Melissa Vos
Melissa Vos, PhD
Research group leader
Phone number:+49 451 3101 8203

Current Position:

Group leader ‘Drosophila Models of Movement Disorders’

Research Focus:

Studying the underlying mechanisms that are causative for Parkinson disease in a fly model.
Education & Scientific training

Education:

2015/2016 EMBO long term fellowship; Institute of Neurogenetics, University of Lübeck, Germany, Advisor: Christine Klein

08/2014 – current Postdoctoral researcher; Institute of Neurogenetics, University Lübeck, Germany, Advisor: Christine Klein

11/2012 – 07/2014 Postdoctoral researcher; KU Leuven, Center for Human Genetics, VIB Center for the Biology of Disease, Leuven, Belgium, Advisor: Patrik Verstreken

01/2009 – 10/2012 Ph.D. in Biomedical sciences; KU Leuven, Center for Human Genetics, VIB Center for the Biology of Disease, Leuven, Belgium, Advisor: Patrik Verstreken

10/2003 – 07/2007 Biomedical sciences (Masters in Biomedical Science); KU Leuven, Belgium graduated with Distinction, Advisor: Dr. Marc Van Ranst (Characterization of novel Papillomaviruses)

Other Advanced Training:

05/2011 Summer School on Advanced Light Microscopy; VIB Research Training Group (VRTC), Ghent, Belgium

11/2010 Writing a Biomedical paper; Catholic University Leuven, Leuven, Belgium

09/2009 Next generation sequencing data analysis; Maastricht University, Maastricht, Netherlands

Supervision undergraduate students

Supervision undergraduate students:

2014-2015 Master student : Luigi Montibeller

2013-2014 Master student : Liesbeth Deaulmerie

2013 Rotation student Biomedical sciences : Liesbeth Deaulmerie

2009-2010 Master student: Evelien Peeters

Awards & Fellowships

Awards and fellowships:

2015 Postdoctoral felloyship; EMBO

09/2014 Special acknowledgement baron Simonart foundation to encourage research in clinical pharmacology, Belgium

09/2014 Prize of the Research Council Award (7500€) to stimulare young postdoctoral researchers, KU Leuven, Belgium

09/12/2013 Travel grant; FWO, mitochondrial Keystone meeting, Santa Fe, USA

17/10/2013 Travel grant (400€); GEO-PD meeting, Lubeck, Germany

10/2013-2016 Post-doctoral fellowship; FWO, Belgium

2013 Runner-up in the Larry Sandler award for best dissertation in the Drosophila field, GSA                                       

2013 Post-Doctoral Fellowship; KU Leuven                                                                                                        

01/06/2012 Author of the month; Award from the Center for Human genetics KU Leuven                                     

2009-2012 Predoctoral Fellowship; IWT Vlaanderen, Belgium; Fellowship obtained after personal defense of the project

Publications

1. Vos M, Lovisa B, Geens A, Morais VA, Wagnières G, Van den Bergh H, Gingen A, De Strooper B, Tardy Y, Verstreken P. (2013) Near-infrared light at 808 nm boosts Complex IV-dependent respiration and rescues a Parkinson-related pink1 model, Plos One 8 e78562

2. Haddad D, Vilain S, Vos M, Esposito G, Matta S, Kalscheuer VM, Craessaerts K, Leyssen M, Nascimento RMP, Vianna-Morgante AM, De Strooper B, Van Esch H, Morais VA, Verstreken P. (2013) Mutations in the Intellectual Disability Gene Ube2a Cause Neuronal Dysfunction and Impair Parkin-Dependent Mitophagy, Mol Cell 50(6):831-43

3. Esposito G, Vos M, Vilain S, Van Meensel S, Schaap O, Verstreken P. (2013) Aconitase causes iron toxicity in Drosophila pink1 mutants, Plos Genet 9 e1003478

4. van Bon BW, Oortveld MA, Nijtmans LG, Fenckova M, Nijhof B, Besseling J, Vos M, Kramer JM, de Leeuw N, Castells-Nobau A, Asztalos L, Viragh E, Ruiter M, Hofmann F, Eshuis L, Collavin L, Huyen MA, Asztalos Z, Verstreken P, Rodenburg RJ, Smeitink JA, de Vries BB, Schenck A. (2013) CEP89 is required for mitochondrial metabolism and neuronal function in man and fly, Hum Mol Genet 22(15):3138-51

5. Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, Van Meensel S, Schaap O, De Strooper B, Meganathan R, Morais VA, Verstreken P. (2012) Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency, Science 336:1306-10

6. Vilain S, Esposito G, Haddad D, Schaap O, Dobreva MP, Vos M, Van Meensel S, Morais VA, De Strooper B, Verstreken P. (2012) The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants, PLos Genet 8 e1002456

7. Vos M*, Lauwers E* and Verstreken P. (2010) Synaptic mitochondria and organization of vesicle pools in health and disease. Front Syn Neurosci: Synaptic Vesicle Pool Organization, eds. R. Renden and M. Hodge . 2, art. 139.  *equal contribution

8. Rector A, Stevens H, Lacave G, Lemey P, Mostmans S, Salbany A, Vos M, Van Doorslaer K, Ghim SJ, Rehtanz M, Bossart GD, Jenson AB, Van Ranst M. (2008) Genomic characterization of novel dolphin papillomaviruses provides indications for recombination within the Papillomaviridae, Virology 378 (1): 151-61 [IF: 3,37] [citations: 22]

Attended meetings

Attended meetings:

14-16/06/2014 Ophtalmology Conference; OMICS, Baltimore, USA, Contribution: Invited speaker, Vitamin K2 as a potential novel therapeutic strategy in Parkinson’s disease

18-23/02/2014 Mitochondrial dynamics and physiology; Keystone Symposia, Santa Fe, USA, Contribution: Oral presentation, Stimulation of the electron transport chain as therapy in Parkinson’s disease

17-19/10/2013 GEO-PD meeting; Lubeck, Germany, Contribution: Invited speaker, Vitamin K2 is a mitochondrial electron carrier that rescues Pink1 deficiency

03-07/04/2013 54th annual Drosophila Research Conference; Genetics Society of America Conferences, Washington, USA, Contribution: Poster, 'Does stimulation of ETC rescue Pink1 deficiency'

06-10/03/2013 International Conference On Alzheimer’s & Parkinson’s diseases; Kenes, Florence, Italy, Contribution: Poster, Vitamin K2 is a mitochondrial electron carrier that rescues Pink1 Deficiency

19-23/03/2012 Mitochondrial dynamics and function/ cell death pathways: beyond apoptosis; Keystone Symposia, Banff, Canada, Contribution: Oral Presentation, Vitamin K2 is a mitochondrial electron carrier that rescues Pink1 deficiency

20/11/2011 Lind seminar; Leuven, Belgium, Contribution: Oral Presentation, Vitamin K2 is a mitochondrial electron carrier that rescues Pink1 deficiency

03-07/10/2011 Neurobiology of Drosophila; Cold Spring Harbor, USA, Contribution: Poster, Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency

16-18/06/2010 Mitochondrial medicine; Scottsdale, Arizona, USA, Contribution: Poster, A Parkinson disease modifier screen identifies dominant suppressors that rescue pink1 associated mitochondrial defects

04/06/2010 Dutch/Belgian Drosophila Research Conference; Leiden, Netherlands, Contribution: Poster, 'A Parkinson disease modifier screen identifies dominant suppressors that rescue pink1 associated mitochondrial defects'

02/09/2009 Science Club Technologies; VIB, Leuven, Belgium, Contribution: Invited speaker, Identifying modifiers of the Parkinson related gene pink1

22-27/03/2009 Mitochondrial medicine; Keystone Symposia, Whistler, Canada, Contribution: Poster, Identifying modifiers of the parkinson related gene pink1

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