Philip Seibler
Philip Seibler, PhD
Research section leader
Phone number:+49 451 3101 8208

Current Position:

Professor & Section Head ‘Applied Stem Cell Biology’

Research focus:

Induced pluripotent stem cells to generate neuronal disease models

Education & Scientific training

Education:

10/2001 – 10/2006 Studies of Molecular Life Sciences, University of Lübeck, Germany

03/2006 – 10/2006 Master thesis; University of Lübeck, Section of Clinical and Molecular Neurogenetics (Prof. Christine Klein) “Genetische Untersuchung bei Bewegungsstörungen: Feinkartierung zur Lokalisation genetischer Ursachen bei spinocerebellärer Ataxie bzw. Restless-legs-Syndrom sowie Mutationsanalyse bei Patienten mit Morbus Parkinson“
Master of Science

11/2006 – 10/2011 Doctoral thesis; University of Lübeck, Section of Neurogenetics (Prof. Christine Klein) “Molecular studies of two genetic movement disorders: PRKRA-linked dystonia and PINK1-linked Parkinson disease”
PhD (Dr. rer. nat.)

11/2011 – 03/2016 Group leader; University of Lübeck, Institute of Neurogenetics (Prof. Christine Klein)

04/2017 – present Professor for Applied Stem Cell Biology; University of Lübeck, Institute of Neurogenetics (Prof. Christine Klein)

Scientific training:

03/2006 – present Institute of Neurogenetics (University of Lübeck), supervised by Prof. Klein
Molecular studies of movement disorders

01/2009 – 09/2010 MassGeneral Institute for Neurodegenerative Disease (Massachusetts General Hospital and Harvard Medical School, Boston, MA; USA), supervised by Prof. Dimitri Krainc
Impact of PINK1 mutations in neurons derived from induced pluripotent stem cells


04/2016 – 03/2017 Centre for Applied Neurogenetics (University of British Columbia, BC, Vancouver, Canada), supervised by Prof. Matt Farrer
Dopamine metabolism and electric activity in iPS-derived neurons

 

Awards & Memberships

Awards:

2009 International Research Fellowship of the German Academic Exchange Service, Harvard Medical School, USA

2011 Young Investigator Award of the German Society of Neurogenetics

2012 Participant of the German-wide business game competition EXIST-priME-Cup for business start-ups: Campus-Cup (1st placed team), Master-Cup (1st placed team) and Professional-Cup (7th placed team). EXIST is a support program of the Federal Ministry of Economics and Technology (BMWi).

2016 International Research Fellowship of the German Research Foundation, University of British Columbia, Canada

Memberships:

Society for Neuroscience (SfN)

German Society for Neurogenetics (DGNG)

Publications

Selection of 5 most important publications out of 18;
cumulative impact factor: 137; mean 7.2

  1. Seibler P, Graziotto J, Jeong H, Simunovic F, Klein C, Krainc D. Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells. J Neurosci 2011;31:5970-5976.

  2. Morais VA, Haddad D, Craessaerts K, De Bock P-J, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B. PINK1 loss of function mutations affect Complex I activity via NdufA10 ubiquinone uncoupling. Science 2014;344:203-207.

  3. Vulinovic F, Lohmann K, Rakovic A, Capetian P, Alvarez-Fischer D, Schmidt A, Weißbach A, Erogullari A, Kaiser FJ, Wiegers K, Ferbert A, Rolfs A, Klein C, Seibler P. Unraveling cellular phenotypes of novel TorsinA/TOR1A mutations. Hum Mutat 2014;35:1114-22 (selected as monthly highlight).

  4. Munsie LN*, Milnerwood AJ*, Seibler P* (*contributed equally), Beccano-Kelly DA, Tatarnikov I, Khinda J, Volta M, Kadgien C, Cao LP, Tapia L, Klein C, Farrer MJ. Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's Disease VPS35 mutation p.D620N. Hum Mol Genet 2015;24(6):1691-703.

  5. Zanon A, Kalvakuri S, Rakovic A, Foco L, Guida M, Schwienbacher C, Serafin A, Rudolph F, Trilck M, Grünewald A, Stanslowsky N, Wegner F, Giorgio V, Lavdas AA, Bodmer R, Pramstaller PP, Klein C, Hicks AA, Pichler I*, Seibler P* (*contributed equally). SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Hum Mol Genet 2017. doi: 10.1093/hmg/ddx132. [Epub ahead of print]
Complete list of publications
  1. Moro E, Volkmann J, König IR, Winkler S, Hiller A, Hassin-Baer S, Herzog J, Schnitzler A, Lohmann K, Pinsker MO, Voges J, Djarmatic A, Seibler P, Lozano AM, Rogaeva E, Lang AE, Deuschl G, Klein C. Bilateral subthalamic stimulation in Parkin and PINK1 parkinsonism. Neurology 2008;70:1186-1191.

  2. Seibler P, Djarmati A, Langpap B, Hagenah J, Schmidt A, Brüggemann N, Siebner H, Jabusch HC, Altenmüller E, Münchau A, Lohmann K, Klein C. A heterozygous frameshift mutation in PRKRA (DYT16) associated with generalised dystonia in a German patient. Lancet Neurol 2008;7:380-381.

  3. Rakovic A, Grünewald A, Seibler P, Ramirez A, Kock N, Orolicki S, Lohmann K, Klein C. Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Hum Mol Genet 2010;19:3124-3137.

  4. Seibler P, Graziotto J, Jeong H, Simunovic F, Klein C, Krainc D. Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells. J Neurosci 2011;31:5970-5976.

  5. Grünewald A, Arns B, Seibler P, Rakovic A, Münchau A, Ramirez A, Sue CM, Klein C. ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome. Neurobiol Aging 2012;33:1843.e1-7.

  6. Arif B, Kumar KR, Seibler P, Franke F, Fatima A, Winkler S, Nürnberg G, Thiele H, Nürnberg P, Jamil AZ, Brüggemann A, Ali A, Abbas G, Klein C, Naz S, Lohmann K. Exome sequencing reveals a novel OPA3 mutation: An example of reverse phenotyping. Arch Neurol 2012;33:1843.e1-7

  7. Rakovic A, Shurkewitsch K, Seibler P, Grünewald A, Zanon A, Hagenah J, Krainc D, Klein C. Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons. J Biol Chem 2013;288:2223-2237.

  8. Trilck M, Hübner R, Seibler P, Klein C, Rolfs A, Frech MJ. Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks. Orphanet J Rare Dis 2013;8:144.

  9. Doss S, Lohmann K, Seibler P, Arns B, Klopstock T, Zühlke C, Freimann K, Winkler S, Lohnau T, Drungowski M, Nürnberg P, Wiegers K, Lohmann E, Naz S, Kasten M, Bohner G, Ramirez A, Endres M, Klein C. Recessive dystonia-ataxia syndrome in a Turkish family caused by a COX20 (FAM36A) mutation. J Neurol 2014;261(1):207-12.

  10. Morais VA, Haddad D, Craessaerts K, De Bock P-J, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B. PINK1 loss of function mutations affect Complex I activity via NdufA10 ubiquinone uncoupling. Science 2014;344:203-207.

  11. Vulinovic F, Lohmann K, Rakovic A, Capetian P, Alvarez-Fischer D, Schmidt A, Weißbach A, Erogullari A, Kaiser FJ, Wiegers K, Ferbert A, Rolfs A, Klein C, Seibler P. Unraveling cellular phenotypes of novel TorsinA/TOR1A mutations. Hum Mutat 2014;35:1114-22 (selected as monthly highlight).

  12. Erogullari A, Hollstein R, Seibler P, Braunholz D, Koschmidder E, Depping R, Eckhold J, Lohnau T, Gillessen-Kaesbach G, Grünewald A, Rakovic A, Lohmann K, Kaiser FJ. THAP1, the gene mutated in DYT6 dystonia, autoregulates its own expression. Biochim Biophys Acta. 2014;1839:1196-204.

  13. Munsie LN*, Milnerwood AJ*, Seibler P* (*contributed equally), Beccano-Kelly DA, Tatarnikov I, Khinda J, Volta M, Kadgien C, Cao LP, Tapia L, Klein C, Farrer MJ. Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's Disease VPS35 mutation p.D620N. Hum Mol Genet 2015;24(6):1691-703.

  14. Rakovic A, Seibler P, Klein C. iPS models of Parkin and PINK1. Biochem Soc Trans. 2015;43:302-7.

  15. Capetian P, Azmitia L, Pauly MG, Krajka V, Stengel F, Bernhardi EM, Klett M, Meier B, Seibler P, Stanslowsky N, Moser A, Knopp A, Gillessen-Kaesbach G, Nikkhah G, Wegner F, Döbrössy M, Klein C. Plasmid-Based Generation of Induced Neural Stem Cells from Adult Human Fibroblasts. Front Cell Neurosci 2016;10:245.

  16. Vos M, Geens A, Böhm C, Deaulmerie L, Swerts J, Rossi M, Craessaerts K, Leites EP, Seibler P, Rakovic A, Lohnau T, De Strooper B, Fendt SM, Morais VA, Klein C, Verstreken P.Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency. J Cell Biol 2017;216:695-708.

  17. Grütz K, Seibler P, Weissbach A, Lohmann K, Carlisle FA, Blake DJ, Westenberger A, Klein C, Grünewald A. Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia. Sci Rep 2017;7:41156.

  18. Zanon A, Kalvakuri S, Rakovic A, Foco L, Guida M, Schwienbacher C, Serafin A, Rudolph F, Trilck M, Grünewald A, Stanslowsky N, Wegner F, Giorgio V, Lavdas AA, Bodmer R, Pramstaller PP, Klein C, Hicks AA, Pichler I*, Seibler P* (*contributed equally). SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila. Hum Mol Genet 2017. doi: 10.1093/hmg/ddx132. [Epub ahead of print]

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