohort profile: The Berlin Aging Study II (BASE-II)" Int J Epidemiol [Epub ahead of print; Mar 14.]. [IF: 6.982]
  70. Li SC, Passow S, Nietfeld W, Schröder J, Bertram L, Heekeren HR, Lindenberger U "Dopamine modulates attentional control of auditory perception: DARPP-32 (PPP1R1B) genotype effects on behavior and cortical evoked potentials" Neuropsychologia 51(8):1649-61. [IF: 3.477]
  71. Viswanathan J, Haapasalo A, Kurkinen KM, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M (2013) "Ubiquilin-1 Modulates γ-Secretase-Mediated ε-Site Cleavage in Neuronal Cells" Biochemistry 52(22):3899-912. [IF: 3.377]
  72. Schuck NW, Doeller CF, Schjeide BM, Schröder J, Frensch PA, Bertram L, Li SC (2013) "Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task" Hippocampus (doi: 10.1002/hipo.22148). [IF: 5.492]
  73. Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández O, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L*, Zipp F* (2013; *shared authorship) "MANBA, CXCR5, SOX8, RPS6KB1, and ZBTB46 are genetic risk loci for multiple sclerosis" Brain 36(Pt 6):1778-82. [IF: 9.915]
  74. Pichler I, Del Greco F, Gögele M, Lill CM, Bertram L, Do CB, Eriksson N, Foroud T, Myers RH, PD GWAS Consortium, Nalls M, Keller MF, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, Benyamin B, Whitfield JB, Genetics of Iron Status Consortium, Pramstaller PP, Hicks AA, Thompson JR, Minelli C (2013) "Serum iron levels and the risk of Parkinson’s disease: a Mendelian randomization study" PLoS Medicine 10(6):e1001462 [IF: 15.253]
  75. Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE (2013) "Rare autosomal copy number variations in early-onset familial Alzheimer's disease" Mol Psychiatry ([doi: 10.1038/mp.2013.77). [IF: 14.897]
  76. Papenberg G, Bäckman L, Nagel IE, Nietfeld W, Schröder J, Bertram L, Heekeren HR, Lindenberger U, Li SC (2013) "COMT Polymorphism and Memory Dedifferentiation in Old Age" Psychol Aging 2013 Jul 8. [Epub ahead of print]. [IF: 3.089]
  77. Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M (2013) "Elucidation of the BACE1 Regulating Factor GGA3 in Alzheimer's Disease" J Alzheimers Dis 1;37(1):217-32. [IF: 4.174]
  78. Shen L, Thompson PM, Potkin SG, Bertram L, Farrer LA, Foroud TM, Green RC, Hu X, Huentelman MJ, Kim S, Kauwe JSK, Li Q, Liu E, Moore JH, Munsie L, Nho K, Ramanan VK, Stone DJ, Swaminathan S, Toga AW, Weiner MW, Saykin AJ (for the Alzheimer’s Disease Neuroimaging Initiative) (2013) "Genetic Analysis of Quantitative Phenotypes in AD and MCI: Imaging, Cognition and Biomarkers" Brain Imaging Behav [Epub ahead of print]. [IF: 2.667]
  79. Schuck NW, Frensch PA, Schjeide BM, Schröder J, Bertram L, Li SC (2013) "Effects of aging and dopamine genotypes on the emergence of explicit memory during sequence learning" Neuropsychologia 51(13):2757-69. [IF: 3.477]
  80. Ghisletta P, Bäckmann L, Bertram L, Brandmaier AM, Gerstorf D, Liu T, Lindenberger U "The Val/Met Polymorphism of the Brain-Derived Neurotrophic Factor (BDNF) Gene Predicts Decline in Perceptual Speed in Older Adults" Psychology and Aging 29(2):384-92. [IF: 3.089]
  81. Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser F, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E, Eck S, Aherrahrou Z, Narstaedt J, Willenborg C, Bruse P, Braenne I, Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C, Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U,CARDIoGRAM, Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenbert C, Schunkert H (2013) "Dysfunctional nitric oxide signalling increases risk of myocardial infarction" Nature 504(7480):432-6. [IF: 38.597]
  82. Papenberg G, Li SC, Nagel IE, Nietfeld W, Schjeide BM, Schröder J, Bertram L, Heekeren HR, Lindenberger U, Bäckman L (2014) "Dopamine and glutamate receptor genes interactively influence episodic memory in old age" Neurobiol Aging 35(5):1. [IF: 6.166]
  83. Lill CM, Schilling M, Ansaloni S, Schröder J, Jaedicke M, Luessi F, Schjeide BMM, Mashychev AV, Graetz C, Akkad DA, Gerdes LA, Kroner A, Blaschke P, Hoffjan S, Winkelmann A, Dörner T, Rieckmann P, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zett UK, Epplen JT, Zipp F, Bertram L (2014) "Assessmen of miRNA-related SNP effects in the 3’ untranslated region of the IL22RA2 risk locus in multiple sclerosis” Neurogenetics 15(2):129-34. [IF: 2.658]
  84. Liu, T,  Li SC, Papenberg G, Schröder J,  Roehr JT,  Nietfeld W, Lindenberger U,  Bertram L (2014) “No Association between CTNNBL1 and Episodic Memory Performance” Transl Psychiatry 4:e454. [IF:4.360 ]
  85. Hooli BV, Parrado AR, Mullin K, Yip WK, Liu T, Roehr JT, Qiao D, Jessen F, Peters O, Becker T, Ramirez A, Lange C, Bertram L, Tanzi RE (2014) "The rare TREM2 R47H variant exerts only a modest effect on Alzheimer’s disease risk" Neurology 83(15):1353-8. [IF: 8.303 ]
  86. Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R [...] Bertram L, Eriksson N, Foroud T, Singleton AB (2014) "Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease." Nat Genet 46(9):989-93. [IF: 29.648]
  87. Schröder J, Ansaloni S, Schilling M, Liu T, Radke J, Jaedicke M, Schjeide BM, Mashychev A, Tegeler C, Radbruch H, Papenberg G, Düzel S, Demuth I, Bucholtz N, Lindenberger U, Li SC, Steinhagen-Thiessen E, Lill CM, Bertram L (2014) "MicroRNA-138 is a potential regulator of memory performance in humans." Front Hum Neurosci 11;8:501. [IF: 2.895]
  88. Athanasiadis EI, Antonopoulou K, Chatzinasiou F, Lill CM, Bourdakou MM, Sakellariou A, Kypreou K, Stefanaki I, Evangelou E, Ioannidis JP, Bertram L, Stratigos AJ, Spyrou GM (2014) "A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools" Database (Oxford) 7;pii: bau101. [IF: 4.457]
  89. Antonopoulou K, Stefanaki I, Lill CM, Chatzinasiou F, Kypreou KP, Karagianni F, Athanasiadis E, Spyrou GM, Ioannidis JP, Bertram L, Evangelou E, Stratigos AJ (2014) "Updated Field Synopsis and Systematic Meta-Analyses of Genetic Association Studies in Cutaneous Melanoma: The MelGene Database" J Invest Dermatol doi: 10.1038/jid.2014.491. [IF: 6.372]
  90. Ahmed I, Lee PC, Lill CM, Searles Nielsen S, Artaud F, Gallagher LG, Loriot MA, Mulot C, Nacfer M, Liu T, Biernacka JM, Armasu S, Anderson K, Farin FM, Lassen CF, Hansen J, Olsen JH, Bertram L, Maraganore DM, Checkoway H, Ritz B, Elbaz A (2014) "Lack of replication of the GRIN2A-by-coffee interaction in Parkinson disease" PLoS Genet 10(11):e1004788. [IF: 8.167]
  91. Nalls MA, Bras J, Hernandez DG, Keller MF, Majounie E, Renton AE, Saad M, Jansen I, Guerreiro R, Lubbe S, Plagnol V, Gibbs JR, Schulte C, Pankratz N, Sutherland M, Bertram L, Lill CM, DeStefano AL, Faroud T, Eriksson N, Tung JY, Edsall C, Nichols N, Brooks J, Arepalli S, Pliner H, Letson C, Heutink P, Martinez M, Gasser T, Traynor BJ, Wood N, Hardy J, Singleton AB (2015) "NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases" Neurobiol Aging 36(3):1605.e7-1605.e12. [IF: 4.853]
  92. Bellander M, Bäckman L, Liu T, Schjeide BM, Bertram L, Schmiedek F, Lindenberger U, Lövdén M (2015) "Lower baseline performance but greater plasticity of working memory for carriers of the val allele of the COMT Val158Met polymorphism." Neuropsychology 29(2):247-54. [IF: 3.425]
  93. Wilcox R, Brænne I, Brüggemann N, Winkler S, Wiegers K, Bertram L, Anderson T, Lohmann K (2015) "Genome sequencing identifies a novel mutation in ATP1A3 in a family with dystonia in females only" J Neurol 262(1):187-93. [IF: 3.841]
  94. Domingo A, Westenberger A, Lee LV, Brænne I, Liu T, Vater I, Rosales R, Jamora RD, Pasco PM, Cutiongco-Dela Paz EM, Freimann K, Schmidt TG, Dressler D, Kaiser FJ, Bertram L, Erdmann J, Lohmann K, Klein C (2015) "New insights into the genetics of X-linked dystonia-parkinsonism (XDP, DYT3)" Eur J Hum Genet (in press). [IF: 4.225]
  95. Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, van der Lee SJ, Le Hellard S, Liu T, Marioni RE, Oldmeadow C, Postmus I, Smith AV, Smith JA, Thalamuthu A, Thomson R, Vitart V, Wang J, Yu L, Zgaga L, Zhao W, Boxall R, Harris SE, Hill WD, Liewald DC, Luciano M, Adams H, Ames D, Amin N, Amouyel P, Assareh AA, Au R, Becker JT, Beiser A, Berr C, Bertram L (...) Launer L, Fitzpatrick AL, Seshadri S, Mosley TH Jr, Deary IJ (2015) "Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)" Mol Psychiatry 20(2):183-92. [IF: 15.147]
  96. Lill CM, Rengmark A, Pihlstrøm L, Fogh I, […], Al-Chalabi A, Toft M, Ritz B, Bertram L. The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease. Alzheimers Dement (in press) [IF: 17.472]
  97. Holi BV, Lill CM, Mullin K, Qiao D, Lange C, Bertram L, Tanzi RE (2015) "PLD3 gene variants ; and Alzheimer’s disease" Nature 520(7545):E7-8. doi: 10.1038/nature14040. [IF: 42.351]
  98. Lill CM, Hansen J, Olsen JH, Binder H, Ritz B, Bertram L. " Impact of Parkinson’s disease risk loci on age at onset" Mov Disord (in press).  [IF: 5.634]

Review articles:

  1. Bertram L, Tanzi RE (2001) “Of replications and refutations: The status of Alzheimer’s disease genetics research.” Curr Neurol Neursci Rep 1: 442-452. [IF: 2.455 {IF von 2008}]
  2. Bertram L, Tanzi RE (2001) “Dancing in the dark? The Status of Late-Onset Alzheimer’s Disease Genetics”. J Mol Neurosci 17:127-136. [IF: 1.688]
  3. Tanzi RE, Bertram L (2001) “New frontiers in Alzheimer’s disease genetics.” Neuron 32:181-184. [IF: 14.153]
  4. Bertram L, Tanzi RE (2004)“Alzheimer’s Disease: One Disorder, Too Many Genes?” Hum Mol Genetics 13(S1): R135-141. [IF: 7.801]
  5. Bertram L, Tanzi RE (2004) “The Current Status of Alzheimer’s Disease Genetics: “What Can We Tell Our Patients?” Pharm Res 50(4):385-96. [IF: 1.498]
  6. Tanzi RE, Bertram L (2005) “Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.” Cell 120(4):545-55. [IF: 29.431]
  7. Bertram L, Tanzi RE (2005) “The Genetic Epidemiology of Neurodegenerative Disease.” J Clin Invest 115(6):1449-57. [IF: 15.053]
  8. Bertram L (2008) “The Genetics of Schizophrenia: Current Status and Future Perspectives” Schiz Bull 34(5):806-12. [IF: 6.592]
  9. Tanzi RE, Bertram L (2008) “News & Views: Alzheimer’s disease – The latest suspect” Nature 454(7205): 706-708. [IF: 31.434]
  10. Bertram L, Tanzi RE (2008) “Thirty Years of Alzheimer’s Disease Genetics: Implications from Systematic Meta-analyses” Nat Rev Neurosci 9(10):768-78. [IF: 25.94]
  11. Khoury MJ, Bertram L, Boffetta P, Butterworth AS, Chanock SJ, Dolan SM, Fortier I, Garcia-Colsas M, Gwinn M, Higgins JPT, Janssens CJW, Ostell J, Owen RP, Pagon RA, Rebbeck TR, Rothman N, Bernstein JL, Burton PR, Campbell H, Chockalingam A, Furberg H, Little J, O’Brien TR, Seminara D, Vineis P, Winn DM, Yu W, Ioannidis JPA (2009) “Genome Wide Association Studies, Field Synopses and the Development of the Knowledge Base on Genetic Variation and Human Diseases” Am J Epi 170(3):269-79. [IF: 5.589]
  12. Bertram L (2009) "Alzheimer's disease genetics: current status and future perspectives" Int Rev Neurobiol 84:167-84. [IF: 4.017]
  13. Bertram L, Tanzi RE (2009) "Genome-wide association studies in Alzheimer's disease" Hum Mol Genet 18(R2):R137-45. [IF: 7.386]
  14. Haapasalo A, Viswanathan J, Bertram L, Soininen H, Tanzi RE, Hiltunen M (2010) "Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation" Biochem Soc Trans 38(Pt 1):150-5 [IF: 3.989]
  15. Sleegers K, Lambert JC, Bertram L, Cruts M, Amouyel P, Van Broeckhoven C (2010) "The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects" Trends Genet 26(2):84-93. [IF: 11.364]
  16. Bertram L, Tanzi RE (2010) "New light on an old CLU" Nat Rev Neurol 6(1):11-3. [IF: 6.511]
  17. Lill CM, Bertram L (2010) "Online databases and systematic meta-analyses of genetically complex diseases" Med Genetik [DOI 10.1007/s11825-010-0225-0] [IF: 0.071]
  18. Bertram L, Heekeren H (2010) "Obesity and the brain: a possible genetic link" Alzheimer’s Research & Therapy 2(5):27. [IF: n.a.]
  19. Bertram L, Lill CM, Tanzi RE (2010) "The genetics of Alzheimer's disease: Back to the future" Neuron 68(2):270-81. [IF: 14.027]
  20. Bertram L (2011) "Alzheimer's genetics in the GWAS era: a continuing story of 'replications and refutations" Curr Neurol Neurosci Rep 11(3):246-53. [IF: 3.455]
  21. Haworth A, Bertram L, Carrera P, Elson JL, Braastad CD, Cox DW, Cruts M, den Dunnen JT, Farrer MJ, Fink JK, Hamed SA, Houlden H, Johnson DR, Nuytemans K, Palau F, Rayan DL, Robinson PN, Salas A, Schüle B, Sweeney MG, Woods MO, Amigo J, Cotton RG, Sobrido MJ (2011) "Call for participation in the neurogenetics consortium within the Human Variome Project" Neurogenetics [Epub ahead of print]. [IF: 3.354]
  22. Hiltunen M, Bertram L, Saunders AJ (2011) "Genetic risk factors: their function and comorbidities in Alzheimer's disease" Int J Alzheimers Dis Epub 2011 Aug 11. [IF: n.a.]
  23. Bertram L, Hampel H (2011) "The role of genetics for biomarker development in neurodegeneration" Prog Neurobiol 95(4):501-4. [IF: 8.874]
  24. Hampel H, Prvulovic D, Teipel S, Jessen F, Luckhaus C, Frölich L, Riepe MW, Dodel R, Leyhe T, Bertram L, Hoffmann W, Faltraco F; German Task Force on Alzheimer's Disease (GTF-AD) (2011) "The future of Alzheimer's disease: the next 10 years" Prog Neurobiol 95(4):718-28. [IF: 8.874]
  25. Lill CM, Bertram L (2011) "Towards unveiling the genetics of neurodegenerative diseases." Semin Neurol 31(5):531-41. [IF: 1.642]
  26. Bertram L, Tanzi RE (2012) "The genetics of Alzheimer's disease." Prog Mol Biol Transl Sci 107:79-100 [IF: n.a.]
  27. Lill CM, Bertram L (2012) "Developing the "next generation" of genetic association databases for complex diseases" Hum Mutat Jul 2. doi: 10.1002/humu.22149 [IF: 5.213]
  28. Elias-Sonnenschein L, Bertram L, Visser PJ (2012) "Relation between genetic risk factors and markers for Alzheimer pathology" Biomarkers in Medicine 6, 477–495. [IF: 3.217]
  29. Sobrido MJ, Cacheiro P, Carracedo A., and Bertram L (2012) "Databases for neurogenetics: introduction, overview, and challenges" Hum. Mutat 33, 1311–1314. [IF: 5.213]
  30. Hampel H, Lista S, Teipel SJ, Garaci F, Nisticò R, Blennow K, Zetterberg H, Bertram L, Duyckaerts C, Bakardjian H, Drzezga A, Colliot O, Epelbaum S, Broich K, Lehéricy S, Brice A, Khachaturian ZS, Aisen PS, Dubois B (2014) "Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020" Biochem Pharmacol 15;88(4):426-49  [IF: 4.576]

Editorials & Commentaries:

  1. Lill CM, Schjeide BMM, Roehr JT, Zauft U, Allen NC, Zipp F, McQueen MB, Kavvoura F, Ioannidis JPA, Khoury MJ, Tanzi RE, Bertram L (2010) "Response to 'Critical Reappraisal of a COMT Transversion Variant in Schizophrenia'" Biol Psych 67(7):e45-8. [IF: 8.674]
  2. Bertram L, Parrado AR, Tanzi RE (2013) "TREM2 and neurodegenerative disease." New Engl J Med 369(16):1565. [IF: 51.658]
  3. Lill CM, Bertram L (2015) "Probing the epigenome by EWAS: a new era in brain disease research" Mov Disord 30(2):197. [IF: 5.634]
  4. Bertram L, Klein C (2015) "Probing the Exome in Alzheimer Disease and Other Neurodegenerative Disorder" JAMA Neurol 72(4):389-91. [IF: 11.910]

Book chapters: 

  1. Riemenschneider M, Bertram L (2000) “Apparative Diagnostik.“ In: Demenzen in Theorie und Praxis (Springer, Heidelberg).
  2. Bertram L, Blacker D, Crystal A, Jones J, Keeney D, MacKenzie-Ingano, Mullin K, Basu S, Yhu S, McInnis M, Go RCP, Saunders AJ, Tanzi RE (2001) “Candidate Genes Showing No Evidence of Association with AD: Results of the NIMH-AD Genetics Initiative.” In: Alzheimer’s Disease: Advances in Etiology, Pathogenesis and Therapeutics Editors: K Iqbal, S. Sisodia, B Winblad; John Wiley & Sons.
  3. Bertram L & Tanzi RE (2003). Genetics of Alzheimer’s disease. In: Neurodegeneration :The Molecular Pathology of Dementia and Movement Disorders; Editor: DW Dickson; ISN Neuropath Press, Basel.
  4. BertramL, BlackerD, MullinK, ParkinsonM, SampsonA, MoscarilloT, SaundersAJ, Tanzi RE (2003) “A High-Resolution Alzheimer’s Disease Genome Screen: Evidence For Genetic Linkage On Twelve Chromosomes” In: Alzheimer’s Disease and Related Disorders: Research Advances; Editors: K Iqbal, B Winblad; Ana Aslan International Academy of Aging.
  5. Bertram L, Tanzi RE (2005) “Genetics of Alzheimer’s Disease”; In: Neurodegenerative Diseases – Neurobiology, Pathogenesis, and Therapeutics; Editors: Beal MF, Lang AE, Ludolph A; Cambridge University Press; pp. 441-451
  6. Bertram L, Tanzi RE (2006) “Genetics of Neurodegenerative Diseases”; In: Basic Neurochemistry, 7th Edition; Editors: Siegel GJ, Albers RW, Brady S, Price D; Elsevier Publishing; pp. 653-666.
  7. Bertram L (2006) “The Genetics of Alzheimer’s Disease”; In: Alzheimer’s Disease: Advances in Genetics, Molecular and Cellular Biology; Editors: Sisodia S, Tanzi RE; Springer Press
  8. Bertram L (2008) "Genetics of Alzheimer's Disease"; In: Handbook of Clinical Neurology (Vol. 89; 3rd Series);Editors: Aminoff M, Boller F, Swaab D; Elsevier Publishing; pp. 223-32
  9. Bertram L (2010) “Field Synopsis of Genetic Association Studies in Schizophrenia”; In: Human Genome Epidemiology (Second Edition); Editors: Khoury MJ, Gwinn M, Bradley L, Little J, Higgins J, Ioannidis JPA; Oxford Press
  10. Bertram L & Tanzi RE (2011). "Chapter 9: Genetics of Alzheimer’s disease" In: Neurodegeneration :The Molecular Pathology of Dementia and Movement Disorders, 2nd edition; Editors: Dickson DW, Weller RO; Wiley-Blackwell
  11. Bertram L (2011) "Vol.3, Chapter 5: The Genetics of Alzheimer's Diseases" In: Dementia; Editor: P McNamara; ABC/CLIO Press, Santa Barbara, CA.
  12. Lill CM, Tanzi RE, Bertram L (2012) “Chapter 41: Genetics of Neurodegenerative Diseases”; In: Basic Neurochemistry, 8th Edition; Editors: Siegel GJ, Albers RW, Brady S, Price D; Elsevier Publishing; pp. 719-736.
  13. Bertram L (2013) "Chapter 85: Genetics of Alzheimer's Disease"; In: Genomic and Personalized Medicine, 2nd edition; Editors: Ginsburg & Willard; Elsevier Publishing
  14. Bertram L (2015) "Next generation sequencing in Alzheimer's Disease: Current status and challenges"; In: Methods in Molecular Biology Systems Biology of Alzheimer’s Disease: Methods and Protocols; Editors: Castrillo JI & Oliver SG; Springer

Miscellaneous publications:

1.   Bertram, L. (2010), "Thirty years of Azheimer's genetics: what's new and what's next?", in Hardy, J. (ed.), Alzheimer's Disease: , The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (

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