Aleksandar Rakovic
Aleksandar Rakovic, PhD
Research group leader
Phone number:+49 451 3101 8203

Current Position:

Postdoctoral fellow at the Institute of Neurogenetics, University of Lübeck

Research focus:

Cell biology and proteomics of human neurodegenerative diseases, mainly Parkinson disease 

Curriculum vitae

Education:

10/1995 – 05/2005 Studies of Biology at the University of Belgrade, Serbia.

05/2005 – 02/2006 Diploma thesis; University of Belgrade andInstitute of Nuclear Sciences, Belgrade, in the Laboratory for Radiobiology and Molecular Genetics (Dr. D. Alavantic)

Master of Science (Dipl. Molecular Biology and Physiology)

02/2006 – 11/2007 Doctoral thesis; University of Belgrade and Institute of Nuclear Sciences, Belgrade, in the Laboratory for Radiobiology and Molecular Genetics (Dr. D. Alavantic)

11/2007 – 12/2011 Doctoral thesis; University of Lübeck, Section of Clinical and Molecular Neurogenetics (Prof. C. Klein) at the Department of Neurology (Prof. D. Kömpf)

„Impact of Parkinson disease-related mutations in PINK1 on Parkin and mitochondrial fusion/fission factors in human-derived cells“

PhD (Dr. rer. nat.)

Scientific training:

11/2004 – 05/2005 Laboratory for Radiobiology and Molecular Genetics (Institute of Nuclear Sciences, Belgrade, Serbia), supervised by Dr. D. Alavantic

Detection of polymorphisms in genes related to cardiovascular diseases (LPL, CTLA4, ACE, ApoE, MMP-9, IL-6, MCP-1)

02/2007 – 11/2007 Section of Clinical and Molecular Neurogenetics (University of Lübeck), supervised by Prof. Dr. C. Klein

Molecular genetics and functional studies of various movement disorders (Dystonia, Parkinson disease)

Awards:

2007 Scholarship from the University of Lübeck, Lübeck, Germany

2007 Scholarship from the German Academic Exchange Service (DAAD)

2011 Travel grant from the Movement Disorder Society

Memberships:

Movement disorders society (MDS)

National genome research net (NGFN)

Publications

Selection of 5 most important publications out of 11;
cumulative impact factor: 68.6; mean 6.2

  1. Rakovic A, Stiller B, Djarmati A, Flaquer A, Freudenberg J, Toliat M.R, Linnebank M, Kostic V, Lohmann K, Paus S, Nürnberg P, Kubisch C, Klein C, Wüllner U, Ramirez A. Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease. Mov Disord 2009;24:429-433.

  2. Rakovic A, Grunewald A, Seibler P, Ramirez A, Kock N, Orolicki S, Lohmann K, Klein C. Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Hum Mol Genet 2010;19:3124-3137.

  3. Kaiser FJ, Osmanovic A, Rakovic A, Erogullari A, Uflacker N, Braunholz D, Lohnau T, Orolicki S, Albrecht M, Gillessen-Kaesbach G, Klein C, Lohmann K. The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6). Ann Neurol 2010;68:554-559.

  4. Rakovic A, Grunewald A, Kottwitz J, Bruggemann N, Pramstaller P. P, Lohmann K, Klein C. Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One 2011; 6: e16746.

  5. Rakovic A, Grünewald A, Voges L, Hofmann S, Orolicki S, Lohmann K, Klein C. PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1. Parkinsons Dis 2011;2011:153979.

Complete list of publications
  1. Zivković M, Raković A, Stanković A. Allele-specific detection of C-1562T polymorphism in the matrix metalloproteinase-9 gene: genotyping by MADGE. Clin Biochem 2006;39:630-632.

  2. Brüggemann N, Kock N, Lohmann K, König IR, Rakovic A, Hagenah J, Schmidt A, Ziegler A, Jabusch HC, Siebner H, Altenmüller E, Münchau A, Klein C. The D216H variant in the DYT1 gene: a susceptibility factor for dystonia in familial cases? Neurology 2009;72:1441-1443.

  3. Djarmati A, Schneider SA, Lohmann K, Winkler S, Pawlack H, Hagenah J, Brüggemann N, Zittel S, Fuchs T, Raković A, Schmidt A, Jabusch HC, Wilcox R, Kostić VS, Siebner H, Altenmüller E, Münchau A, Ozelius LJ, Klein C. Mutations in THAP1 (DYT6) and generalised dystonia with prominent spasmodic dysphonia: a genetic screening study. Lancet Neurol 2009;8:447-452.

  4. Rakovic A, Stiller B, Djarmati A, Flaquer A, Freudenberg J, Toliat MR, Linnebank M, Kostic V, Lohmann K, Paus S, Nürnberg P, Kubisch C, Klein C, Wüllner U, Ramirez A. Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease. Mov Disord 2009;24:429-433.

  5. Kaiser FJ, Osmanoric A, Rakovic A, Erogullari A, Uflacker N, Braunholz D, Lohnau T, Orolicki S, Albrecht M, Gillessen-Kaesbach G, Klein C, Lohmann K. The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6). Ann Neurol 2010;68:554-559.

  6. Grünewald A, Voges L, Rakovic A, Kasten M, Vandebona H, Hemmelmann C, Lohmann K, Orolicki S, Ramirez A, Schapira AH, Pramstaller PP, Sue CM, Klein C. Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS One 2010;5:e12962.

  7. Weissbach A, Djarmati A, Klein C, Dragasević N, Zühlke C, Raković A, Guzvić M, Butz E, Tönnies H, Siebert R, Petrović I, Svetel M, Kostić VS, Lohmann K. Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15. Mov Disord 2010;25:1577-1582.

  8. Rakovic A, Grünewald A, Seibler P, Ramirez A, Kock N, Orolicki S, Lohmann K, Klein C. Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Hum Mol Genet 2010;19:3124-3137.

  9. Osmanovic A, Dendorfer A, Erogullari A, Uflacker N, Braunholz D, Rakovic A, Vierke G, Gil-Rodríguez C, Münchau A, Albrecht M, Brüggemann N, Gillessen-Kaesbach G, Klein C, Lohmann K, Kaiser FJ. Truncating mutations in THAP1 define the nuclear localization signal. Mov Disord 2011;26:1565-1567.

  10. Rakovic A, Grünewald A, Voges L, Hofmann S, Orolicki S, Lohmann K, Klein C. PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1. Parkinsons Dis 2011;2011:153979.

  11. Rakovic A, Grünewald A, Kottwitz J, Brüggemann N, Pramstaller PP, Lohmann K, Klein C. Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One 2011;6:e1674.

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