Christine Klein
Christine Klein, MD
Institute of Neurogenetics Head
Phone number:+49 451 3101 8200

Personal Information

Name Christine Klein, nee Winter

Date of Birth May 31st, 1969

Place of Birth Hamburg, Germany

Position/Title Institute of Neurogenetics Head, Schilling Professor of Neurology

Address Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck
Ratzeburger Allee 160, 23538 Lübeck, Germany

Phone: +49-451-2903351; Fax: +49-451-2903353
Email: christine.klein@neuro.uni-luebeck.de

Education/Position
1988-1994: Medical School (Hamburg, Heidelberg, Lübeck)
including elective periods abroad:
  • University of Vitebsk, Belarus (Neurology, 1991)
  • Karolinska Hospital, Stockholm, Sweden (Pediatrics, 1992)
  • University of Rennes, France (Neurology, 1993)
  • Wollongong District Hospital, Wollongong, Australia (Accident & Emergency, 1993)

1991-1992: Medical Thesis (Laboratory of Craig Garner, PhD, Center of Molecular Neurobiology, Hamburg; “Characterization of synaptic proteins of the rat brain”)

1994-1995: Final year studies (Neurology, Queen Square, London, UK; Internal Medicine, University of Oxford, Oxford, UK)

1995-1997: Medical residency at the Dept. of Neurology, Medical University of Lübeck, Germany

1997-1999: Neurogenetics Research Fellow (Laboratory of Xandra O. Breakefield, PhD), Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA

1999-2001: Resident, Dept. of Neurology, Medical University of Lübeck, Germany

2001: Habilitation (Neurogenetics; “Molecular genetics of dystonia”

2001-2005: Assistant Professor in Neurogenetics

2004–2012: Research Fellow/Clinical Fellow/Sabbatical (1 – 5 months each) with Anthony E. Lang, MD at the Movement Disorders Unit of the Toronto Western Hospital, Toronto, Canada

2005–2009: Lichtenberg Professor of Clinical and Molecular Neurogenetics

2009–present: Schilling Professor of Clinical and Molecular Neurogenetics and Section Head
 
2013-present: Head of the Institute of Neurogenetics (University of Lübeck)
Licensure and certification

1995: National Board of Medical Examiners Licensing Examination

1996: Schleswig-Holstein (S-H) College of Physicians General License

2004: Neurology (S-H College of Physicians)

2005: College of Physicians and Surgeons of Ontario (Clinical Fellow)

Honors
1997-1999: International Research Fellowship awarded by the German Research Foundation (DFG)

2000: Hilde Ulrich's Foundation for Research in Parkinson's Disease Award 2000

2000: Oppenheim Award of the German Dystonia Foundation

2001: Parkinson Award of the German Neurological Society

2003: Heisenberg Fellowship of the German Research Foundation (DFG)

2005: Lichtenberg Career Development Award of the Volkswagen Foundation

2007: Heinrich Pette Award of the German Neurological Society

2008: Honorary member of the Belgian Neurological Society

2008: Derek-Denny Brown Award of the American Neurological Association

2009: Schilling Career Development Award of the Hermann and Lilly Schilling Foundation

2011: Julius Brendel Visitiing Professor at the University of Auckland, New Zealand

2012: Offer: Chair of the Division of Neurology, University of Ottawa, Ottawa, Canada
 
2012: Mount Sinai Medical School of Medicine Grand Rounds Dedicated to Melvin Yahr, New York, USA
 
2014: BioMedTec Award
 
2015: The 19th John and Rose Druker Memorial Lecture, Longwood Grand Rounds, Boston, USA
Professional Memberships
1997–present: German Neurological Society

1997–present: American Academy of Neurology

1998–present: Movement Disorders Society

2000–present: German Society of Neurogenetics

2003–2007: Editorial Board of Movement Disorders

2006–2009: Member of the Scientific Advisory Board of the Dystonia Medical Research Foundation

2008–present: Editorial Board of Neurology

2008–present: American Neurological Association

2007–present: Member of the Congress Scientific Planning Committee of the Movement Disorder Society

2009–present: Councilor to the Neurogenetics Section of the American Academy of Neurology

2010–present: Editorial Board of Movement Disorders

2010–present: Member of the Scientific Advisory Board of the Bachmann-Strauss Dystonia & Parkinson Foundation

2010–present: Head of the Neurogenetics Committee of the German Neurological Society
Research supports and grants

Stipends and Scholarships

1989–1995 Stipend from The German National Merit Foundation (grants scholarships to 0.25% of German students)

1997–1999 International Research Scholarship from the German Research Foundation

2003–2005 Heisenberg Scholarship from the German Research Foundation

2005–2009 Lichtenberg Career Development Award from the Volkswagen Foundation (Tenure track, W2, Associate Professor)

2009–2018 Career Development Award from the Hermann and Lilly Schilling Foundation (Tenure track, W3, Full Professor)

Grants

“Molecular biology of early-onset Parkinson’s disease“

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 1999-2002
Amount: 150,000 €

“Molecular genetics of dystonia“

Principal Investigator: Christine Klein, MD
Funding Agency: German Dystonia Foundation
Funding period: 1999-2001
Amount: 8,500 €

“Competence Network Parkinson’s Disease“

Principal Investigator: Christine Klein, MD
Funding Agency: Federal Ministry of Education and Research (BMBF)
Funding period: 2000-2004
Amount: 200,000 €

“Genetics of myoclonus-dystonia“

Principal Investigator: Christine Klein, MD
Funding Agency: Fritz Thyssen Foundation
Funding period: 2000-2003
Amount: 100,000 €

“Frequency of Parkin mutations in Parkinson’s disease“

Principal Investigator: Christine Klein, MD
Funding Agency: Parkinson Disease Foundation (USA)
Funding Period: 2001-2002
Amount: 30,000 €

“Molecular Etiology of early-onset parkinsonism”

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2002-2004
Amount: 250,000 €

“Heisenberg Fellowship“

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2003-2005
Amount: 131,000 €

“Molecular genetic analysis of dopa-responsive dystonia and penetrance studies”

Principal Investigator: Christine Klein, MD
Funding Agency: Edith Fröhnert Foundation
Funding period: 2005-2007
Amount: 45,000 €

“W2 Lichtenberg Professorship (Associate professor)“

Principal Investigator: Christine Klein, MD
Funding Angency: Volkswagen Foundation
Funding period: 2005-2010
Amount: 1,300,000 €

“Infrastructure support of the Lichtenberg Grant“

Principal Investigator: Christine Klein, MD
Funding Angency: Possehl Foundation
Funding period: 2005-2011
Amount: 77,000 €

“Scholarship for Eastern European scientists (DYT8 dystonia)”

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2005-2006
Amount: 16,300 €

“Genetic risk factors of musician´s dystonia as a special subgroup of focal dystonia”

Principal Investigator: Christine Klein, MD
Funding Agency: Dystonia Medical Research Foundation
Funding period: 2006
Amount: 40,000 €

“Impact of mutations in Parkin and PINK1: Endogenous protein function in Parkinson disease”

Principal Investigator: Christine Klein, MD
Funding Agency: Fritz Thyssen Foundation
Funding period: 2006-2008
Amount: 140,000 €

„Identifying the genetic etiology of restless legs syndrome”

Principal Investigators: Katja Lohmann, PhD and Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2007-2009
Amount: 160,000 €

“Genomic biomarkers for Parkinson´s disease”

Principal Investigator: Christine Klein, MD
Funding Agency: European Commission (EU)
Funding period: 2007-2011
Amount: 440,000 €

“Interdisciplinary Center for Genetic Movement Disorders Lübeck”

Principal Investigator: Christine Klein, MD
Funding Agency: Possehl Foundation
Funding period: 2007-2012
Amount: 388,000 €

“Graduate School for Computing in Medicine and Life Sciences” (GSC 235)

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG Program of Excellence)
Funding period: 2007-2012
Amount: 150,000 €

“Family studies of ATP13A2-associated parkinsonism”

Principal Investigator: Christine Klein, MD
Funding agency: Hilde Ulrichs Foundation for Parkinson’s Disease
Funding period: 2008
Amount: 10,000 €

“Support for the 14. Annual Meeting of the German Society of Neurogenetics in Lübeck“

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2008
Amount: 2,630 €

“Role of the PRKRA (DYT16) gene in dystonia”

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2008-2010
Amount: 102,000 €

“Genomics of Recessive Parkinsonism – NGFN‐plus”

Principal Investigator: Christine Klein, MD
Funding agency: Federal Ministry of Education and Research (BMBF)
Funding period: 2008-2013
Amount: 340,000 €

“Schilling Department of Clinical and Molecular Neurogenetics”

Principal Investigator: Christine Klein, MD
Funding agency: Hermann and Lilly Schilling Foundation and Stifterverband für die Deutsche Wissenschaft
Funding period: 2009‐2018
Amount: 4,450,000 €

”Support of a bilateral collaboration with Pakistan”

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2010
Amount: 5,000 €

“Genetic risk factors of musician’s dystonia”;

Principal Investigators: Katja Lohmann, PhD, Christine Klein, MD, and Andreas Ziegler, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2011
Amount: 295,000 €

“Characterization of endophenotypes in focal task-specific dystonia”

Principal Investigator: Christine Klein, MD
Funding Agency: Dystonia Coalition (NINDS)
Funding period: 2011
Amount: 35,500 €

“Elucidation of the genetic cause of DYT4 using exome sequencing”

Principal Investigator: Christine Klein, MD
Funding agency: Bachmann Strauss Dystonia & Parkinson Foundation
Funding period: 2011-2012
Amount: 35,500 €

“Multi‐Site Communication in the Brain” (Collaborative Research Center 936)

Co- Principal Investigators (Subproject C5): Alexander Münchau, MD and Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2011-2014
2015 Amount: 420,000 €

“The role of endogenous PINK1 and Parkin mutations in human dopaminergic neurons”

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: September 2012 to August 2015
Amount: 322,642 €

“Transcranial ultrasonographic evaluation of the basal ganglia in DYT1, DYT11, and DYT12 dystonia”

Principal Investigator: Christine Klein, MD
Funding agency: Bachmann-Strauss Dystonia & Parkinson Foundation
Funding period: 2012 - 2013
Amount: 20,000 USD

“StemBANCC”

Work package leader (W2): Christine Klein, MD
Funding agency: Innovative Medicines Initiative (EU)
Funding period: September 2012 to August 2017
Amount: 794,769 €

“8th Annual Meeting of GEO-PD (Genetic Epidemiology of Parkinson's Disease) in Lübeck”

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2013
Amount: 24,000 €

“Generation of a reference cohort for extreme eating behaviour” SFB134

Principal Investigator: Prof. Dr. Christine Klein
Funding agency: Deutsche Forschungsgemeinschaft (DFG)
Funding period: 2014-2017
Amount: 250,000 €

“Comprehensive Unbiased Risk factor Assessment for Genetics and Environment in Parkinson#s Disease (COURAGE-PD)”

Principal Investigator: Prof. Dr. Christine Klein
Funding agency: Bundesministeriums für Bildung und Forschung (BMBF)
Funding period: 2014-2016
Amount: 157,600 €

“MitoPD Mitochondrial endophenotypes of PD”

Co-Principal Investigator: Prof. Dr. Christine Klein
Funding agency: Bundesministeriums für Bildung und Forschung (BMBF)
Funding period: 2014-2017
Amount: 661.869 €

“Multidisciplinary X-linked Dystonia-Parkinsonism Workshop”

Principal Investigators: Prof. Dr. Christine Klein, Dr. Aloysius Doming, Dr. Ana Westenberger
Funding agency: Fritz Thyssen Foundation
Funding period: May-June 2014
Amount: 9,700 

 


Total external funding since 1999: ~12 million €

Memberships and academic activities

Societies

  • German Society of Neurology
  • German Society of Neurogenetics
  • German Dystonia Society
  • American Neurological Association
  • American Academy of Neurology
  • Movement Disorder Society
  • College of Physicians and Surgeons of Ontario
  • Honorary Member of the Belgian Neurological Society

Research Networks

  • Competence Network Parkinson’s Disease Germany
  • European Restless Legs Syndrome Study Group
  • Neuroprotection and Natural History in Parkinson Plus Syndromes (NNIPPS), GeneticSection
  • Dystonia Study Group USA
  • Parkinson Study Group USA (GenePD Study)
  • Dystonia Coalition (USA)

Boards

  • Co-Chariman of the Ethics Committee of the Competence Network Parkinson’s Disease Germany 
  • Member of the Appointing Committee for the Human Genetics Chair of the University of Lübeck (2004)
  • Member of the Appointing Committee for the Neurology Chair of the University of Lübeck (2009)
  • Member of the Appointing Committee for an Associated Professor of Medical Biometry and Statistics of the University of Lübeck (2009)
  • Member of the Appointing Committee for an Associated Professor of Neuroimaging in Movement Disorders, University of Kiel (2010)
  • Member of the Science Committee of the University of Lübeck (2009)
  • Member of the Steering Committee of the Lübeck Graduate School “Computing in Medicine and Life Sciences” 
  • Member of the Scientific Advisory Board of the Dystonia Medical Research Foundation (2006 – 2009)
  • Dystonia Study Group (since 2006)
  • GenePD Consortium (since 2007)
  • Member of the Scientific Advisory Board of PDGene (MGH/HMS, MJF Foundation und
  • Alzheimer Research Forum; since 2006)
  • Board Member “Gender equality issues at the University of Lübeck” (since 2008)
  • Councilor to the Neurogenetics Section of the American Academy of Neurology and member of the Neurogenetics Topic Work Group
  • Head of the Neurogenetics Working Group of the German Society of Neurology (since 2010) 
  • Member of the Scientific Advisory Board of the Bachmann-Strauss Dystonia & Parkinson Foundation (since 2010)
  • Member of the Senate of the University of Lübeck (since 2011)
  • Member of the “Young Scientist Support Committee” of the University of Lübeck (since 2010)
  • Adviser to the National Government (Ministry of Health) on rare diseases (since 2011)
  • Member of the Appointing Committee for an Associated Professor of neuropsychiatric epidemiology of the University Lübeck (2012)
  • Member of the Appointing Committee for an Associated Professor for genetic susceptibility of lung diseases of the Christian-Albrechts-University Kiel (2012)
  • Member of the Appointing Committee for an Associated Professor of experimental and functional imaging in psychiatry of the University Lübeck (2012)
  • Member of the Appointing Committee for an Associated Professor of psych-neurobiology of the University Lübeck (2013)
  • Member of the Appointing Committee for an Associated Professor of genome-analytics of the University Lübeck (2013)
  • Member of the Appointing Committee for an Associated Professor of International Health of the University Lübeck (2013)
  • Member ofthe Steering Committee of GEO-PD (since 2013)
  • Member of the Appointing Committee for evaluation of the  Associated Professor for signal transduction of cytokine (2014)
  • Member of the Appointing Committee for an temporary Associated Professor for health services research in pediatric oncology of the University Lübeck (2014)
  • Member of the Appointing Committee for an Associated Professor for molecular epileptology in children and youth of the Christian-Albrechts-University Kiel (2014)
  • Member of the Appointing Committee for an Associated Professor of neurology of the Christian-Albrechts-University Kiel (2014)
  • Member of the project management of the Graduate school Lübeck
  • Member of the medical senate of the University Lübeck
  • Member of the Board of the Centre for Clinical Studies , University Lübeck
  • Member of the working group "Human whole genome sequencing" of the Senate Commission on Genetic Research ( Genetic SK ) and the Senate Commission on basic issues in Clinical Research ( SGKF ) of the German Research Society
  • Chair of the Congress Scientific Planning Committee of the International Movement Disorder Society (2015-2017)

Foundations

  • Board of Directors of the Possehl Foundation, Lübeck (grants about 12 million €/per year, including research support, for projects related to the City of Lübeck)
  • Member of the Scientific Advisory Board of the Dystonia Medical Research Foundation (2006-2009)
  • Member of the Scientific Advisory Board of the Bachmann-Strauss Dystonia & Parkinson Foundation (seit 2010)
  • Ad-hoc member of the Lichtenberg Panel of the Volkswagen Foundation (2015)

Symposia and Conferences

  • Organization and Co-Chair of the international symposium “Genetics of Movement Disorders – Gateways and Perspectives”, Lübeck, 2000
  • Organization and Co-Chair of the international symposium “Genetics of Movement Disorders – Gateways and Perspectives II”, Lübeck, 2005
  • Member of the congress planning committee of the 12th Annual Meeting of the German Society of Neurogenetics, Rostock, 2006
  • Member of the congress planning committee of the 5th German Parkinson’s Disease Congress, Ulm, 2007
  • Member of the Congress Scientific Program Committee of the Movement Disorders Society for the annual meetings 2008 (Chicago), 2009 (Paris), 2010 (Buenos Aires), 2011 (Toronto), 2012 (Dublin)
  • Organization and Chair of the 14th Annual Meeting of the German Society of Neurogenetics, Lübeck, 2008
  • Member of the congress planning committee of the 6th German Parkinson’s Disease Congress, Marburg, 2009
  • Member of the congress planning committee of the 7th German Parkinson’s Disease Congress, Kiel, 2011
  • Member of the congress planning committee of the 85th Annual Meeting of the German Society of Neurology, Hamburg, 2012
  • Member of the congress planning committee of the 87th Annual Meeting of the German Society of Neurology, Munich, 2014
  • Chairman of the Congress Scientific Program Committee of the International Parkinson Disease and Movement Disorder Society for the annual conferences 2016 (Berlin) and 2017 (Vancouver)

Editorial Boards

  • Movement Disorders (2003–2007 and 2010-2013)
  • Web Site Editorial Board of the Movement Disorder Society (2008-2010)
  • Neurology (since 2008)
  • Parkinson’s Disease (since 2010)
  • Associate Editor, Movement Disorders (since 2013)
Reviewer Activities

Journals

  • American Journal of Human Genetics 
  • American Journal of Medical Genetics
  • Annals of Neurology
  • Archives of Neurology
  • BBA Molecular Cell Research
  • Brain
  • Cancer Research
  • Clinical Genetics
  • European Journal of Human Genetics
  • European Journal of Neurology
  • FEBS Letters
  • Human Genetics
  • Human Molecular Genetics
  • Human Mutation
  • Journal of Neural Transmission
  • Journal of Neurochemistry
  • Journal of Neurology
  • Journal of Neurology Neurosurgery and Psychiatry
  • Journal of the Neurological Sciences
  • Journal of Nucleic Acids
  • Lancet Neurology
  • Movement Disorders
  • Nature Clinical Practice Neurology
  • Nature Communications
  • Nature Genetics
  • Neurogenetics
  • Neurology
  • Neuropediatrics
  • Neuroscience Letters
  • New England Journal of Medicine
  • PLoS Biology
  • PLoS Genetics
  • Progress in Neurobiology
  • The Journal of Neuroscience
  • The Lancet
  • The Lancet Neurology
  • Trends in Neurosciences

Grants

  • German Research Foundation (DFG)
  • Dystonia Medical Research Foundation
  • European Commission
  • Medical Research Council (MRC) (UK)
  • Prinses Beatrix Fonds (Niederlande)
  • FuL-Programm of the University Lübeck
  • Fortüne-Programm of the University Tübingen
  • Intramurale research funding of the University Kiel
  • Wellcome Trust (London)
  • Elected member of the Neurology Study Section of the German Research Foundation (DFG), 2012-
Awards for members of the Klein team

Katja Lohmann, nee Hedrich, PhD

  • International Research Fellowship” of the Gottlieb Daimler and 
  • Karl Benz Foundation, Harvard University, Boston, USA (2001)
  • Heinrich Dräger Science Award 2004
  • Travel Award of the Erwin Riesch Foundation 2005
  • Graduate Scholarship of the Novartis Foundation for Therapeutic Research 2005
  • Career Development Award of the University of Lübeck (2008-2009)
  • Travel Grant of the Movement Disorders Society for the 13th Annual Congress, Paris, France (2009) 
  • Renate Maaß Award for Brain Research 2011
  • David Marsden Award 2013

Ana Westenberger, nee Djarmati, PhD

  • International Research Fellowship” of the Gottlieb Daimler and 
  • Karl Benz Foundation, University of Lübeck, Lübeck, Germany (2005)
  • Travel Grant of the Movement Disorders Society for the 12th Annual Congress, Chicago, USA (2008) 
  • Career Development Award from the Felgenhauer/German Society of Neurology for a Research Fellowship in Ann Arbor, Michigan, USA (2008)
  • David Marsden Award 2009
  • Career Development Award of the University of Lübeck (2010-2011)
  • Travel Grant of the GlaxoSmithKline Foundation for the Annual Congress of the Movement Disorders Society, Toronto, Canada (2011)

Anne Grünewald, PhD

  • International Research Fellowship of the German Academic Exchange Service, University College London, London, UK (2007)
  • Travel Grant of the Boehringer Ingelheim Fonds for a 6-month research stay at the University of Syndey, Australia (2010)
  • Travel Grant of the German Academic Exchange Service for the Annual Meeting of the American Academy of Neurology, Toronto, Canada (2010)
  • Travel Grant of the GlaxoSmithKline Foundation for the Annual Meeting of the American Academy of Neurology, Honolulu, USA (2011)
  • Travel Grant of the Felgenhauer Foundation for a 2-month research stay at the University of Syndey, Australia (2011)
  • Career Development Award of the University of Lübeck (2012-2013)
  • Travel Grant of the German Academic Exchange Service for attendance of the 16th Annual Conference in Dublin, Irland (2012)
  • Travel Award of the Movement Disorders Society for the 17th Annual Conference in Sydney, Australia (2013)

Aleksandar Rakovic, PhD

  • STIBET Fellowship of the German Academic Exchange Service (2007)

Philip Seibler, PhD

  • International Research Fellowship of the German Academic Exchange Service, Harvard Medical School, USA (2009)
  • Young Investigator Award of the German Society of Neurogenetics 2011

Irene Pichler, PhD

  • International Research Fellowship of the German Academic Exchange Service for a 6-month research stay at the Neurogenetics Section, University of Lübeck, Lübeck, Germany (2010)

Susanne A. Schneider, MD PhD

  • Graduate Scholarship of the Novartis Foundation for Therapeutic Research 2008
  • David Marsden Award 2009
  • John Stolk Movement Disorders Award of the American Academy of Neurology 2011
  • ‚Fast Track’ Program of the Robert Bosch Foundation (2011)

Meike Kasten, MD

  • International Research Fellowship of the Michael J. Fox Foundation, Parkinson Institute, Sunnyvale, USA (2006-2008)
  • Travel Grant of the Melvin Yahr International Parkinson’s Disease Foundation for the 18th WFN World Congress on Parkinson’s Disease and Related Disorders in Miami, USA (2009)
  • Career Development Award of the University of Lübeck (2012)

Norman Kock, MD

  • International Research Fellowship of the German Research Foundation (DFG), Harvard University, Boston, USA (2007)

Birgitt Schüle, MD

  • International Research Fellowship of the German Research Foundation (DFG), Stanford University, Stanford, USA (2007-2008)

Alexander Schmidt, MD

  • Travel Grant of the Movement Disorders Society for the 11th Annual Congress, Istanbul, Turkey (2007)

Norbert Brüggemann, MD

  • Travel Grant of the Movement Disorders Society for the 12th Annual Congress, Chicago, USA (2008) 
  • Travel Grant of the American Academy of Neurology (2009)
  • Travel Grant of the American Academy of Neurology (2010)
  • Travel Award of the Movement Disorders Society for the 15th Annual Conference in Toronto, Canada (2011)
  • International Research Grant from the German Research Foundation (DFG) for a research stay at the University of Copenhagen, Hvidovre, Danmark
  • Travel Award of the Movement Disorders Society for the 16th Annual Conference in Dublin, Irland (2012)

Kishore Kumar, MD

  • Dora Lush Postgraduate Research Scholarship of the National Health and Medical Research Council, Australia for a postdoctoral fellowship at the Neurogenetics Section, University of Lübeck (2011 – 2013)
  • Travel Award of the Movement Disorders Society for the 16th Annual Conference in Dublin, Irland (2012)

cand. med. Lisa Voges

  • Medical Thesis Stipend for Excellent Students of the University of Lübeck (2009–2010)
  • Travel Grant of the Melvin Yahr International Parkinson’s Disease Foundation for the 18th WFN World Congress on Parkinson’s Disease and Related Disorders in Miami, USA (2009)

Alexander Schmidt, MD

  • Heinrich Dräger Research Award 2010
  • Travel Award of the Movement Disorders Society for the 15th Annual Conference in Toronto, Canada (2011)
  • Junior Award for Clinical Research of the Movement Disorders Society 2011

Karen Grütz, née Freimann, MS

  • Travel Award of the Movement Disorders Society for the 16th Annual Conference in Dublin, Irland (2012)
  • Seahorse Travel Award for the 85th Annual Conference of the German Society, 2012

Anne Weißbach, MD

  • Travel Award of the Movement Disorders Society for the 16th Annual Conference in Dublin, Irland (2012)

Philipp Capetian, MD

  • Travel Award of the German Academic Exchange Services for attendance of the Annual Conference of the Society for Neuroscience in San Francisco, USA (2013)
  • Dystonia Research Network - Short Term Scientific Mission – Grant, 2015

Sinem Tunc, MD

  • Travel Award for attendance of the 1st Congress of the European Academy of Neurology

Aloysius Domingo, MD

  • Travel Award of the Movement Disorders Society for the 17th Annual Conference in Sydney, Australia (2013)
  • Travel Award of GlaxoSmithKline for the American Academy of Neurology Annual Meeting in Philadelphia, USA (2014)

Franca Vulinovic, MS

  • Travel Award of GlaxoSmithKline for the 17th Annual Conference of the Movement Disorders Society in Sydney, Australia (2013)
  • Junior Research Award der Deutschen Gesellschaft für Neurogenetik, 2015

cand. med. Alma Osmanovic

  • Medical Thesis Stipend for Excellent Students of the University of Lübeck (2010–2011)

cand.med. Sascha Heinitz

  • Medical Thesis Stipend for Excellent Students of the University of Lübeck (2011–2012)

cand. med. Juliane Vollstedt

  • Travel grant of the German Society of Psychiatry, Psychotherapy and Neurology for the Annual Congress (2011)

cand. med. Nils Uflacker

  • Medical Thesis Stipend for Excellent Students of the University of Lübeck (2011–2012)

cand. med. Björn Arns

  • Seahorse Travel Award for the 84th Annual Congress of the German Society of Neurology, Wiesbaden, 2011 
  • Uschi Tschabitzer Prize for Young Neurologists at the 16th Congress of the European Federation of Neurological Sciences, Stockholm, Sweden, 2012
Teaching and invited talks

Teaching

  • Neurology bedside teaching 
  • Neurology main lecture series (selected topics)
  • Case studies in movement and neurogenetic disorders
  • Seminar within the Master’s Program “Molecular Life Sciences” at the Natural Sciences Faculty
  • Neurogenetics seminar series
  • Neurobiomedicine lecture series 
  • Weekly journal club for graduate and undergraduate students
  • Lectures at international meetings and other Universities 
  • Faculty of the American Academy of Neurology since 2004 and director of the full-day teaching course on neurogenetics since 2009)
  • Editor of the Continuum (Lifelong Learning in Neurology) Issue on Neurogenetics 2008
  • Invitation to apply for the Editor-in-Chief position of Continuum (American Academy of Neurology, Dr. Griggs, 2011)

Habilitations

  • PD Dr. rer. nat. Katja Lohmann
  • PD Dr. med. Susanne Schneider, PhD
  • PD Dr. med. Norbert Brüggemann 
  • Dr. med. Alfredo Ramirez
  • Dr. med. Meike Kasten

Theses

  • 5 PhD Theses
  • 20 Medical Theses
  • 5 Master Theses
  • 7 Bachelor Theses
  • 1 Diploma paper

Mentoring

  • Mentoring of Graduate, Bachelor and Master students
  • Mentoring of two female clinician-scientists within career development programs for women of the University of Aachen and the Charite, Berlin

Invited Talks

  • 326 invited talks (1995-2015; 189 talks in Germany, 137 talks abroad)
List of plenary talks, selected invited talks, teaching courses
  1. Klein C. Genetics of the dystonias: The dopamine connection. The Mount Sinai Medical Center Lecture, Mount Sinai Medical Center, New York, USA, February 1999.

  2. Klein C. Clinical-genetic correlates in dystonia. Faculty of the Teaching Course "Update in dystonia" der Movement Disorder Society. VI. Annual Meeting of the Movement Disorder Society in Barcelona, Spain, June 2000.

  3. Klein C. Genetics of Parkinson's disease. Faculty of the teaching course: Genetics of Movement Disorders. 53rd Annual Meeting of the American Academy of Neurology, Philadelphia, USA, May 2001.

  4. Klein C. Molecular genetics of dystonia. Plenary Lecture at the 4th International Congress of the European Paediatric Neurology Society. Baden-Baden, Germany, September 2001.

  5. Klein C. Molekulare Krankheitsmodelle/Neurogenetik: Dystonien. Plenary Lecture at the 74th Congress of the German Society of Neurology. Aachen, Germany, September 2001.

  6. Klein C. The dopamine connection, imprinting, and haploinsufficiency – What is yet to come in dystonia and Parkinson genetics? Invited lecture, Mayo Clinic Jacksonville, Jacksonville, Florida, USA, March 2003.

  7. Klein C. Genetics of parkinsonism. Plenary lecture at the 35th Danube Symposium, Belgrad, Serbia and Montenegro, September 2003.

  8. Klein C. Genetics of Movement Disorders. Faculty of the teaching course Genetics in Neurology. 56th Annual Meeting of the American Academy of Neurology, San Francisco, USA, April 2004.

  9. Klein C. Movement disorders: Classifications. Plenary lecture at the 41st Annual Meeting of the Society for the Study of Inborn Errors of Metabolism Amsterdam, The Netherlands, September 2004.

  10. Klein C. Genetic and environmental factors in the etiology of Parkinson’s disease. Plenary lecture at the 9th Internationalen Congress of the Movement Disorder Society, New Orleans, USA, March 2005.

  11. Klein C. Genetics of movement disorders. Faculty of the teaching course “Genetics in Neurology” at the 57th Annual Meeting of the American Academy of Neurology, Miami, USA, April 2005.

  12. Klein C. The Genetics of Parkinson’s disease. Contemporary Clinical Issues and Case Studies Plenary Session. Plenary lecture at the 57th Annual Meeting of the American Academy of Neurology, Miami, USA, April 2005.

  13. Klein C. Early-onset parkinsonism (Parkin, DJ-1 and PINK1). Co-director of the teaching course “Genetics of parkinsonism” at the 16th International Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany, June, 2005.

  14. Klein C. Clinical and molecular genetics of Parkinson’s disease and dystonia: The dopamine connection. Lecture within the Mind Seminar Series, MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School, Boston,USA, September 2005.

  15. Klein C. Advances in the genetics of movement disorders are revolutionizing diagnosis. Plenary lecture at the 130th Annual Meeting of the American Neurological Association, San Diego, USA, September 2005.

  16. Klein C. Genetics of movement disorders. Faculty of the teaching course “Genetics in Neurology” at the 58th Annual Meeting of the American Academy of Neurology, San Diego, USA, April 2006.

  17. Klein C. Etiology of Parkinson’s disease. Faculty of the teaching course “Parkinson’s and Movement Disorders Update” at the 58th Annual Meeting of the American Academy of Neurology, San Diego, USA, April 2006.

  18. Klein C. Clinical spectrum of PINK1 mutations and evidence for a role of heterozygous mutations in a large family. Faculty of the teaching course “Case Studies in Neurogenetics” at the 58th Annual Meeting of the American Academy of Neurology, San Diego, USA, April 2006.

  19. Klein C. Clinical and molecular genetics of primary dystonia and dystonia-plus syndromes. Invited talk at the 2. NINDS-DMRF Workshop on Dystonia, Bethesda, USA, June 2006.

  20. Klein C. Heterozygous mutations cause autosomal recessive familial parkinsonism - YES. Plenary controversy at the 10th International Congress of the Movement Disorder Society, Kyoto, Japan, November 2006.

  21. Klein C. Genetics of movement disorders. Faculty of the teaching course “Genetics in Neurology” at the 59th Annual Meeting of the American Academy of Neurology, Boston, USA, April 2007.

  22. Klein C. Parkinson’s disease: Basic Science. Faculty of the teaching course “Parkinson’s and Movement Disorders Update” at the 59th Annual Meeting of the American Academy of Neurology, Boston, USA, April 2007.

  23. Klein C. Genetic Parkinson’s disease: Implications for neurological care. Plenary lecture at the Movement Disorder Society of Australia 2007 Conference, Gold Coast, Australia, October 2007.

  24. Klein C. Clinical and molecular genetics of dystonia and dystonia-plus syndromes. Plenary Lecture at the Movement Disorder Society of Australia 2007 Conference, Gold Coast, Australia, October 2007.

  25. Klein C. Clinical and molecular genetics of dystonia and dystonia-plus syndromes. Invited lecture, Basal Ganglia Club of the Institute of Neurology and Neurosurgery, Queen Square, London, England, November 2007.

  26. Klein C. Genetics of movement disorders. Faculty of the teaching course “Genetics in Neurology” at the 60th Annual Meeting of the American Academy of Neurology, Chicago, USA, April 2008.

  27. Klein C. Course director “Neurogenetics Case Presentations” at the 60th Annual Meeting of the American Academy of Neurology, Chicago, USA, April 2008.

  28. Klein C. Moderator of the “Highlights Session: Movement Disorders” at the 60th Annual Meeting of the American Academy of Neurology, Chicago, USA, April 2008.

  29. Klein C. Contribution of genetics to the understanding of Parkinson’s disease. Plenary lecture at the 7th National Congress of Parkinson’s Disease and Movement Disorders. Bodrum, Turkey, April 2008.

  30. Klein C. Deciphering the role of heterozygous mutations in recessive genes linked to parkinsonism: Common benign variants or susceptibility factor? Plenary lecture at the 133rd Annual Meeting of the American Neurological Association (Derek Denny-Brown Awardee), Salt Lake City, USA, September 2008.

  31. Klein C. Genetics of dystonia. Plenary lecture at the 14th Annual Meeting of the German Society of Neurogenetics. Lübeck, Germany, September 2008.

  32. Klein C. Parkinson’s disease genotypes and (endo-)phenotypes. Invited lecture at the National Hospital of Neurology, Queen Square, London, England, January 2009.

  33. Klein C. Introduction to neurogenetics. Course director of the teaching course “Genetics in Neurology” at the 61st Annual Meeting of the American Academy of Neurology, Seattle, USA, April 2009.

  34. Klein C. Neurogenetics: The European perspective. Faculty of the teaching course “Advances in genetics and molecular biology in global neurology” at the 61st Annual Meeting of the American Academy of Neurology, Seattle, USA, April 2009.

  35. Klein C. Is genetic testing for parkinsonism useful? – A (qualified) yes. Invited talk, WFN XVIII World Congress on Parkinson’s Disease and Related Disorders, Miami, USA, 2009.

  36. Klein C. Highlights of recent advances in neurogenetics and their impact on clinical practice, ethics, and health policies. Focus on Parkinson´s disease, movement disorders, and motor neuron disease. Invited talk at the 62nd Annual Meeting der American Academy of Neurology, Toronto, Canada, April 2010.

  37. Klein C. Genetic testing. Plenary lecture at the 2nd World Parkinson Congress, Glasgow, Great Britain, September 2010.

  38. Klein C. Parkinson´s disease: what genetics has taught us. Brendel Professorship at the University of Auckland, Auckland, New Zealand, February 2011.

  39. Klein C. Introduction and genetics of movement disorders. Course director of the teaching course “Genetics in Neurology” at the 63rd AAN Annual Meeting of the American Academy of Neurology, Honolulu, Hawaii, USA, April 2011.

  40. Klein C. Genetic aspects of Parkinson´s disease. Invited talk within the Integrated Neuroscience Session: Advances in the genetics of movement disorders auf dem 63rd AAN Annual Meeting of the American Academy of Neurology, Honolulu, Hawaii, USA, April 2011.

  41. Klein C. Parkinson’s disease: What genetics has taught us. Grand Rounds at the University of Calgary, Canada, June 2011.

  42. Klein C. Parkinson’s disease: What genetics has taught us. Keynote Lecture at the 4th Hope Conference der Parkinson Alberta Society und Parkinson Society of Canada, Calgary, Canada, June 2011.

  43. Klein C. Genes as risk factors for dystonia. Plenary lecture at the 5th International Dystonia Symposium, Barcelona, Spain, October 2011.

  44. Klein C. The role of causative and modifying genes in parkinsonism and dystonia. Invited speaker of the Basal Ganglia Club of the Institute of Neurology and Neurosurgery, Queen Square, London, England, December 2011.

  45. Klein C. MSSM Grand Rounds Dedicated to Melvin Yahr: Translating new findings in dystonia and Parkinson disease genetics into clincial practice. Invited named lecture at the Mount Sinai Medical School of Medicine, New York, USA, April 2012.

  46. Klein C. University of Ottawa Neuroscience Rounds: Translating movement disorders genetics into clincial practice. Invited Lecture at the University of Ottawa, Ottawa, Canada, May 2012.

  47. Klein C. What is more important: DYT phenotype or genotype? Invited plenary lecture at the 16. International Congress of the Movement Disorder Society, Dublin, Irleand, June 2012.

  48. Klein C. Vancouver Children’s Hospital Rounds: Genetics of dystonia and non-epileptic paroxysmal dyskinesia. Invited lecture at the University of British Columbia, Vancouver, Canada, July 2012.

  49. Klein C. Updates on X-linked dystonia-parkinsonism: Genetics. Invited plenary lecture at the 1. International Congress of the Movement Disorder Society of the Philippines, Manila, Philippines, August 2012.

  50. Klein C. Phenotypic presentations of genetic parkinsonism. Hot topics in movement disorders. Invited plenary lecture at the 16. Annual Meeting of the European Federation of the Neurological Sciences (EFNS), Stockholm, Sweden, September 2012.

Publications

Summary

Original articles: 264 (Total impact factor: 1445.7; Mean impact factor: 5.2)
Review articles: 45
Editorials: 11
Abstracts: 265

Medical Thesis

Klein C. Charakterisierung von mit der synaptischen Verbindung assoziierten Proteinen der Ratte. (Dissertationsarbeit bei der Medizinischen Fakultät der Universität Hamburg, 1995).

Habilitation Thesis

Klein C. Genetik der Dystonien und "Dystonie-plus"-Syndrome. (Habilitationsarbeit bei der Medizinischen Universität zu Lübeck, 2000).

Original articles
  1. Klein C, Wenning GK, Quinn NP. Pseudotransitorische ischämische Attacke als Erstsymptom bei Multisystematrophie. Nervenarzt 1995;2:133-135.

  2. Klein C, Wenning GK, Quinn NP, Marsden CD. Ataxia without telangiectasia masquerading as benign hereditary chorea. Mov Disord 1996;11:217-220.

  3. Vieregge P, Kaufmann U, Schäfer C, Steinauer K, Fey A, Klein C, Heberlein I, Zurloh A. Gangstörung als reduzierte sozial-praktische Kompetenz im Alter - Quantitative und Videofilm-gestützte Erfassung als Grundlage geriatrischer Rehabilitaion. Geriat Forsch 1996;6:123-140.

  4. Klein C, Vieregge P, Kömpf D. Paroxysmal choreoathetosis in a patient with idiopathic basal ganglia calcification, chorea and dystonia. Mov Disord 1997;12:254-255.

  5. Klein C, Brown R, Wenning GK, Quinn NP. The "cold hands sign" in multiple system atrophy. Mov Disord 1997;12:514-518.

  6. Klein C, Pulkowski U, Moser A, Kömpf D, Vieregge P. A study of visual hallucinations in patients with Parkinson´s disease. J Neurol 1997;244:371-377.

  7. Vieregge P, Klein C, Gehrking E, Körtke D, Kömpf D. The diagnosis of "essential palatal tremor". Neurology 1997;49:248-249.

  8. Vieregge P, Klein C, Heinzow B. Zur neurotoxikologischen Bewertung des Multiple Chemical Sensitivity (MCS)-Syndroms: Wie gelangen wir an reliable Ergebnisse? Gesundh-Wes 1997;59:413-414.

  9. Vieregge P, Stolze H, Klein C, Heberlein I. Gait quantitaion in Parkinson´s disease – Locomotor disability and correlation to clinical rating scales. J Neural Transm 1997;104:237-248.

  10. Wszolek ZK, Vieregge P, Uitti RJ, Gasser T, Yasuhara O, McGeer P, Calne DB, Vingerhoets FJG, Klein C, Pfeiffer RF. German-Canadian family (family A) with parkinsonism, amyotrophy, and dementia - longitudinal observations. Parkinsonism and Related Disorders 1997;3:125-139.

  11. Klein C, Vieregge P. Fahr’s disease - far from a disease. Mov Disord 1998;13:620-621.

  12. Klein C, Gehrking E, Vieregge P. Voluntary palatal tremor in two siblings. Mov Disord 1998;13:545-548.

  13. Klein C, Brin MF, de Leon D, Limborska SA, Ivanova-Smolenskaya IA, Bressman SB, Friedman J, Markova ED, Risch NJ, Breakefield XO, Ozelius LJ. De novo mutations (GAG deletion) in the DYT1 gene in two non-Jewish patients with early-onset dystonia. Hum Mol Genet 1998;7:1133-1136.

  14. Klein C, Pramstaller PP, Castellan CC, Breakefield XO, Kramer PL, Ozelius LJ. Clinical and genetic evaluation of a family with a mixed dystonia phenotype from South Tyrol. Ann Neurol 1998;44:394-398.

  15. Klein C, Vieregge P, Heide W, Kemper B, Hagedorn-Greiwe M, Hagenah J, Vollmer C, Breakefield XO, Kömpf D, Ozelius L. Exclusion of chromosome regions 6p12 and 15q11, but not chromosome region 7p11, in a German family with autosomal dominant congenital nystagmus. Genomics 1998;54:176-177.

  16. Klein C, Ozelius L, Hagenah J, Breakefield XO, Risch NJ, Vieregge P. Search for a founder mutation in idiopathic focal dystonia from Northern Germany. Am J Hum Genet 1998;63:1777-1782.

  17. Klein C, Page CE, LeWitt P, Gordon MF, de Leon D, Awaad Y, Breakefield XO, Brin MF, Ozelius LJ. Genetic analysis of three patients with an 18p- syndrome and dystonia. Neurology 1999;52:649-651.

  18. Klein C, Brin MF, Kramer P, Sena Esteves M, de Leon D, Doheny D, Bressman S, Fahn S, Breakefield XO, Ozelius LJ. Association of a missense change in the D2 dopamine receptor with myoclonus-dystonia. Proc Natl Acad Sci 1999;96:5173-5176.

  19. Hagenah J, Klein C, Sieberer M, Vieregge P. Exogenous levodopa is not toxic to elderly subjects with non-parkinsonian movement disorders: further clinical evidence. J Neural Transm 1999;106:301-307.

  20. Kramer PL, Mineta M, Klein C, Schilling K, de Leon D, Farlow MR, Breakefield XO, Bressman S, Dobyns WB, Ozelius LJ, Brashear A: Rapid-onset dystonia-parkinsonism: linkage to chromosome 19q13. Ann Neurol 1999;46:176-182.

  21. Vieregge P, Hagenah J, Heberlein I, Klein C, Ludin H-P. Parkinson’s disease in twins: a follow-up study. Neurology 1999;53:566-572.

  22. Nygaard TG, Raymond D, Chen C, Nishino I, Greene PE, Jennings D, Heiman GA, Klein C, Saunders-Pullman RJ, Kramer P, Ozelius LJ, Bressman SB. Localization of a gene for myoclonus-dystonia to chromosome 7q21-q31. Ann Neurol 1999;46:794-798.

  23. Sieberer MG, Vieregge P, Klein C, Ozelius LJ, Wandinger K-P. Concordant late onset of craniocervical dystonia in a pair of monozygotic twins. Mov Disord 1999;14:1040-1043.

  24. Klein C, Friedman J, Bressman S, Vieregge P, Brin MF, Pramstaller PP, de Leon D, Hagenah J, Sieberer M, Fleet C, Kiely R, Xin W, Breakefield XO, Ozelius LJ, Sims KB. Genetic testing for early-onset torsion dystonia (DYT1): Introduction of a simple screening method, experiences from testing of a large patient cohort, and ethical aspects. Genet Test 1999;3:323-328.

  25. Ozelius LJ, Page CE, Klein C, Hewett JW, Mineta M, Leung J, Shalish C, Bressman SB, de Leon D, Brin MF, Fahn S, Corey DP, Breakefield XO. The TOR1A (DYT1) gene family and role in early onset torsion dystonia. Genomics 1999;62:377-384.

  26. Klein C, Vieregge P, Hagenah J, Sieberer M, Doyle E, Jacobs H, Gasser T, Breakefield XO, Risch N, Ozelius LJ. Search for the PARK3 founder haplotype in a large cohort of patients with Parkinson’s disease from Northern Germany. Ann Hum Genet 1999;63:285-291.

  27. Klein C, Gurvich N, Sena-Esteves M, Bressman S, Brin MF, Camp SM, Ebersole BJ, Fink S, Forsgren L, Friedman J, Grimes D, Holmgren G, Kyllerman M, Lang AE, de Leon D, Leung J, Prioleau C, Raymond D, Sanner G, Saunders-Pullman R, Schilling K, Vieregge P, Wahlström J, Breakefield XO, Kramer PL, Ozelius LJ, Sealfon SC. Evaluation of the role of the D2 dopamine receptor in myoclonus-dystonia. Ann Neurol 2000;47:369-373.

  28. Vieregge P, Hagenah J, Heberlein I, Klein C, Ludin H-P. Parkinson's disease in twins. Neurology 2000;54:1710-1711.

  29. Bressman SB, Sabatti C, Raymond D, de Leon D, Klein C, Kramer PL, Brin MF, Fahn S, Breakefield XO, Ozelius LJ, Risch NJ. The DYT1 phenotype and guidelines for diagnostic testing. Neurology 2000;54:1746-1752.

  30. Klein C, Pramstaller PP, Kis B, Page C, Kann M, Leung J, Woodward H, Castellan CC, Scherer M, Vieregge P, Breakefield XO, Kramer PL, Ozelius LJ. Parkin deletions in a family with adult-onset, tremor-dominant parkinsonism: expanding the phenotype. Ann Neurol 2000;48:65-71.

  31. Klein C, Schumacher K, Jacobs H, Hagenah J, Kis B, Garrels J, Schwinger E, Ozelius L, Pramstaller P, Vieregge P, Kramer PL. Association studies of Parkinson’s disease and parkin polymorphisms. Ann Neurol 2000;48:126-127.

  32. Klein C, Schilling K, Saunders-Pullman RJ, Garrels J, Breakefield XO, Brin MF, deLeon D, Doheny D, Fahn S, Fink JS, Forsgren L, Friedman J, Frucht S, Harris J, Holmgren G, Kis B, Kurlan R, Kyllerman M, Lang AE, Leung J, Raymond D, Robishaw JD, Sanner G, Schwinger E, Tabamo RE, Tagliati M, Vieregge P, Wahlström J, Wendt KJ, Kramer PL, Bressman SB, Ozelius LJ. A major locus for myoclonus-dystonia maps to chromosome 7q in eight families. Am J Hum Genet 2000;67:1314-1319.

  33. Kis B, Heberlein I, Hagenah J, Jacobs H, Klein C, Vieregge P. Neuropsychological abnormalities in first degree relatives of patients with familial Parkinson's disease. J Neurol Neurosurg Psychiatry 2000;69:838.

  34. Friedman JRL, Klein C, Woodward H, Leung J, Ozelius LJ, Breakefield XO, Charness ME. The GAG deletion of the DYT1 gene is infrequent in musicians with focal dystonia. Neurology 2000;55:1417-1418.

  35. Hilker R, Klein C, Ghaemi M, Kis B, Strotmann T, Ozelius LJ, Lenz O, Vieregge P, Herholz K, Heiss W-D, Pramstaller PP. Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene. Ann Neurol 2001;49:367-376.

  36. Zühlke C, Hellenbroich Y, Dalski A, Kononowa N, Hagenah J, Vieregge P, Riess O, Klein C, Schwinger E. Different types of repeat expansion in the TATA-binding protein gene are associated with a new form of hereditary ataxia. Eur J Hum Genet 2001;9:160-164.

  37. Leung JC-o, Klein C, Friedman J, Vieregge P, Jacobs H, Doheny D, Kamm C, DeLeon D, Pramstaller PP, Jankovic J, Gasser T, Bressman SB, Corey DP, Kramer P, Brin MF, Ozelius LJ, Breakefield XO. Novel mutation in the TOR1A (DYT1) gene in atypical, early onset dystonia and polymorphisms in dystonia and early onset parkinsonism. Neurogenetics 2001;3:133-143.

  38. Hedrich K, Kann M, Lanthaler AJ, Dalski A, Eskelson C, Landt O, Schwinger E, Vieregge P, Lang AE, Breakefield XO, Ozelius LJ, Pramstaller PP, Klein C. The importance of gene dosage studies: Mutational analysis of the parkin gene in early-onset parkinsonism. Hum Mol Genet 2001;16:1649-1656.

  39. Klein C, Stewart GS, Quinn NP, Taylor MR. Ataxia without telangiectasia revisited: Update on genetic findings in two brothers with an ataxia-telangiectasia-like disorder. Mov Disord 2001;16:788-789.

  40. DeStefano AL, Golbe LI, Mark M, Lazzarini AM, Maher NE, Saint-Hilaire M, Feldman RG, Guttman M, Watts RL, Suchowersky O, Lafontaine AL, Labelle N, Lew MF, Waters CH, Growdon JH, Singer C, Currie LJ, Wooten GF, Vieregge P, Pramstaller PP, Klein C, Hubble JP, Stacy M, Montgomery E, MacDonald ME, Gusella JF, Myers RH. Genome-wide scan for parkinson's disease: The GenePD Study. Neurology 2001;57:1124-1126.

  41. Nitschke MF, Krüger G, Bruhn H, Klein C, Gehrking E, Wessel K, Frahm J, Vieregge P. Voluntary palatal tremor is associated with hyperactivation of the inferior olive - a fMRI study. Mov Disord 2001;16:1193-1195.

  42. Saunders-Pullman R, Shriberg J, Heiman G, Raymond D, Wendt K, Kramer P, Schilling K, Kurlan R, Klein C, Ozelius LJ, Risch NJ, Bressman SB. Myoclonus dystonia: Possible association with obsessive-compulsive disorder and alcohol dependence. Neurology 2002;58:242-245.

  43. Maher NE, Golbe LI, Lazzarini AM, Mark MH, Currie LJ, Wooten GF, Saint-Hilaire M, Wilk JB, Volcjak J, Mahre JE, Feldman RG, Guttman M, Lew M, Schuman S, Suchowersky O, Lafontaine AL, Labelle N, Vieregge P, Pramstaller PP, Klein C, Hubble J, Reider C, Growdon J, Watts R, Montgomery E, Baker K, Singer C, Stacy M, Myers RH. Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study. Neurology 2002;58:79-84.

  44. Kann M, Hedrich K, Marder K, Harris J, Meija-Santana H, Vieregge P, Jacobs H, Müller B, Kock N, Bressman SB, Lang AE, Schwinger E, Ozelius LJ, Pramstaller PP, Klein C. Late-onset Parkinson's disease: What is the role of the parkin gene? Neurology 2002;58:835.

  45. Pramstaller PP, Künig G, Leenders K, Kann M, Hedrich K, Goetz C, Vieregge P, Klein C. Mutations in the parkin gene associated with hemiparkinsonism-hemiatrophy: A clinical-genetic and PET study. Neurology 2002;58:808-810.

  46. Vitaliani R, Scaravilli T, Egarter-Vigl E, Giometto B, Klein C, Scaravilli F, An SF, Pramstaller PP. The pathology of the spinal cord in progressive supranuclear palsy. J Pathol Exp Neurol 2002;61:268-274.

  47. Hilker R, Klein C, Hedrich K, Ozelius LJ, Vieregge P, Herholz K, Pramstaller PP, Heiss W-D. The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans. Neurosci Lett 2002;323:50-54.

  48. Pramstaller PP, Kis B, Eskelson C, Hedrich K, Scherer M, Schwinger E, Vieregge P, Breakefield XO, Kramer PL, Ozelius LJ, Klein C. Phenotypic variability in a large kindred (Family LA) with deletions in the parkin gene. Mov Disord 2002;17:424-426.

  49. Kann M, Vieregge P, Jacobs H, Mohrmann K, Schumacher K, Hedrich K, Garrels J, Schwinger E, Pramstaller PP, Breakefield XO, Ozelius LJ, Klein C. The role of parkin mutations in 111 community-derived patients with early-onset parkinsonism. Ann Neurol 2002;51:621-625.

  50. DeStefano AL, Lew MF, Golbe LI, Mark MH, Lazzarini AM, Guttman M, Montgomery E, Waters CH, Singer C, Watts RL, Currie LJ, Wooten F, Maher NE, Wilk JB, Sullivan KM, Slater KM, Saint-Hilaire MH, Feldman RG, Suchowersky O, Lafontaine A-L, Labelle N, Growdon JH, Vieregge P, Pramstaller PP, Klein C, Hubble JP, Reider CR, Stacy M, MacDonald ME, Gusella JF, Myers RH. PARK3 influences Parkinson's disease onset age: A genome scan in the GenePD Study. Am J Hum Genet 2002;70:1089-1095.

  51. Hedrich K, Marder K, Harris J., Kann M, Lynch T, Meija-Santana H, Pramstaller PP, Schwinger E, Bressman SB, Fahn S, Klein C. Evaluation of 50 probands with early-onset Parkinson´s disease for parkin mutations. Neurology 2002;58:1239-1246.

  52. Kock N, Culjkovic B, Maniak S, Schilling K, Müller B, Zühlke C, Ozelius L, Klein C, Pramstaller PP, Kramer PL. Mode of inheritance and susceptibility locus for restless legs syndrome on chromosome 12q. Am J Hum Genet 2002;71:205-208.

  53. Kis B, Schrag A, Ben-Shlomo Y, Klein C, Gasperi A, Spoegler F, Schoenhuber R, Pramstaller PP. Prevalence of Parkinson's disease and parkinsonism in South Tyrol. Neurology 2002;58:1820-1825.

  54. Augood SJ, Hollingsworth Z, Albers DS, Yang L, Leung JC, Muller B, Klein C, Breakefield XO, Standaert DG. Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study. Neurology 2002;59:445-448.

  55. Kock N, Müller B, Vieregge P, Pramstaller PP, Marder K, Abbuzzese G, Martinelli P, Lang AE, Jacobs H, Hagenah J, Harris J, Meija-Santana H, Fahn S, Hedrich K, Kann M, Gehlken U, Culjkovic B, Schwinger E, Wszolek ZW, Zühlke C, Klein C. Role of SCA-2 mutations in early- and late-onset dopa-responsive parkinsonism. Ann Neurol 2002;52:257-258.

  56. Bubel S, Peters V, Klein C, Hackler R, Schaefer JR, Hagenah J, Hoffmann GF, Vieregge P. CDG (congenital disorders of glycosylation) – Zur Differentialdiagnose hereditärer Ataxien im Erwachsenenalter. Nervenarzt 2002;73:754-760.

  57. Pal PK, Leung J, Hedrich K, Samii A, Lieberman A, Nausieda PA, Calne DB, Breakefield XO, Klein C, Stoessl AJ. [18F]-Dopa PET imaging in early stage, non-parkin juvenile parkinsonism. Mov Disord 2002;17:789-794.

  58. Doheny D, Danisi F, Smith C, Morrison C, Velickovic M, de Leon D, Bressman SB, Leung J, Ozelius L, Klein C, Breakefield XO, Silverman J, Brin MF. Clinical findings of a myoclonus-dystonia family with two distinct mutations. Neurology 2002;59:1244-1246.

  59. Doheny DO, Brin MF, Morrison CE, Smith CJ, Walker RH, Abbasi S, Müller B, Garrels J, Liu L, de Carvalho Aguiar P, Schilling K, Kramer P, de Leon D, Raymond D, Saunders-Pullman R, Ozelius LJ, Klein C, Bressman SB, Schmand B, de Koning-Tijssen MAJ, Silverman JM. Phenotypic features of myoclonus-dystonia in three kindreds. Neurology 2002;59:1187-1196.

  60. Klein C, Liu L, Doheny D, Kock N, Müller B, de Carvalho Aguiar P, Leung J, de Leon D, Bressman SB, Silverman J, Smith C, Danisi F, Morrison C, Walker RH, Velickovic M, Schwinger E, Kramer PL, Breakefield XO, Brin MF, Ozelius LJ. Epsilon-Sarcoglycan mutations found in combination with other dystonia gene mutations. Ann Neurol 2002;52:675-679.

  61. Klein C, Hedrich K, Kabakçi K, Mohrmann K, Wiegers K, Landt O, Schwinger E, Pramstaller PP, Ozelius LJ, Gucuyener K, Aysun S, Demir E. Exon deletions in the GCH1 gene in two of four Turkish families with dopa-responsive dystonia. Neurology 2002;59:1783-1786.

  62. Müller B, Hedrich K, Kock N, Dragasevic N, Svetel M, Garrels J, Landt O, Nitschke M, Pramstaller PP, Reik W, Schwinger E, Sperner J, Ozelius L, Kostic V, Klein C. Evidence for paternal expression of the epsilon-sarcoglycan gene explains reduced penetrance in myoclonus-dystonia. Am J Hum Genet 2002;71:1303-1311.

  63. Maniak S, Sieberer M, Hagenah J, Klein C, Vieregge P. Focal and segmental primary dystonia in north-western Germany – a clinico-genetic study. Acta Neurol Scand 2003;107:228-232.

  64. Lincoln S, Wiley J, Lynch T, Langston W, Chen R, Lang A, Rogaeva E, Harris J, Marder K, Klein C, Bisceglio G, Hussey J, West A, Hulihan M, Hardy J, Farrer M. Parkin proven disease: common founders but divergent phenotypes. Neurology 2003;60:1605-1610.

  65. Foncke EMJ, Klein C, Koelman JHTM, Kramer PL, Schilling K, Müller B, Garrels J, de Carvalho Aguiar P, Liu L, de Froe A, Speelman JD, Ozelius LJ, Tijssen MAJ. Hereditary dystonia associated with epilepsy. Neurology 2003;60:1988-1990.

  66. Klein C, Hedrich K, Wellenbrock C, Kann M, Harris J, Marder K, Lang AE, Schwinger E, Ozelius LJ, Vieregge P, Pramstaller PP, Kramer PL. Frequency of Parkin mutations in late-onset Parkinson’s disease. Ann Neurol 2003;54:415-416.

  67. Wellenbrock C, Hedrich K, Schäfer N, Kasten M, Jacobs H, Schwinger E, Hagenah J, Pramstaller PP, Vieregge P, Klein C. NR4A2 mutations are rare among European patients with familial Parkinson’s disease. Ann Neurol 2003;54:415.

  68. Karamohamed S, DeStefano AL, Wilk JB, Shoemaker CM, Golbe LI, Mark MH, Lazzarini AM, Guttman M, Montgomery E, Baker K, Lew M, Singer C, Watts R, Currie LJ, Wooten GF, Saint-Hilaire M, Feldman RG, Sullivan KM, Xu G, Perlmutter J, Racette B, Parsian A, Suchowersky O, Lafontaine AL, Labelle N, Growdon J, Vieregge P, Pramstaller P, Klein C, Stacy M, Gusella JF, Fink SJ, Myers RH, Herbert, A. A haplotype at the PARK3 locus influences onset age for Parkinson disease: The GenePD study. Neurology 2003;61:1557-1561.

  69. Denison SR, Wang F, Becker NA, Schüle B, Kock N, Phillips LA, Klein C, Smith DI. Alterations in the common fragile site gene parkin in ovarian and other cancers. Oncogene 2003;22:8370-8378.

  70. Hedrich K, Schäfer N, Hering R, Hagenah J, Lanthaler AJ, Schwinger E, Kramer PL, Ozelius LJ, Bressman S, Abbruzzese G, Martinelli P, Kostic V, Pramstaller PP, Vieregge P, Riess O, Klein C. The R98Q variation in DJ-1 represents a rare polymorphism. Ann Neurol 2004;55:145.

  71. Hedrich K, Djarmati A, Schäfer N, Hering R, Wellenbrock C, Weiss PH, Hilker R, Vieregge P, Ozelius LJ, Heutink P, Bonifati V, Schwinger E, Lang AE, Noth J, Bressman SB, Pramstaller PP, Riess O, Klein C. DJ-1 mutations are less frequent than Parkin mutations in early-onset Parkinson’s disease. Neurology 2004;62:389-394.

  72. Kabakci K, Hedrich K, Leung JC, Mitterer M, Vieregge P, Lencer R, Hagenah J, Garrels J, Witt K, Klostermann F, Svetel M, Friedman J, Kostic V, Bressman SB, Breakefield XO, Ozelius LJ, Pramstaller PP, Klein C. Mutations in DYT1: Extension of the phenotypic and mutational spectrum. Neurology 2004;62:395-400.

  73. Kock N, Kasten M, Schüle B, Hedrich K, Wiegers K, Kabakci K, Pramstaller PP, Nitschke MS, Sperner J, Klein C. Clinical and genetic features of myoclonus-dystonia in three cases: a video presentation. Mov Disord 2004;19:231-234.

  74. Hagenah J, Zühlke C, Hellenbroich Y, Heide W, Klein C. Focal dystonia as presenting sign of SCA17. Mov Disord 2004;19:217-220.

  75. Hedrich K, Meyer E-M, Schüle B, Kock N, de Carvalho Aguiar P, Wiegers K, Koelman JH, Garrels J, Dürr R, Liu L, Schwinger E, Ozelius LJ, Landwehrmeyer B, Stoessl, Tijssen MAJ, Klein C. Myoclonus-dystonia: Detection of novel, recurrent, and de novo SGCE mutations. Neurology 2004;62:1229-1231.

  76. Kahl KG, Hagenah J, Zapf S, Trillenberg P, Klein C, Lencer R. Botulinum toxin as an effective treatment of clozapine-induced hypersalivation. Psychopharmacol 2004;173:229-230.

  77. Wang F, Denison S, Hall C, Kock N, Schüle B, Klein C, Shridhar V, Smith DI. Loss of Parkin expression in hepatocellular carcinoma cells and its association with the cytoskeleton. Gene Chromosome Canc 2004;40:85-96.

  78. Djarmati A, Hedrich K, Schäfer N, Juric V, Vukosavic S, Hering R, Riess O, Romac S, Klein C, Kostic V. Frequency of Parkin and DJ-1 mutations depends on ethnic origin of Parkinson’s disease patients. Hum Mut 2004;23:525.

  79. Schüle B, Kock N, Svetel M, Dragasevic N, Hedrich K, de Carvalho Aguiar P, Liu L, Kabakci K, Garrels J, Meyer E-M, Berisavac I, Schwinger E, Kramer PL, Ozelius LJ, Klein C, Kostic V. Genetic heterogeneity in ten families with myoclonus-dystonia. J Neurol Neurosurg Psychiatry 2004;75:1181-1185.

  80. Hering R, Strauss KM, Tao X, Bauer A, Woitalla D, Mietz E-M, Petrovic S, Bauer P, Schaible W, Müller T, Schöls L, Klein C, Berg D, Meyer PT, Schulz JB, Wollnik B, Tong L, Krüger R, Riess O. Novel homozygous E64D mutation in DJ1 in early onset Parkinson disease (PARK7). Hum Mut 2004;24:321-329.

  81. Hedrich K, Eskelson C, Wilmot B, Marder K, Harris J, Garrels J, Meija-Santana H, Vieregge P, Jacobs H, Bressman SB, Lang AE, Kann M, Abbruzzese G, Martinelli P, Schwinger E, Ozelius LJ, Pramstaller PP, Klein C, Kramer P. Distribution and origin of Parkin mutations: Review and case studies. Mov Disord 2004;19:1146-1157.

  82. Walter U, Klein C, Hilker R, Benecke R, Pramstaller PP, Dressler D. Brain parenchyma sonography detects preclinical parkinsonism. Mov Disord 2004;19:1445-1449.

  83. Saunders-Pullman R, Blau N, Hyland K, Zschocke J, Nygaard T, Raymond D, Shanker V, Mohrmann K, Arnold L, Tabbal S, deLeon D, Ford B, Brin M, Chouinard S, Ozelius L, Klein C, Bressman SB. Phenylalanine loading as a diagnostic test for DRD: Interpreting the utility of the test. Mol Genet Metab 2004;83:207-212.

  84. Lencer R, Eismann G, Kasten M, Kabakci K, Geithe V, Grimm J, Klein C. Family history of primary movement disorders as a predictor for neuroleptic-induced extrapyramidal symptoms. Brit J Psychiat 2004;185:465-471.

  85. Hagenah J, Saunders-Pullman R, Hedrich K, Kabakci K, Habermann K, Wiegers K, Mohrmann K, Lohnau T, Raymond D, Vieregge P, Nygaard T, Ozelius LJ, Bresmman SB, Klein C. High mutation rate in dopa-responsive dystonia with comprehensive GCHI screening. Neurology 2005;64:908-911.

  86. Kahl KG, Trillenberg P, Kordon A, Lencer R, Klein C, Hagenah J. Therapie der Clozapin-induzierten Hypersalivation mit Botulinum-Toxin B – eine Kasuistik. Nervenarzt 2005;76:205-208.

  87. Kabakci K, Isbruch K, Schilling K, Hedrich K, de Carvalho Aguiar P, Ozelius LJ, Kramer PL, Schwarz MHRM, Klein C. Genetic heterogeneity in rapid-onset dystonia-parkinsonism: Description of a new family. J Neurol Neurosurg Psychiatry 2005;76:860-862.

  88. Berg D, Niwar M, Maass S, Zimprich A, Möller JC, Wuellner U, Schmitz-Hübsch T, Klein C, Tan EK, Schöls L, Marsh L, Dawson TM, Janetzky B, Müller T, Woitalla D, Kostic V, Pramstaller PP, Oertel W, Bauer P, Krueger R, Gasser T, Riess O. Alpha-synuclein and Parkinson’s disease – implications from the screening of more than 1900 patients. Mov Disord 2005;20:1191-1194.

  89. Hedrich K, Pramstaller PP, Stübke K, Hiller A, Kabakci K, Purmann S, Kasten M, Scaglione C, Schwinger E, Volkmann J, Kostic V, Vieregge P, Martinelli P, Abbruzzese G, Klein C, Zühlke C. Premutations in the FMR1 gene as a modifying factor in Parkin-associated parkinsonism? Mov Disord 2005;20:1060-1062.

  90. Karamohamed S, Golbe LI, Mark MH, Lazzarini AM, Suchowersky O, Labelle N, Guttman, M, Currie LJ, Wooten GF, Stacy M, Saint-Hilaire M, Feldman RG, Liu J, Shoemaker CM, Wilk JB, DeStefano AL, Latourelle JC, Xu G, Watts R, Growdon J, Lew M, Waters C, Vieregge P, Pramstaller PPP, Klein C, Racette BA, Perlmutter JS, Parsian A, Singer C, Montgomery E, Baker K, Gusella JF, Herbert A, Myers RH. Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson’s disease from the GenePD study. Mov Disord 2005;20:1188-1191.

  91. Klein C, Djarmati A, Hedrich K, Schäfer N, Scaglione C, Marchese R, Kock N, Schüle B, Lohnau T, Winkler S, Wiegers K, Hering R, Bauer P, Riess O, Abbruzzese G, Martinelli P, Pramstaller PP. PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism. Eur J Hum Genet 2005;13:1086-1093.

  92. Pramstaller PP, Schlossmacher MG, Jacques TS, Scaravilli F, Eskelson C, Pepivani I, Hedrich K, Adel S, Gonzales-McNeal M, Hilker R, Kramer PL, Klein C. Lewy body Parkinson disease in a large pedigree with 77 Parkin mutation carriers. Ann Neurol 2005;58:411-422.

  93. Kis, B, Hedrich K, Kann M, Schwinger E, Kömpf D, Klein C, Pramstaller P. Oculogyric dystonic states in early-onset parkinsonism with basal ganglia calcifications. Neurology 2005;65:761.

  94. Djarmati A, Svetel M, Momcilovic D, Kostic V, Klein C. Significance of recurrent mutations in the myofibrillogenesis regulator 1 gene. Arch Neurol 2005;62:1641.

  95. Buhmann C, Binkofski F, Klein C, Büchel C, van Eimeren T, Erdmann C, Hedrich K, Kasten M, Hagenah J, Deuschl G, Pramstaller PP, Siebner HR. Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic parkinsonism. Brain 2005;128:2281-2290.

  96. Karamohamed S, Latourelle JC, Racette BA, Perlmutter JS, Wooten GF, Lew M, Klein C, Shill H, Golbe LI, Mark MH, Guttman M, Nicholson G, Wilk JB, Saint-Hilaire M, DeStefano AL, Prakash R, Tobin S, Williamson J, Suchowersky O, Labell N, Growdon BN, Singer C, Watts R, Goldwurm S, Pezzoli G, Baker KB, Giroux ML, Pramstaller PP, Burn DJ, Chinnery P, Sherman S, Vieregge P, Litvan I, Gusella JF, Myers RH, Parsian A. BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Neurology. 2005;65:1823-1825.

  97. Van Hove JLK, Steyaert J, Matthijs G, Legius E, Theys P, Wevers R, Romstad A, Moller LB, Hedrich K, Goriounov D, Blau N, Klein C, Casaer P. Expanded motor and psychiatric phenotype in autosomal dominant Segawa syndrome due to GTP cyclohydrolase deficiency. J Neurol Neurosurg Psychiatry 2006;77:18-23.

  98. Ozelius LJ, Saunders-Pullman R, Ohmann E, Deligtisch A, Tagliati M, Hunt AL, Klein C, Henick B, Hailpern SM, Lipton RB, Soto-Valencia J, Risch N, Bressman S. LRRK2 G2019S as a cause of Parkinson’s disease in Ashkenazi Jews. New Engl J Med 2006;354:424-425.

  99. Dragasevic NT, Culjkovic B, Klein C, Ristic A, Keckarevic M, Topisirovic I, Vukosavic S, Svetel M, Kock N, Stefanova E, Romac S, Kostic VS. Frequency analysis and clinical characterization of different types of spinocerebellar ataxia in Serbian patients. Mov Disord 2006;21:187-191.

  100. Adel S, Djarmati A, Kabakci K, Pichler I, Eskelson C, Lohnau T, Kock N, Hagenah J, Hedrich K, Schwinger E, Kramer PL, Pramstaller PP, Klein C. Co-occurrence of restless legs syndrome and Parkin mutations in two families. Mov Disord 2006;21:258-263.

  101. Gerrits MC, Foncke EM, de Haan R, Hedrich K, van de Leemput YL, Baas F, Ozelius LJ, Speelman JD, Klein C, Tijssen MA. Phenotype-genotype correlation in Dutch patients with myoclonus-dystonia. Neurology 2006;66:759-761.

  102. Zadikoff C, Rogaeva E, Djarmati A, Sato C, Salehi-Rad S, St. George-Hyslop P, Klein C, Lang AE. Homozygous and heterozygous PINK1 mutations:  Considerations for diagnosis and care of Parkinson’s disease patients. Mov Disord 2006;21:875-879.

  103. Klein C, Grünewald A, Hedrich K. Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. Neurology 2006;66:1129-1130.

  104. Hedrich K, Hagenah J, Djarmati A, Hiller A, Lohnau T, Lasek K, Grünewald A, Hilker R, Steinlechner S, Boston H, Kock N, Schneider-Gold C, Kress W, Siebner H, Binkofski F, Lencer R, Münchau A, Klein C. Clinical spectrum of homo-and heterozygous PINK1 mutations in a large German family with Parkinson’s disease: Role of a single hit? Arch Neurol 2006;63:833-838.

  105. Sun M, Latourelle JC, Wooten GF, Lew MF, Klein C, Shill HA, Golbe LI, Mark MH, Racette BA, Perlmutter JS, Parsian A, Guttman M, Nicholson G, Xu G, Wilk JB, Saint-Hilaire MH, DeStefano AL, Prakash R, Williamson S, Suchowersky O, Labelle N, Growdon JH, Singer C, Watts RL, Goldwurm S, Pezzoli G, Baker KB, Pramstaller PP, Burn DJ, Chinnery PF, Sherman S, Vieregge P, Litvan I, Gillis T, MacDonald ME, Myers RH, Gusella JF. Heterozygosity for Parkin mutation influences onset age in familial Parkinson’s disease: The GenePD Study. Arch Neurol 2006;63:826-832. 

  106. Nitschke MF, Erdmann C, Trillenberg P, Sprenger A, Kock N, Sperner J, Klein C. Functional MRI reveals activation of a subcortical network in a 5-year old girl with genetically confirmed myoclonus-dystonia. Neuropediatrics 2006;37:79-82.

  107. Hagenah JM, Hedrich K, Becker B, Pramstaller PP, Seidel G, Klein C. Distinguishing early-onset PD from dopa-responsive dystonia with transcranial sonography. Neurology 2006;66:1951-1952.

  108. Pichler I, Marroni F, Volpato CB, Gusella JF, Klein C, Casari G, De Grandi A, Pramstaller PP. Linkage analysis identifies a novel locus for restless legs syndrome on chromosome 2q in a South Tyrolean population isolate. Am J Hum Genet 2006;79:716-723.

  109. Schmidt A, Jabusch H-C, Altenmüller E, Hagenah J, Brüggemann N, Hedrich K, Saunders-Pullman R, Bressman SB, Kramer PL, Klein C. Dominantly transmitted focal dystonia in families of patients with musician’s cramp. Neurology 2006;67:691-693.

  110. Helmchen C, Schwekendiek A, Pramstaller P, Hedrich K, Klein C, Rambold H. Blink amplitude but not saccade hypometria indicates carriers of Parkin mutations J Neurol 2006;253:1071-1075.

  111. Foncke EM, Gerrits MC, van Ruissen F, Baas F, Hedrich K, Tijssen CC, Klein C, Tijssen MA. Distal myoclonus and late onset in a large Dutch family with myoclonus-dystonia. Neurology 2006;67:1677-1680.

  112. Vogl FD, Pichler I, Adel S, Pinggera GK, Bracco S, De Grandi A, Beu Volpato C, Aridon P, Mayer T, Meitinger T, Klein C, Casari G, Pramstaller PP. Restless legs syndrome: epidemiological and clinico-genetic study in a South Tyrolean population isolate. Mov Disord 2006;21(8):1189-95.

  113. Djarmati A, Hedrich K, Svetel M, Lohnau T, Schwinger E, Romac S, Pramstaller PP, Kostic V, Klein C. Heterozygous PINK1 mutations: A susceptibility factor for Parkinson disease? Mov Disord 2006;21:1526-1530.

  114. Hedrich K, Winkler S, Hagenah J, Kabakci K, Kasten M, Schwinger E, Volkmann J, Pramstaller PP, Kostic V, Vieregge P, Klein C. Recurrent LRRK2 (PARK8) mutations occur in early-onset Parkinson´s disease. Mov Disord 2006;21:1506-1510.

  115. Lasek K, Lencer R, Gaser C, Hagenah J, Walter U, Wolters A, Kock N, Steinlechner S, Nagel M, Zühlke C, Nitschke M-F, Brockmann K, Klein C, Rolfs A, Binkofski F. Morphological basis for the spectrum of clinical deficits in spinocerebellar ataxia 17 (SCA17). Brain 2006;129:2341-2352.

  116. Kostic V, Svetel M, Kabakci K, Ristic A, Petrovic I, Schüle B, Kock N, Djarmati A, Romac S, Klein C. Intrafamilial phenotypic and genetic heterogeneity of dystonia. J Neurol Sci 2006;2501-2):92-6.

  117. Wilk JB, Tobin JE, Suchowersky O, Shill H, Klein C, Wooten GF, Lew M, Mark MH, Guttman M, Watts RL, Singer C, Growdon J, Latourelle JC, Saint-Hilaire M, DeStefano AL, Prakash R, Williamson S, Berg CJ, Sun M, Goldwurm S, Pezzoli G, Racette BA, Perlmutter JS, Parsian A, Baker K, Giroux ML, Litvan I, Pramstaller PP, Nicholson GA, Burn DJ, Chinnery PF, Vieregge P, Slevin JT, Cambi F, MacDonald ME, Gusella JF, Myers RH, Golbe LI. Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: The GenePD Study. Neurology 2006;67:2206-2210.

  118. Stefanova E, Djarmati A, Momcilovic D, Svetel M, Klein C, Kostic VS. Clinical characteristics of paroxysmal nonkinesigenic dyskinesia in a Serbian family with a Myofibrillogenesis regulator 1 gene mutation. Mov Disord 2006;21:2010-2015.

  119. Kemlink D, Polo O, Montagna P, Provini F, Stiasny-Kolster K, Oertel W, de Weerd A, Nevsimalova S, Sonka K, Högl B, Frauscher B, Poewe W, Trenkwalder C, Pramstaller PP, Ferini-Strambi L, Zucconi M, Konofal E, Arnulf I, Hadjigeorgiou GM, Happe S, Klein C, Hiller A, Lichtner P, Meitinger T, Müller-Myshok B, Winkelmann J. A family-based association study of the restless legs syndrome loci 2 and 3 in a European population. Mov Disord 2007;22:207-212.

  120. Brashear A, Dobyns WB, de Carvalho Aguiar P, Borg M, Frijns CJM, Gollamudi S, Green A, Guimaraes J, Haake BC, Klein C, Linazasoro G, Münchau A, Raymond D, Riley D, Saunders-Pullman R, Tijssen MAJ, Webb D, Zaremba J, Bressman SB, Ozelius LJ. The phenotypic spectrum of rapid-onset dystonia parkinsonism (RDP) and mutations in the ATP1A3 gene. Brain 2007;130:828-835.

  121. Grünewald A, Breedveld GJ, Hedrich-Lohmann K, Rohe CF, König IR, Hagenah J, Vanacore N, Meco G, Antonini A, Goldwurm S, Lesage S, Dürr A, Binkofski F, Siebner H, Münchau A, Brice A, Oostra BA, Klein C, Bonifati V. Biological effects of the PINK1 c.1366C>T mutation: Implications in Parkinson disease pathogenesis. Neurogenetics 2007;8:103-109.

  122. Hess CW, Raymond D, de Carvalho Aguiar P, Frucht S, Shriberg J, Heiman GA, Kurlan R, Klein C, Bressman SB, Ozelius, Saunders-Pullman R. Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers. Neurology 2007;68:522-524.

  123. Eggert K, Wüllner U, Anthony G, Gasser T, Janetzky B, Klein C, Schöls L, Oertel WH. The model of GEPARD (Gene Bank Parkinson’s Disease Germany). Mov Disord 2007;22:611-618.

  124. Steinlechner S, Stahlberg J, Völkel B, Djarmati A, Hagenah J, Hiller A, Hedrich K, König I, Klein C, Lencer R. Co-occurrence of affective and schizophrenia spectrum disorders with PINK1 mutations. J Neurol Neurosurg Psychiatry 2007;78:532-535.

  125. Clark LN, Haamer E, Mejia-Santana H, Harris J, Lesage S, Durr A, Janin S, Hedrich K, Louis ED, Cote LC, Andrews H, Fahn S, Waters C, Ford B, Frucht S, Scott W, Klein C, Brice A, Roomere H, Ottman R, Marder K. Mutation genotyping array for the Parkin gene. Movement Disorders 2007;22:932-937.

  126. Klein C, Lohmann-Hedrich K, Rogaeva E, Schlossmacher MG, Lang AE. Deciphering the role of heterozygous mutations in genes associated with parkinsonism. Lancet Neurol 2007;6:652-662.

  127. Hagenah JM, Reetz K, Zühlke C, Rolfs A, Binkofski F, Klein C. Predominant dystonia with marked cerebellar atrophy. Neurology 2007;68:2157-2158.

  128. Binkofski F, Reetz K, Gaser C, Hilker R, Hagenah J, Hedrich K, v Eimeren T, Thiel A, Büchel C, Pramstaller PP, Siebner HR, Klein C. Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia. Neurology 2007;69:842-850.

  129. Hübner J, Sprenger A, Klein C, Hagneah J, Rambold H, Zühlke C, Kömpf D, Rolfs A, Kommig H, Helmchen C. Eye movement abnormalities in spinocerebellar ataxia type 17 (SCA17). Neurology 2007;69:1160-1168.

  130. Bäumer T, Pramstaller PP, Schippling S, Hagenah J, Peller M, Gerloff C, Siebner HR, Klein C, Münchau A. Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers – a TMS study. Neurology 2007;69:1976-1981.

  131. Djarmati A, Guzvic M, Grünewald A, Lang AE, Pramstaller PP, Simon DK, Kaindl AM, Vieregge P, Nygren AOH, Beetz C, Hedrich K, Klein C. Rapid and reliable detection of exon rearrangements in various movement disorders genes by multiplex ligation-dependent probe amplification. Mov Disord 2007;22:1708-1714.

  132. Winkler S, Hagenah J, Lincoln S, Heckman M, Haugarvoll K, Lohmann-Hedrich K, Kostic V, Farrer M, Klein C. Alphaa-Synuclein and Parkinson’s disease susceptibility. Neurology 2007;69:1745-1750.

  133. Hagenah JM, König IR, Becker B, Hilker R, Kasten M, Hedrich K, Pramstaller PP, Klein C, Seidel G. Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles. J Neurol 2007;254:1407-1413.

  134. Winkler S, König I, Lohmann-Hedrich K, Vieregge P, Kostic V, Klein C. Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson disease. Eur J Hum Genet 2007;15:1163-1168.

  135. Orth M, Djarmati A, Bäumer T, Winkler S, Grünewald A, Lohmann-Hedrich K, Kabakci K, Hagenah J, Klein C, Münchau A. Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE gene. Mov Disord 2007;22:2090-2096.

  136. Haugarvoll K, Rademakers R, Kachergus JM, Nuytemans K, Ross OA, Gibson M, Tan E-K, Gaig C, Tolosa E, Goldwurm S, Guidi M, Riboldazzi G, Brown L, Walter U, Benecke R, Berg D, Gasser T, Theuns J, Pals P, Cras P, De Deyn PP, Engelborghs S, Pickut B, Uitti RJ, Foroud T, Nichols WC, Hagenah J, Klein C, Samii A, Zabetian CP, Bonifati V, van Broeckhoven C, Farrer MJ, Wszolek ZK. Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson’s disease. Neurology 2008;70:1456-1460. 

  137. Lohmann-Hedrich K, Neumann A, Kleensang A, Lohnau T, Muhle H, Djarmati A, König I, Pramstaller PP, Schwinger E, Kramer PL, Ziegler A, Stephani U, Klein C. Evidence for linkage of restless legs syndrome to chromosome 9p: Are there two distinct loci? Neurology 2008;70:686-694.

  138. Moro E, Volkmann J, König IR, Winkler S, Hiller A, Hassin-Baer S, Herzog J, Schnitzler A, Lohman K, Pinsker MO, Voges J, Djarmati A, Seibler P, Lozano AM, Rogaeva E, Lang AE, Deuschl G, Klein C. Bilateral subthalamic stimulation in Parkin and PINK1 parkinsonism. Neurology 2008;70:1186-1191.

  139. Paus S, Grünewald A, Klein C, Knapp M, Zimprich A, Janetzky B, Möller C, Klockgether T, Wüllner U. The DRD TaqIA polymorphism and demand of dopaminergic medication in Parkinson’s disease. Mov Disord 2008;23:599-602. 

  140. Raymond D, Saunders-Pullman R, de Carvalho Aguiar P, Schule B, Kock N, Friedman J, Harris J, Ford B, Frucht S, Heiman GA, Jennings D, Doheny D, Brin MF, de Leon D, Multhaupt-Buell T, Lang AE, Kurlan R, Klein C, Ozelius L, Bressman S. Phenotypic spectrum and sex effects in eleven myoclonus-dystonia families with epsilon-sarcoglycan mutations. Mov Disord 2008;23:588-592.

  141. Grünewald A, Djarmati A, Lohmann-Hedrich K, Farrell K, Zeller JA, Allert N, Papengut F, Petersen B, Fung V, Sue CM, O’Sullivan D, Mahant N, Kupsch A, Chuang RS, Wiegers K, Pawlack H, Hagenah J, Ozelius LJ, Stephani U, Schuit R, Lang AE, Volkmann J, Münchau A, Klein C. Myoclonus-dystonia: Significance of large SGCE deletions. Hum Mutat 2008;29:331-332.

  142. Seibler P, Djarmati A, Langpap B, Hagenah J, Schmidt A, Brüggemann N, Siebner H, Jabusch H-C, Altenmüller E, Münchau A, Lohmann K, Klein C. Heteroyzgous nonsense mutation in the PRKRA (DYT16) gene associated with generalized dystonia. Lancet Neurol 2008;7:380-381.

  143. DeStefano AL, Latourelle J, Lew MF, Suchowersky O, Klein C, Golbe LI, Mark MH, Growdon JH, Wooten GF, Watts R, Guttman M, Racette BA, Perlmutter JS, Marlor L, Shill HA, Singer C, Goldwurm S, Pezzoli G, Saint/Hilaire MH, Hendricks AE, Gower A, Williamson S, Nagle MW, Wilk JB, Massood T, Huskey KW, Baker KB, Itin I, Litvan I, Nicholson G, Corbett A, Nance M, Drasby E, Isaacson S, Burn DJ, Dhinnery PF, Pramstaller PP, Al-hinti J, Moller AT, Ostergaard K, Sherman SJ, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. Replication of association between ELAVL4 and Parkinson disease: the GenePD study. Hum Genet 2008;124:95-99.

  144. Reetz K, Lencer R, Steinlechner S, Gaser C, Hagenah J, Büchel C, Petersen D, Kock N, Djarmati A, Siebner HR, Klein C, Binkofski F. Limbic and frontal cortical degeneration is associated with psychiatric symptoms in PINK1 mutation carriers. Biol Psych 2008;64:241-247.

  145. Facheris MF, Maniak S, Scaravilli F, Schüle B, Klein C, Pramstaller PP. Pure akinesia as initial presentation of PSP: a clinicopathological study. Parkinsonism Rel Disord 2008;14:517-519. 

  146. Guettard E, Portnio MF, Lohmann-Hedrich K, Keren B, Rossignol S, Winkler S, El Kamel I, Leu S, Apartis E, Vidailhet M, Klein C, Roze E. Myoclonus-dystonia due to maternal uniparental disomy. Arch Neurol 2008;65:1380-1385.

  147. Brüggemann N, Odin P, Grünewald A, Tadic V, Hagenah J, Seidel G, Lohmann K, Klein C, Djarmati A. De novo alpha-Synuclein duplication as cause of sporadic early onset parkinsonism. Neurology, 2008;71:1294.

  148. Tobin JE, Latourelle JC, Lew MF, Klein C, Suchowersky O, Shill HA, Golbe LI, Mark MH, Growdon JH, Wooten FG, Racette BA, Perlmutter JS, Watts R, Guttman M, Baker KB, Goldwurm S, Pezzoli G, Singer C,
Saint-Hilaire M-H, Hendricks AE, Williamson S, Nagle MW, Wilk JB, Massood T, Laramie JM, DeStefano AL,
Litvan I, Nicholson G, Corbett AJ, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Sherman S, Al-hinti J, Drasby E, Nance M, Moller AT, Ostergaard K, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. Haplotypes and gene expression implicate the MAPT region for
Parkinson disease: The GenePD Study. Neurology 2008;71:28-34.

  149. Muhle H, Neumann A, Lohmann-Hedrich K, Lohnau T, Lu Y, Winkler S, Waltz S, Fischenbeck A, Kramer PL, Klein C, Stephani U. Childhood-onset restless legs syndrome: Clinical and genetic features of 22 families. Mov Disord 2008;23:1113-1121.

  150. Kamm C, Fischer H, Garavaglia B, Kullmann S, Sharma M, Schrader C, Grundmann K, Klein C, Borggräfe I, Lobsien E, Nardocci N, Gasser T. Susceptibility to DYT1 dystonia in European patients is modified by the D216H polymorphism. Neurology 2008;70:2261-2262.

  151. Hagenah JM, Becker B, Brüggemann N, Djarmati A, Lohmann K, Sprenger A, Klein C, Seidel G. Transcranial sonography findings in a large family with homo- and heterozygous PINK1 mutations. J Neurol Neurosurg Psychiatry 2008;79:1071-1074.

  152. McNicoll CF, Latourelle JC, MacDonald PhD ME, Lew MF, Suchowersky O, Klein C, Golbe LI, Mark MH, Growdon JH, Wooten GF, Watts RL, Guttman M, Racette BA, Perlmutter JS, Ahmed A, Shill HA, Singer C, Saint-Hilaire MH, Massood T, Huskey KW, DeStefano AL, Gillis T, Mysore J, Goldwurm S, Pezzoli G, Baker K, Itin I, Litvan I, Nicholson G, Corbett A, Nance M, Drasby E, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Al-hinti J, Moller AT, Ostergaard K, Sherman SJ, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. Huntington CAG repeat size does not modify onset age in familial Parkinson’s disease: The Gene PD Study. Mov Disord 2008;23:1596-1601.

  153. Healy DG, Falchi M, O’Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW, and the Worldwide LRRK2 Consortium. LRRK2-associated Parkinson’s disease: Clinical features based on worldwide experience. Lancet Neurol 2008;7:583-590.

  154. Latourelle JC, Sun M, Lew MF, Suchowersky O, Klein C, Golbe LI, Mark MH, Growdon JH, Wooten GF, Watts RL, Guttman M, Racette BA, Perlmutter JS, Ahmed A, Shill HA, Singer C, Goldwurm S, Pezzoli G, Zini M, Saint-Hilaire MH, Hendricks AE, Williamson S, Nagle MW, Wilk JB, Massood T, Huskey KW, Laramie JM, DeStefano AL, Baker KB, Itin I. The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson’s disease: the GenePD study. BMC Medicine 2008;6:32.

  155. Zschiedrich K, König IR, Brüggemann N, Kock N, Kasten M, Leenders KL, Kostic V, Vieregge P, Ziegler A, Klein C, Lohmann K. MDR1 variants and risk of Parkinson disease: Association with pesticide exposure? J Neurol 2009;256:115-120.

  156. Gierthmühlen J, Lienau F, Maag R, Hagenah JM, Deuschl G, Fritzer E, Klein C, Baron R, Helmchen C. Somatosensory processing in a German family with PINK1 mutations: its potential role in Parkinson disease. J Neurol Neurosurg Psychiatry 2009;80:571-574.

  157. Reetz K, Gaser C, Klein C, Hagenah J, Büchel C, Gottschalk S, Pramstaller PP, Siebner HR, Binkofski F. Structural findings in the basal ganglia in genetically determined and idiopathic Parkinson’s disease. Mov Disord 2009;24:99-103.

  158. Rakovic A, Stiller B, Djarmati A, Flaquer A, Freudenberg J, Toliat M-R, Linnebank M, Kostic V, Lohmann K, Paus S, Nürnberg P, Kubisch C, Klein C, Wüllner U, Ramirez A. Genetic association study of the P-type ATPase ATP13A2 in late onset Parkinson disease. Mov Disord 2009;24:429-433.

  159. van Nuenen BFL, Weiss MW, Bloem BR, Reetz K, v Eimeren T, Lohmann K, Hagenah JM, Pramstaller P, Binkofski F, Klein C, Siebner HR. Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype. Neurology 2009;72:1041-1047.

  160. Brüggemann N, Mitterer M, Lanthaler AJ, Djarmati A, Hagenah J, Wiegers K, Winkler S, Pawlack H, Lohnau T, Pramstaller PP, Klein C, Lohmann K. Frequency of heterozygous Parkin mutations in healthy subjects: Need for careful prospective follow-up examination of mutation carriers. Parkinsonism Rel Disord 2009;15:425-429.

  161. Brüggemann N, Kock N, König IR, Rakovic A, Hagenah J, Schmidt A, Lohmann K, Ziegler A, Jabusch HC, Siebner H, Altenmüller E, Münchau A, Klein C. The D216 variant in the DYT1 gene – a susceptibility factor for dystonia in familial cases. Neurology 2009;72:1441-1443.

  162. Schmidt A, Jabusch H-C, Altenmüller E, Hagenah J, Brüggemann N, Lohmann K, Enders L, Kramer PL, Saunders-Pullman R, Bressman SB, Münchau A, Klein C. Etiology of musician’s dystonia: familial or environmental? Neurology 2009;72:1248-1254.

  163. Paus S, Gadow F, Knapp M, Klein C, Klockgether T, Wüllner U. Motor complications in patients from the German Competence Network on Parkinson’s disease and the DRD3 Ser9Gly polymorphism. Mov Disord 2009;24:1080-1084.

  164. Hertel S, Sprenger A, Klein C, Kömpf D, Helmchen C, Kimmig H. Different saccadic abnormalities in PINK1 mutation carriers and in patients with non-genetic Parkinson’s disease. J Neurol ;256:1192-1194.

  165. Lencer R, Steinlechner S, Stahlberg J, Rehling H, Orth M, Bäumer T, Rumpf H-J, Meyer C, Klein C, Münchau A, Hagenah J. Primary focal dystonia: evidence for distinct neuropsychiatric and personality profiles. J Neurol Neurosurg Psychiatry 2009;80:1176-1179.

  166. Djarmati A, Schneider S, Lohmann K, Winkler S, Pawlack H, Hagenah J, Brüggemann N, Zittel S, Fuchs T, Rakovic A, Schmidt A, Jabusch H-C, Wilcox R, Kostic VS, Siebner H, Altenmüller E, Münchau A, Ozelius L, Klein C. Mutations in the THAP1 (DYT6) gene – a cause of generalized dystonia with prominent spasmodic dysphonia. Lancet Neurol 2009;8:447-452.

  167. Netzer C, Klein C, Kohlhase J, Kubisch C. New challenges for informed consent trhough whole-genome array testing. J Med Genet 2009;46(7):495-6.

  168. Grünewald A, Gegg ME, Taanman J-W, King RH, Kock N, Klein C, Schapira AHV. Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Exp Neurol 2009;219:266-273.

  169. Djarmati A, Hagenah J, Reetz K, Winkler S, Behrens MI, Pawlack H, Lohmann K, Ramirez A, Tadic V, Brüggemann N, Berg D, Siebner HR, Lang AE, Pramstaller PP, Binkofski F, Kostic VS, Volkmann J, Gasser T, Klein C. ATP13A2 variants in early-onset Parkinson’s disease patients and controls. Mov Disord 2009;24:2104-2111.

  170. Van Nuenen BFL, van Eimeren T, van der Vegt JPM, Buhmann C, Klein C, Bloem BR, Siebner HR. Mapping preclinical compensation in Parkinson’s disease: am imaging genomics approach. Mov Disord 2009;24 Suppl 2:S703-S710.

  171. Simon-Sanchez J, Schulte C, Bras JM, Sharma M, Gibbs R, Berg D, Paisan-Ruiz C. Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Foote KD, Fernandez HH, Schreiber S, Arepalli S, Zonozi R, Gwinn K, Lopez G, Chanock SJ, Schatzkin A, Park Z, Hollenbeck A, Gao J, Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T. Genome-wide assocation study reveals genetic risk underlying Parkinson’s disease. Nature Genet 2009;41:1308-1312.

  172. Reetz K, Tadic V, Kasten M, Brüggemann N, Schmidt A, Hagenah J, Pramstaller PP, Ramirez A, Behrens MI, Siebner HR, Klein C, Binkofski F. Structural imaging in the presymptomatic stage of genetically determined parkinsonism Neurobiol Dis 2010;39:402-408.

  173. Pichler I, Marroni F, Lohmann K, De Grandi A, Klein C, Hicks AA, Pramstaller PP. Parkin gene modifies the effect of RLS4 on the age at onset of restless legs syndrome (RLS). Am J Med Genet B Neuropsychiatr Genet 2010;153B:350-355.

  174. Steinlechner S, Klein C, Moser A, Lencer R, Hagenah J. Botulinum toxin B as an effective and safe treatment for neuroleptic-induced sialorrhea. Psychopharmacol 2010;207:593-597.

  175. Walter M, Bonin M, Saunders-Pullman R, Valente EM, Loi M, Gambarin M, Raymond D, Tinazzi M, Kamm C, Glöckle N, Poths S, Gasser T, Bressman SB, Klein C, Ozelius LJ, Riess O, Grundmann K. Expression profiling in peripheral blood reveals signature for penetrance in DYT1 dystonia. Neurobiol Disease 2010;38:192-200.

  176. Eggers C, Schmidt A, Hagenah J, Brüggemann N, Klein JC, Tadic V, Kertelge L, Binkofski F, Siebner H, Neumaier B, Fink GR, Hilder R, Klein C. Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit. Neurology 2010;51:28-32.

  177. Verleger R, Hagenah J, Weiss M, Ewers T, Heberlein I, Pramstaller P, Siebner HR, Klein C. Responsiveness to distracting stimuli, though increased in Parkinson’s disease, is decreased in asymptomatic PINK1 and Parkin mutation carriers. Neuropsychologia 2010;74(22):1798-805.

  178. Svetel M, Ozelius LJ, Buckley A, Lohmann K, Brajkovic L, Klein C, Kostic VS. Rapid-onset dystonia-parkinsonism: case report. J Neurol 2010;257:472-474.

  179. Gierthmühlen J, Schumacher S, Deuschl G, Fritzer E, Klein C, Baron R, Helmchen C. Somatosensory function in asymptomatic parkin mutation carriers. Eur J Neurol 2010;173:513-517.

  180. Weissbach A, Djarmati A, Klein C, Dragasevic N, Zühlke C, Rakovic A, Guzvic M, Butz E, Tönnies H, Siebert R, Petrovic I, Svetel M, Kostic VS, Lohmann K. Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15. Mov Disord 2010;25:1577-1582.

  181. Marras C, Klein C, Lang AE, Wakutani Y, Moreno D, Sato C, Yip E, Munhoz R, Lohmann K, Djarmati A, Bi A, Rogaeva E. LRRK2 and Parkin muations in a family with parkinsonism – lack of genotype-phenotype correlation. Neurobiol Aging 2010;31:721-722.

  182. Behrens MI, Brüggemann N, Chana P, Venegas P, Kägi M, Parrao T, Orellana P, Garrido C, Rojas CV Hauke J, Hahnen E, Gonzalez R, Seleme N, Fernandez V, Schmidt A, Binkofski F, Kömpf D, Kubisch C, Hagenah J, Klein C, Ramirez A. Clinical spectrum of Kufor Rakeb Syndrome in the Chilean kindered with ATP13A2 mutations. Mov Disord 2010;25:1929-1937.

  183. Spuler S, Krug H, Klein C, Medialdea IC, Jakob W, Ebersbach G, Gruber D, Hoffmann K-T, Trottenberg T, Kupsch A. Myopathy causing camptocormia in idiopathic Parkinson’s disease: a multidisciplinary approach. Mov Disord 2010;25:552-559.

  184. Kasten M, Weichert C, Lohmann K, Klein C. Clinical and demographic characteristics of PINK1 mutation carriers – A meta-analysis. Mov Disord 2010;25:952-954.

  185. Paus S, Gadow F, Kaut O, Knapp M, Klein C, Klockgether T, Wüllner U. Tremor in Parkinson’s disease is not associated to the DRD3 Ser9Gly polymorphism. Parkinsonism Rel Disord 2010;16:381-383.

  186. Hagenah J, König IR, Sperner J, Wessel L, Seidel G, Condefer K, Saunders-Pullman R, Klein C, Brüggemann N. Life-long increase of substantia nigra hyperechogenicity. Neuroimage 2010;51:28-32.

  187. Machner B, Klein C, Sprenger A, Baumbach P, Pramstaller P, Helmchen C, Heide W. Eye movement disorders are different in Parkin-linked and idiopathic early-onset Parkinson’s disease. Neurology 2010;75:125-158.

  188. van Eimeren T, Binkofski F, Buhmann C, Hagenah J, Strafella A, Pramstaller PP, Siebner HR, Klein C. Imaging movement-related activity in medicated Parkin-associated and sporadic Parkinson’s disease. Parkinsonism Rel Disord 2010;16:384-387.

  189. Gruber D, Kühn AA, Schoenecker T, Kivi A, Trottenberg T, Hoffmann KT, Gharabaghi A, Kopp UA, Schneider GH, Klein C, Asmus F, Kupsch A. Pallidal and thalamic deep brain stimulation in myoclonus-dystonia. Mov Disord 2010;2511:1733-1743.

  190. Rakovic A, Grünewald A, Seibler P, Ramirez A, Kock N, Orolicki S, Lohmann K, Klein C. Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Hum Mol Genet 2010;19:3124-3137.

  191. Grünewald A, Voges L, Rakovic A, Kasten M, Vandebona H, Hemmelmann C, Lohmann K, Orolicki S, Ramirez A, Schapira AHV, Pramstaller PP, Sue CM, Klein C. Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS One 2010;5:e12962.

  192. Brüggemann N, Hagenah J, Reetz K, Schmidt A, Kasten M, Buchmann I, Eckerle S, Bähre M, Münchau A, Djarmati A, van der Vegt J, Siebner H, Binkofski F, Ramirez A, Behrens MI, Klein C. Recessively inherited parkinsonism: effect of ATP13A2 mutations on the clinical and neuroimaging phenotype. Arch Neurol 2010;67:1357-1363.

  193. Klebe S, Their S, Lorenz D, Nothnagel M, Schreiber S, Klein C, Hagenah J, Kasten M, Gasser T, Deuschl G, Kuhlenbäumer G. LINGO1 is not associated with Parkinson’s disease in German patients. Am J Med Genet B Neuropsychiatr Genet 2010;153B:1173-1178.

  194. Saunders-Pullman R, Hagenah J, Dhawan V, Stanley K, Pastores g, Sathe S, Tagliati M, Condefer K, Palmese C, Brüggemann N, Klein C, Roe A, Kornreich R, Ozelius L, Bressman S. Gaucher disease ascertained through a Parkinson’s center: Imaging and clinical characterization. Mov Disord 2010;25:1364-1372.

  195. Kertelge L, Brüggemann N, Schmidt A, Tadic V, Wisse C, Dankert S, Drude L, van der Vegt J, Siebner H, Pawlack H, Pramstaller PP, Behrens MI, Ramirez A, Reichel D, Buhmann C, Hagenah J, Klein C, Lohmann K, Kasten M. Impaired sense of smell and color discrimination in mongenic and idiopathic Parkinson disease. Mov Disord 2010;25:2665-2669.

  196. Kasten M, Brüggemann N, Schmidt A, Klein C. Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology 2010;75:478.

  197. Brüggemann N, Schneider SA, Sander T, Klein C, Hagenah J. Distinct basal ganglia hyperechogenicity in idiopathic basal ganglia calcification. Mov Disord 2010;25:2661-2664.

  198. Reetz K, Lencer R, Hagenah JM, Gaser C, Tadic V, Walter U, Wolters A, Steinlechner S, Zühlke C, Brockmann K, Klein C, Rolfs A, Binkofski F. Structural changes associated with progression of motor deficits in spinocerebellar ataxia 17. Cerebellum 2010;9:210-217.

  199. Saunders-Pullman R, Stanley K, Brüggemann N, Rayomend D, San Luciano M, Wang C, Klein C, Lubarr N, Ozelius L, Bressman SB, Hagenah J. Substantia nigra hyperechogenicity in DYT6 dystonia: A pilot study. Parkinsonism Rel Disord 2010;16:420-422.

  200. Stanley K, Hagenah J, Brüggemann N, Reety K, Severt L, Klein C, Yu Q, Derby C, Pullman S, Saunders-Pullman R. Digitized spiral analysis is a promising early motor marker for Parkinson disease. Parkinsonism Rel Disord 2010;16:233-234.

  201. Zittel S, Moll CKE, Brüggemann N, Tadic V, Hamel W, Kasten M, Lohmann K, Lohnau T, Winkler S, Gerloff C, Schönweiler R, Hagenah J, Klein C, Münchau A, Schneider SA. Clinical, neuroimaging and electrophysiological assessment of three DYT6 dystonia families. Mov Disord 2010;25:2405-2412.

  202. Machner B, Sprenger A, Behrens MI, Ramirez A, Brüggemann N, Klein C, Helmchen C. Eye movement disorders in ATP13A2 mutation carriers (PARK9). Mov Disord 2010;25:2687-2689.

  203. Kaiser FJ, Osmanovic A, Rakovic A, Erogullari A, Uflacker N, Braunholz D, Lohnau T, Orolicki S, Albrecht M, Gillessen-Kaesbach G, Klein C (gleichberechtigter Letztautor), Lohmann K. The dystonia gene DYT1 is repressed by the transcription factor THAP1 (DYT6). Ann Neurol 2010;68:554-559.

  204. Opladen T, Hoffmann GF, Hörster F, Hinz AB, Neidhardt K, Klein C, Wolf NI. Clinical and biochemical characterization of patients with early infantile onset of autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia. Mov Disord 2010;26:157-161.

  205. Facheris MF, Hicks AA, Minelli C, Hagenah JM, Kostic V, Campbell S, Hayward C, Volpato CB, Pattaro C, Vitart V, wright A, Campbell H, Klein C, Pramstaller P. Variation in the uric acid transporter gene SLC2A9 wand its association with AAO of Parkinson’s disease. J Mol Neurosci 2010;43:246-250.

  206. Kasten M, Tadic V, Klein C. Hemoglobin levels in idiopathic and genetic Parkinson disease. Neurology 2010;74:1655.

  207. Kagi G, Klein C, Wood NW, Schneider SA, Pramstaller PP, Tadic V, Quinn NP, van de Warrenburg BP, Bhatia KP. Non-motor symptoms in parkin gene-related parkinsonism. Mov Disord 2010;25:1279-1284.

  208. Krüger R, Sharma M, Riess O, Gasser T, van Broeckhoven C, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska/Myga B, Klein C, Lesage S, Lin J-J, Lynch T, Mellick GD, de Nigris F, Opala G, Prigione A, Quattrone A, Ross OA, Satake W, Silburn PA, Tan EK, Theuns J, Toda T, Tomiyama H, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM. A large-scale genetic association study to evaluate the contributaion of Omi/HtrA2 (PARK13) to Parkinson’s disease. Neurobiol Aging 2011;32:548.e9-18.

  209. Ramirez A, Ziegler A, Winkler S, Kottwitz J, Giesen R, Diaz-Grez F, Miranda M, Venegas P, Godoy OT, Avello R, Behrens MI, Klein C, Segura-Aguilar, Lohmann K. Association of Parkinson disease to PARK16 in a Chilean sample. Parkinsonism Relat Disord 2011;17:70-71.

  210. Reetz K, Kleiman A, Klein C, Lencer R, Zühlke C, Brockmann K, Rolfs A, Binkofski F. CAG repeats determine brain atrophy in spinocerebellar ataxia 17: A VBM study. PLoS One 2011;6:e15125.

  211. Schmidt A, Jabusch H-C, Altenmüller E, Enders L, Saunders-Pullman R, Bressman SB, Münchau A, Klein C, Hagenah J. Phenotypic spectrum of musician’s dystonia: A task-specific disorder? Mov Disord 2011;25:546-549.

  212. Schneider SA, Ramirez A, Shafiee K, Kaiser FJ, Erogullari A, Brüggemann N, Winkler S, Bahman I, Osmanovic A, Shafa MA, Bhatia KP, Najmabadi H, Klein C, Lohmann K. Homozygous THAP1 mutations as cause of early-onset generalized dystonia. Mov Disord 2011;26:858-861.

  213. Elbaz A, Ross OA, Ioannidis JPA, Soto-Ortolaza, Moisan F, Aasly J, Annesi G, Bozi M, Brighina L, Chartier-Harlin M-C, Destée A, Ferrarese C, Ferraris A, Gibson M, Suzana Gispert S, Hadjigeorgiou GM, Jasinska-Myga B, Klein C, Krüger R, Lambert J-C, Lohmann K, van de Loo S, Loriot A-M, Lynch T, MD, Mellick GD, Mutez E, Nilsson C, Opala G, Puschmann A, Quattrone A, Sharma M, Silburn PA, Stefanis L, MD, PhD, Uitti RJ, Valente EM, Vilariño-Güell C, Wirdefeldt, Wszolek ZK, Xiromerisiou G, Maraganore DM, Farrer MJ on behalf of the Genetic Epidemiology Of Parkinson’s Disease (GEO-PD) consortium. Independent and joint effects of the MAPT and SNCA genes in Parkinson’s disease. Ann Neurol 2011;69:778-792.

  214. Brüggemann N, Würfel J, Petersen D, Klein C, Hagenah J, Schneider SA. Idiopathic NBIA – clinical spectrum and transcranial sonography findings. Eur J Neurol 2011;18:e58-9.

  215. Enders L, Spector JT, Altenmüller E, Schmidt A, Klein C, Jabusch H-C. Musician’s dystonia and comorbid anxiety: two sides of one coin? Mov Disord 2011;26:539-542.

  216. Brüggemann N, Hagenah J, Stanley K, Klein C, Wang C, Raymond D, Ozelius L, Bressman S, Saunders-Pullman R. Substantia nigra hyperechogenicity with LRRK2 G2010S mutations. Mov Disord 2011;26:885-888.

  217. Fong CY, Rolfs A, Schwarzbraun T, Klein C, O’Callaghan FJK. Juvenile parkinsonism associated with heterozygous frameshift ATP13A2 gene mutation. Eur J Ped Neurol 2011;15:271-275.

  218. Rakovic A, Grünewald A, Kottwitz J, Brüggemann N, Pramstaller PP, Lohmann K, Klein C. Mutations in PINK1 and Parkin impair ubiquitylation of Mitofusins in human fibroblasts. PLoS One 2011;6:e16746.

  219. Seibler P, Graziotto J, Heong H, Simunovic F, Klein C, Krainc D. Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 iPS cells. J Neurosci 2011;31:5970-5976.

  220. Kasten M, Brüggemann N, König I, Doerry K, Steinlechner S, Wenzel L, Lohmann K, Klein C, Lencer R. Risk for antipsychotic-induced extrapyramidal symptoms: influence of family history and genetic susceptibility. Psychopharmacology (Berl) 2011;214:729-736.

  221. Hagenah J, König IR, Kötter C, Seidel K, Klein C, Brüggemann N. Basal ganglia hyperechogenicity does not distinguish between patients with primary dystonia and healthy individuals. J Neurol 2011;258:590-595.

  222. Steinlechner S, Brüggemann N, Sobottka V, Benthien A, Behn B, Klein C, Schmid G, Lencer R. Restless legs syndrome as a possible predictor for psychiatric disorders in parents of children with ADHD. Eur Arch Psychiatry Clin Neurosci 2011;261:285-291.

  223. Rakovic A, Grünewald A, Voges L, Hofmann S, Orolicki S, Lohmann K, Klein C. PINK1-interacting proteins: Proteomic analysis of overexpressed PINK1. Special Issue: Mitochondrial Dysfunction in Parkinson’s Disease. Parkinson’s Disease 2011;2011:153979.

  224. Marras C, Schuele B, Munhoz RP, Rogaeva EA, Langston JW, Kasten M, Meaney C, Klein C, Wadia PM, Lim S-Y, Chuang R S-I, Zadikoff C, Steeves T, Prakash KM, de Bie RMA, Adeli G, Thomsen T, Johansen K, Teive H, Asante A, Reginold W, Lang AE. Phenotype in parkinsonian and non-parkinsonian LRRK2 mutation carriers. Neurology 2011;77:325-333.

  225. Schiebler S, Schmidt A, Zittel S, Bäumer T, Gerloff C, Klein C, Münchau A. Arm tremor in cervical dystonia – is it a manifestation of dystonia or essential tremor? Mov Disord 2011;26:1789-1792.

  226. Kamm C, Uflacker N, Asmus F, Schrader C, Wolters A, Wittstock M, Pahnke J, Gasser T, Volkmann J, Münchau A, Hagenah J, Benecke R, Klein C, Lohmann K. No evidence for THAP1/DYT6 mutations as a potential disease modifier in DYT1 dystonia. Mov Disord 2011;26:2136-2137.

  227. Osmanovic A, Dendorfer A, Erogullari A, Uflacker N, Braunholz D, Rakovic A, Vierke G, Gil-Rodriguez MC, Münchau A, Albrecht M, Brüggemann N, Gillessen-Kaesbach G., Klein C, Lohmann K, Kaiser FJ. Truncating mutations in THAP1 define the nuclear localization signal. Mov Disord 2011;26:1565-1567.

  228. Sharma M, Maraganore DM, Ioannidis JP, Riess O, Aasly JO, Annesi G, Abahuni N, Bentivoglio AR, Brice A, Broeckhoven CV, Chartier-Harlin M-C, Destree A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Gispert S, Hattori N, Jasinska-Myga B, Klein C, Lesage S, Lynch T, Lichtner P, Lambert J-C, Lang AE, Mellick GD, Nigris FD, Opala G, Quattrone A, Riva C, Rogaeva E, Ross OA, Satake W, Silburn PA, Theuns J, Toda T, Tomiyama H, Uitti RJ, Wirdefeldt K, Wszolek Z, Gasser T, Krüger R. Role of sepiapterin reductase gene at the PARK3 locus in Parkinson disease. Neurobiol Aging 2011;32:2108e1-5.

  229. Arif B, Anne G, Amara F, Ramirez A, Arif A, Brüggemann N, Würfel J, Rolfs A, Lohmann K, Akbar M, Klein C, Naz S. An unusual neurological syndrome of crawling gait, dystonia, pyramidal signs and limited speech. Mov Disord 2011;26:2279-2283.

  230. Ross O, Soto-Ortolaza AI, Heckman MG, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, van Broeckhoven C, Carr J, Chartier-Harlin M-C, Dardiotis E, Dickson DW, Diehl NN, Elbaz A, Ferrarese C, Ferraris A, Fiske B, Fibson JM, Gibson R, Hadjigeorgiou GM, Hattori N, Ioannidis JPA, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lesage S, Lin C-H, Lynch T, Maraganore DM, Mellick GD, Mutez E, Nilsson C, Opala G, Park SS, Puschmann A, Quattrone A, Sharma M, Silburg PA, Sohn YH, Stefanis L, Tadic V, Theuns J, Tomiyama H, Uitti RJ, Valente EM, van de Loo S, Vassilatis DK, Vilarino-Guell C, White LR, Wirdefelt K, Wszolek ZK, Wu R-M, Farrer MJ. LRRK2 exonic variants and susceptibility to Parkinson’s disease. Lancet Neurol 2011;10(10):898-908.

  231. Abramov A, Gegg M, Hardy J, Wood NW, Klein C, Schapira AH. Bioenergetic consequences of PINK1 mutations in Parkinson disease. PLoS One 2011;6:e25622.

  232. Lopez-Laso E, Sanchez-Raya A, Moriana-Elvira JA, Martinez-Güal, Camino-Leon R, Mateos-Gonzalez ME, Perez-Navero JL, Sepulveda JJO, Ormazabal A, Opladen T, Klein C, Lao-Villadoniga JI, Artuch R. Neuropsychological assessment in autosomal dominant Segawa syndrome due to guanosine triphosphate cyclohydrolase I deficiency. J Neurol 2011;258:2155-2162.

  233. Klein C, Chuang R, Marras C, Lang AE. The curious case of phenocopies in families with genetic Parkinson’s disease. Mov Disord 2011;26:1793-1802.

  234. Djarmati A, Brüggemann N, Espay AJ, Bhatia KP, Klein C. Genetic heterogeneity of congenital mirror movements. Neurology 2011;77:1580.

  235. Heinitz S, Klein C, Djarmati A. The pS77N PARL mutation is not a frequent cause of early-onset Parkinson’s disease. Mov Disord 2011,26:2441-2442.

  236. Zittel S, Bäumer T, Brüggemann N, Gerloff C, Klein C, Münchau A. Paroxysmal cervical myoclonus. Mov Disord 2011;26:2445-2446.

  237. van Es M, Schelhaas HJ, van Vught PWJ, Ticozzi N, Andersen PM, Groen EJN, Schulte C, Blauw HM, Koppers M, Diekstra FP, Fumoto K, LeClerc AL, Keagle P, Bloem BR, Scheffer H, van Nuenen BFL, van Blitterswijk M, van Rheenen W, Wills A-M, Lowe PP, Hu G-F, Yu W, Kishikawa H, Wu D, Folkerth RD, Mariani C, Goldwurm S, Pezzoli G, van Damme P, Lemmens R, Dahlberg C, Birve A, Fernandez-Santiago R, Waibel S, Klein C, Weber M, van der Kooi AJ, de Visser M, Verbaan D, van Hilten JJ, Heutink P, Hennekam EAM, Cuppen E, Berg D, Bronw Jr RH, Silani V, Gasser T, Ludolph AC, Robberecht W, Ophoff RA, Veldink JH, Pasterkamp RJ, de Bakker PIW, Landers JE, van de Warrenburg BP, van den Berg LH. Angiogenin mutations in Parkinson’s disease and amyotrophic lateral sclerosis. Ann Neurol 2011;70:964-973.

  238. Klein C. The Wilson films from Queen Square – Huntington’s chorea – Case 9. Mov Disord 2011;26:2464-2466.

  239. Palada V, Terzic J, Mazzulli J, Bwala G, Hagenah J, Peterlin B, Hung AY, Klein C, Krainc D. Histamine N-methyltransferase Thr105Ile Polymorphism is associated with Parkinson's disease. Neurobiol Aging 2012; 33(4):836.e1-3.

  240. Lohmann K, Uflacker N, Erogullari A, Lohnau T, Winkler S, Dendorfer A, Schneider SA, Osmanovic A, Svetel M, Ferbert A, Zittel S, Kühn A, Schmidt A, Altenmüller E, Münchau A, Kamm C, Wittstock M, Kupsch A, Moro E, Volkmann J, Kostic V, Kaiser FJ, Klein C, Brüggemann N. Identification and functional analysis of novel THAP1 mutations. Eur J Hum Genet 2012; 20(2):171-5.

  241. Brüggemann N, Külper W, Hagenah J, Bauer P, Pattaro C, Tadic V, Lohnau T, Winkler S, Tonnies H, Sprenger A, Pramstaller P, Rolfs A, Siebert R, Riess O, Vieregge P, Lohmann K, Klein C. Autosomal dominant Parkinson’s disease in a large German pedigree. Acta Neurol Scand 2012; 126(2):129-37.

  242. Zittel S, Kroeger J, van der Vegt JPM, Siebner HR, Brüggemann N, Ramirez A, Behrens MI, Gerloff C, Bäumer T, Klein C, Münchau A. Motor pathway exitability in ATP13A2 mutation carriers: a transcranial magnetic stimulation study. Park Rel Disord 2012; 18(5):590-4.

  243. Kumar KR, Weissbach A, Heldmann M, Kasten M, Tunc S, Sue CM, Svetel M, Kostic VS, Segura-Aguilar J, Ramirez A, Simon DK, Vieregge P, Münte TF, Hagenah J, Klein C, Lohmann K. Screening of an international Parkinson’s disease cohort for the recently described D620N mutation in the VPS35 gene. Arch Neurol, 2012; 16:1-5.

  244. Brüggemann N, Spiegler J, Hellenbroich Y, Opladen T, Schneider SA, Stephani U, Boor R, Gillessen-Kaesbach G, Sperner J, Klein C. Beneficial prenatal levodopa therapy in autosomal recessive GTP cyclohydrolase I deficiency. Arch Neurol, 2012; 69(8):1071-5.

  245. Marras C, Lohmann K, Lang AE, Klein C. Fixing the broken system of genetic locus symbols: Parkinsonism and dystonia as examples. Neurology, 2012; 78(13):1016-24.

  246. Anders S, Sack B, Pohl A, Münte T, Pramstaller P, Klein C, Binkofski F. Evidence for compensatory ventrolateral premotor activity during affective face processing in subclinical carriers of a single mutant Parkin allele. Brain, 2012; 135(Pt 4):1128-40.

  247. Depienne C, Bouteiller D, Meneret A, Billot S, Groppa S, Klebe S, Brueggemann N, Bhatia K, Cincotta M, Brochard V, Flamand-Roze C, Carpentier W, Meunier S, Marie Y, Gaussen M, Stevanin G, Wehrle R, Charbonnier-Beaupel F, Corvol JC, Vidailhet M, Klein C, Dusart I, Brice A, Roze E. RAD51 haploinsufficiency causes congenital mirror movements in humans. Am J Hum Genet, 2012; 90(2):301-7.

  248. Schmidt A, Altenmüller E, Jabusch H-C, Lee A, Wiegers K, Klein C, Lohmann K. The GAG deletion in Tor1A (DYT1) is a rare cause of complex musician’s dystonia. Parkinsonism Rel Disord, 2012; 18(5):690-1.

  249. Schmidt A, Kumar KR, Redyk K, Grünewald A, Leben M, Münchau A, Sue CM, Hagenah J, Hartmann H, Lohmann K, Christen H-J, Klein C. Two faces of the same coin: Benign familial infantile seizures and paroxysmal kinesigenic dyskinesia caused by PRRT2 mutations. Arch Neurol, 2012, 13(4):228-32.

  250. Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide B-M M, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hil-Burns EM, Klein C, Latourelle J, Maraganore DM, Martin E, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Kefansson K, Singleton AB, Toda T, Tung JY, Vance J, Wood N, Zabetian, 23and Me Inc., The Genetic Epidemiology of Parkinson’s Disease (GEO-PD) Consortium, The International Parkinson’s Disease Genomics Consortium (IPDGC), The Parkinson’s Dissease GWAS Consortium, The WEllcome Trust Case Control Consrotium 2 (WTCCC2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JPA, Bertram L. Systematic meta-analysis of candidate gene and genome-wide association studies in Parkinson’s disease: Comprehensive research synopsis and systematic meta-analyses in Parkinson’s disease genetics: The PDGene Database. PLoS Genet, 2012, 8(3):e1002548.

  251. Appenzeller S, Their S, Papengut F, Klein C, Hagenah J, Kasten M, Berg D, Srulijes K, Gasser T, Schreiber S, Deuschl G, Kuhlenbäumer. No association between NOD2 variants and Parkinson disease. Mov Disord, 2012; 27(9):1191-2.

  252. Grünewald A, Arns B, Rakovic A, Münchau A, Ramirez A, Sue CM, Klein C. Mutations in ATP13A2 impact on mitochondrial function and morphology in human fibroblasts. Neurobiol Aging, 2012; 33(8):1843.e1-7.

  253. Dehay B, Ramirez A, Martinez-Vicente M, Perier C, Canron MH, Doudnikoff E, Vital A, Vila M, Klein C, Bezard E. Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration. Proc Natl Acad Sci U S A 2012;109:9611-9616.

  254. Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O. Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells Patients with familial Parkinson’s disease. Sci Transl Med 2012;4:141ra90.

  255. Wortmann SB, Vaz FM, Gardeitschik T, Vissers LELM, Renkema GH, Schuurs-Hoeijmakers JHM, Kulik W, Lammens M, Christin C, Kluijtmans LAJ, Rodenburg RJ, Nijmans LGJ, Grünewald A, Klein C, Gerhold JM, Kozicz T, van Hasselt PM, Harakalova M, Kloosterman W, Baric I, Pronicka E, Ucar SK, Naess K, Singhal K, Rumina Z, Gilissen C, van Bokhoven H, Veltman JA, Smeitink JAM, Lefeber DJ, Spelbrink JN, Wevers RA, Morava E, de Brouwer APM. Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness. Nature Genetics, 44:797-802.

  256. Groen JL, Kallen MC, van de Warrenburg BP, Speelman JD, van Hilten JJ, Aramideh M, Boon AJ, Klein C, Koelman JH, Langeveld TP, Baas F, Tijssen MA. Phenotypes and genetic architecture of focal primary torsion dystonia. J Neurol Neurosurg Psychiatry 2012; epub ahead of print.

  257. Schmitt I, Wüllner U, van Rooyen JP, Khazneh H, Becker J, Volk A, Kubisch C, Becker T, Kostic VS, Klein C, Ramirez A. Variants in the 3'UTR of SNCA do not affect miRNA-433 binding and alpha-synuclein expression. Eur J Hum Genet 2012; epub ahead of print.

  258. Göbel A, Macklin EA, Winkler S, Betensky RA, Klein C, Lohmann K, Simon DK. Genetic risk factors in Parkinson's disease: single gene effects and interactions of genotypes. J Neurol 2012, epub ahead of print.

  259. Tadic V, Kasten M, Brüggemann B, Stiller S, Hagenah J, Klein C. Dopa-responsive dystonia revisited: Diagnostic delay, residual signs, and non-motor signs. Arch Neurol, in press.

  260. Richter J, Appenzeller S, Ammerpohl O, Deuschl G, Paschen S, Brüggemann N, Klein C, Kuhlenbäumer G. No evidence for differential methylation of α-synuclein in leukocyte DNA of Parkinson's disease patients. Mov Disord 2012;27(4):590-591.

  261. Dehay B, Martinez-Vicente M, Ramirez A, Perier C, Klein C, Vila M, Bezard E. Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove. Autophagy, 2012:8:1389-1391.

  262. Kumar K, Ramirez A, Gobel A, Kresojevic N, Svetel M, Lohmann K, Sue C, Rolfs A, Mazzulli J, Alcalay R, Krainc D, Klein C, Kostic V, Grunewald A. Glucocerebrosidase mutations in a Serbian Parkinson’s disease population. Eur J Neurol, in press.

  263. Schneider SA, Drude L, Kasten M, Klein C, Hagenah J. A study of subtle motor signs in early Parkinson’s disease. Mov Disord, in press.

  264. Weissbach A, Siegesmund K, Brüggemann N, Schmidt A, Kasten M, Pichler I, Muhle H, Lohmann E, Lohnau T, Schwinger E, Hagenah J, Stephani U, Pramstaller PP, Klein C, Lohmann K. Exome sequencing in a family with restless legs syndrome. Mov Disord, in press.

Reviews/Book Chapters/Viewpoints
  1. Klein C, Gehl H-B, Hagenah J, Trillenberg P, Vieregge P. Kongenitaler muskulärer Tortikollis im Erwachsenenalter. Nervenheilkunde 1998;17:355-358.

  2. Klein C, Vieregge P. Nichtepileptische paroxysmale Bewegungsstörungen - Eine Übersicht. Nervenarzt 1998;69:647-659.

  3. Klein C, Breakefield XO, Ozelius L. Genetics of primary dystonia. In: Inherited neurologic disorders. Fink JK (Ed.) Semin Neurol 1999;3:271-280.

  4. Klein C, Kann M, Kis B, Pramstaller PP, Breakefield XO, Ozelius LJ, Vieregge P. Genetik der Dystonien. Nervenarzt 2000;71:431-441.

  5. Klein C, Vieregge P. Genetik der Dystonien. Neurodate 2001;15:18-22.

  6. Klein C. Genetische Aspekte des Parkinson-Syndroms. Schweiz Rundsch Med Prax 2001;90:1015-1023.

  7. Klein C, Ozelius L. Dystonia: Clinical features, genetics, and treatment. Curr Opin Neurol 2002;15:491-497.

  8. Klein C. Pedigrees and modes of inheritance. In: Biology for Students. Robinson R (Ed.) Biology. New York: MacMillan Reference USA, 2002, pp186-189.

  9. Klein C. Myoclonus and myoclonus-dystonias. In: Genetics of Movement Disorders. Pulst SM (Ed.), Academic Press 2003, pp451-471.

  10. Klein C. Genetik der Dystonien. Fortschr Neurol Psychiatr 2004;72:220-234.

  11. Klein C. Movement Disorders: Classifications. J Inherit Metab Dis 2005;28:425-439.

  12. Hagenah J, Kahl KG, Steinlechner S, Lencer R, Klein C. Die Behandlung der Sialorrhoe mit Botulinum-Toxin: Eine Übersicht. Nervenarzt 2005;76:418-425.

  13. Klein C. Implications of genetics on diagnosis and care of Parkinson disease patients. Arch Neurol 2006;63:328-334.

  14. Klein C, Schlossmacher MG. Parkinson disease genetics: Implications for neurological care. Nature Clin Pract Neurol 2006;2:136-146.

  15. Zadikoff C, Lang AE, Klein C. The “essentials” of essential palatal tremor: A reappraisal of the nosology. Brain 2006;129:832-840.

  16. Klein C, Ozelius L, Breakefield XO. Genetic evaluation in primary dystonia. In: Handbook of Dystonia. Stacy M (Ed.), Taylor & Francis Group 2007, pp 21-44.

  17. Lohmann-Hedrich K, Brüggemann N, Hagenah J, Klein C. Das Parkinson-Syndrom und seine genetischen Ursachen – eine Standortbestimmung. Akt Neurol 2007;34:151-161.

  18. Klein C, Lohmann-Hedrich K. Genetic findings in Parkinson’s disease. Curr Opin Neurol 2007;20:453-464.

  19. Klein C, Schlossmacher MG. Parkinson disease, ten years after its genetic revolution: Multiple clues to a complex disorder. Neurology 2007;69:2093-2104.

  20. Winkelmann J, Polo O, Provini F, Nevsimalova S, Kemlink D, Sonka K, Hogl B, Poewe W, Stiasny-Kolster K, Oertel W, de Weerd A, Strambi LF, Zucconi M, Pramstaller PP, Arnulf I, Trenkwalder C, Klein C, Hadjigeorgiou GM, Happe S, Rye D, Montagna P. Genetics of restless legs syndrome (RLS): State-of-the-art and future directions. Mov Disord 2007;22(Suppl.18):S449-S458.

  21. Trenkwalder C, Kohnen R, Allen RP, Benes H, Ferini-Strambi L, Garcia-Borreguero D, Hadjigeorgiou GM, Happe S, Hogl B, Hornyak M, Klein C, Nass A, Montagna P, Oertel WH, O'keeffe S, Paulus W, Poewe W, Provini F, Pramstaller PP, Sieminski M, Sonka K, Stiasny-Kolster K, de Weerd A, Wetter TC, Winkelmann J, Zucconi M. Clinical trials in restless legs syndrome-Recommendations of the European RLS Study Group (EURLSSG). Mov Disord 2007;22(Suppl.18):S495-S504.

  22. Klein C. Dystonia: Myoclonus-dystonia, The New Encyclopedia of Neuroscience, Squire L et al. (Ed.), Elsevier 2007.

  23. Kock N, Lohmann K, Klein C. Dystonia, primary. In: Encyclopedia of Molecular Mechanisms of Disease. Lang F (Ed.), Springer, 2008:558-560.

  24. Lohmann K und Klein C. Genetics of Parkinson disease. Continuum: Lifelong Learning in Neurology. 2008;14:90-113.

  25. Schmidt A, Jabusch HC, Altenmüller E, Hagenah J, Saunders-Pullman R, Bressman S, Münchau A, Klein C. Is musician’s dystonia an inherited condition? In: Williamon A, Pretty S, Buck R, eds. Proceedings of the International Symposium on Performance Science 2009. Utrecht: European Association of Conservatoires (AEC) 2009:375-380.

  26. Klein C, Schneider SA, Lang AE. Hereditary parkinsonism: Parkinson disease look-alikes – an algorithm for clinicians to ‘PARK’ genes and beyond. Mov Disord 2009;24:2042-2058.

  27. van der Vegt JPM, van Nuenen BFL, Bloem BR, Klein C, Siebner HR. Imaging the impact of genes on Parkinson’s disease. Neuroscience, 2009;164:191-204.

  28. Kasten M, Kertelge L, Brüggemann N, van der Vegt J, Schmidt A, Tadic V, Buhmann C, Steinlechner S, Behrens MI, Ramirez A, Binkofski F, Siebner H, Raspe H, Hagenah J, Lencer R, Klein C. Non-motor symptoms in genetic Parkinson disease. Arch Neurol 2010;67:670-676.

  29. Brüggemann N, Vegt J, Klein C, Siebner HR. Neurobildgebung genetischer Aspekte der Parkinson-Krankheit. Nervenarzt 2010;81:1196-1203.

  30. Schmidt A, Klein C. The role of genes in causing dystonia. Eur J Neurol 2010;17:65-70.

  31. Brüggemann N, Klein C. Genetics of primary torsion dystonia. Curr Neurol Neurosci Reports 2010;10:199-206.

  32. Klein C, Djarmati A. Genetic testing in Parkinson disease – who should be assessed? Nature Reviews Neurology 2011;7:7-9.

  33. Schneider S, Klein C. Dystonic syndromes. Uncommon causes of movement disorders. Galvez-Jimenez und Tuite (Ed.), Cambridge University Press 2011; pp.121-130.

  34. Klein C, Krainc D, Schlossmacher M, Lang AE. Translational Research in Neurology and Neuroscience 2010: Movement disorders. Arch Neurol 2011;68:709-716.

  35. Schneider S, Klein C. What is the role of genetic testing in movement disorders practice? Curr Neurol Neurosci Rep 2011;11:351-361.

  36. Schneider SA, Schneider UH, Klein C. Genetic testing for neurologic disorders. Semin Neurol 2011; 31:542-552.

  37. Klein C, Münchau A. Progressive dystonia. In: Paediatric Neurology, Dulac O et al. (Ed.).

  38. Kaindl AM, Klein C. Dystonien. In: Neuropädiatrie, 4. Auflage, Aksu F (Ed.), UNI-MED Verlag, S. 306 – 318.

  39. Kumar K, Lohmann K, Klein C. Genetics of Parkinson’s disease and other movement disorders. Curr Opin Neurol, 2012:25:466-474.

  40. Grünewald A, Klein C. Parkin-associated Parkinson’s disease. Parkinson’s Disease, Chapter 14, 2nd Edition, R. Pfeifer (Hrsg.), in press.

  41. Kock N, Hedrich K, Klein C. Primary dystonia. In: Encyclopedia of Molecular Mechanisms of Disease. Lang F (Ed.), Springer, in press.

  42. Klein C and Westenberger A. Genetics of Parkinson’s disease. In: Parkinson’s Disease, Cold Spring Harbor Laboratory Press, Przedborski S (Ed.), 2012;2(1):a008888.

  43. Klein C. Genetisches Testen auf erbliche Parkinsonsyndrome. Akt Neurol, in press.

  44. Klein C. Genetics of Parkinson’s Disease. Parkinson’s Disease, in press.

  45. Klein C, Lohmann K, Ziegler A. The promise of genome-wide association studies: personalized medicine on the horizon? JAMA, im Druck.

Editorials and Book Reviews
  1. Klein C, Bonifati V. Dissecting the complexity of frontotemporal dementia: genotypes, phenotypes, and phenocopies. Editorial. Neurology 2007;69:129-130.

  2. Klein C. DYT16: A new twist to familial dystonia. Lancet Neurol 2008;7:192-193. 

  3. Klein C. Can transcranial sonography differentiate genetic from idiopathic Parkinson’s disease? Journal Watch Neurology 2007 Dez. 

  4. Klein C, Ziegler A. How to predict the risk of Parkinson’s disease in relatives of Parkin mutation carriers: A complex puzzle of age, penetrance, and number of mutated alleles. Arch Neurol 2008;65:443-444.

  5. Klein C. Introduction into the ‘Continuum on Neurogenetics’. Continuum: Lifelong Learning in Neurology. 2008;14:13-14.

  6. Klein C. ‘Parkinson’s disease: A fresh look at genetics and pathogenesis’. Buch-Rezension zu Parkinson’s Disease: Genetics and Pathogenesis. Ted Dawson (Hrsg.), Informa Healthcare 2007, Lancet Neurology, 2008.

  7. Klein C, Lohmann K. Parkinson disease(s): Is ‘Parkin disease’ a distinct clinical entity? Neurology 2009;72:106-107.

  8. Klein C, Ziegler A. From GWAS to clinical utility in Parkinson’s disease. Lancet 2011;377:613-614.

  9. Klein C. Next-generation neurogenetics: the future has begun. Semin Neurol 2011;31:431-432.

  10. Klein C, Krainc D. Movement disorders 2011: Translating new research findings into clinical practice. Nature Rev Neurol 2011;8:65-66.

  11. Orolicki S, Klein C. Elucidating novel functions of TorsinA: Elimination of misfolded proteins from the endoplasmic reticulum. Mov Disord, in press.

Website articles
  1. Klein C. The twists and turns of dystonia genes and loci: an update. Web Site Edition of the Movement Disorders Society, February/March 2009.

  2. Schneider SA, Klein C: Pink1 Type of Young-Onset Parkinson Disease (March 2010) in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2010. Available at http://www.genetests.org <http://www.genetests.org/

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