Meike Kasten
Meike Kasten, MD
Section leader
Phone number:0451 3101 7517

Current Position:

Group leader “Neuropsychiatric Epidemiology”

Research Focus:

Epidemiology of psychiatric symptoms and disorders in movement disorders

Education & Scientific training

Educucation:

1996-2002 Medical School at the Ruhr University Bochum

1998-2002 Doctoral thesis at the Department of Psychiatry and Psychotherapy, Johannes Gutenberg Universität Mainz, Topic: Examination of Body Mass Index and leptin in patients with Narcolepsy

2002-2004 Neurology residency at the Department of Neurology, University Clinic of Schleswig-Holstein, Campus Luebeck including 6 months protected research time

2006-2011 Psychiatry residency at the Department of Psychiatry and Psychotherapy, University Clinic of Schleswig-Holstein, Campus Luebeck including 6 months protected research time

March 2011 Completion of Clinical Training and Board Examination for Psychiatry and Psychotherapy

January 2012 Submission of the Habilitation thesis; University of Lübeck, Medical Faculty
“Non-motor symptoms in Parkinson disease”

Scientific Training:

2002-2004 Clinical research experience in the Neurogenetics group of Prof. Klein at the University of Lübeck

2004-2006 Neuroepidemiology Fellowship (Postdoctoral position) at the Parkinson’s Institute in Sunnyvale, California, USA

July 2004 Movement Disorders course in Aspen, Colorado (Faculty: Prof. S. Fahn, Prof. J. Jankovic, Prof. M Hallett)

„Summer class“ 2004 University of California San Francisco (UCSF); „Designing clinical research“

Summer quarter 2004 “Introduction to statistics” (HRP 259) at Stanford University, Department of Public Health and Epidemiology

Winter quarter 2004-2005 “Categorical data analysis” (HRP 261) at Stanford University

Summer quarter 2005 “Scientific Writing” at Stanford University

2006-current Active in Clinical Research within the Section of Clinical and Molecular Neurogenetics with Prof. Klein
Mentoring medical students for their dissertation

June 2010 Start of the first independent research project funded by the German Research Foundation
Awards & Memberships

Awards:

2004-2006 Two-year stipend of the Michael J. Fox Foundation

2005 Junior Scholarship Award of the Movement Disorders Society

2009 Travel grant of the Melvin Yahr Foundation to attend the “World Congress of Parkinson’s disease and Related Disorders”

2011 Poster award at the German Society of Neurology Congress

2011 Poster award at the German Society of Psychiatry, Psychotherapy and Neurology Congress

Memberships:

Movement Disorders Society (MDS)

American Academy of Neurology (AAN)

The German Association for Psychiatry and Psychotherapy (DGPPN)

Serving as Mentor for young psychiatrists in the DGPPN mentoring program

Epidemiology task force of the MDS

Web Editorial Board member of the MDS as representative for the epidemiology task force

Research Funding

Title: „Untersuchung von Familien zur genetischen Prädisposition für Bewegungsstörungen unter Neuroleptika“

Principal Investigator
Agency: University of Lübeck
Type: Research grant
Funding period: 2007-2008
Amount: 7,000€

Title: “Intermediäre Phänotypen und Biomarker in der Neurobiomedizin”

Coordinator of core project for the Lübeck site
Agency: „Medizinausschuss“
Type: Research Grant
Funding period: 2009-2010
Amount: 44,300€

Title: „Endophänotypen von Bewegungsstörungen“

Principal Investigator of Sub-project on Imaging and Coordinator of the core project for the Lübeck site
Type: Research Grant
Funding period: 2011-2012
Amount: 18,000€

Title: “Epidemiologie nicht-motorischer Symptome beim Parkinsonsyndrom: Häufigkeit, Charakteristika, Spezifität und Verlauf nicht-motorischer Symptome“

Principal Investigator: Meike Kasten (Co-PI Prof. Dr. Christine Klein and Prof. Dr. Dr. Heiner Raspe)
Type: Research grant
Agency: German Research Foundation (DFG)
Funding period: 2010-2013
Amount: 265,562€

Title “Epidemiologische und psychiatrische Untersuchungen zu Bewegungsstörungen”

Principal Investigator: Meike Kasten
Type: Career development grant
Agency: University of Lübeck
Amount: 29,500€

Publications

Selection of 5 most important publications out of 40;
cumulative impact factor: 205.1; mean 5.1

  1. Kasten M, Weichert C, Lohmann K, Klein C. Clinical and demographic characteristics of PINK1 mutation carriers--a meta-analysis. Mov Disord 2010;25:952-954.

  2. Kasten M, Kertelge L, Brüggemann N, van der Vegt J, Schmidt A, Tadic V, Buhmann C, Steinlechner S, Behrens MI, Ramirez A, Binkofski F, Siebner H, Raspe H, Hagenah J, Lencer R, Klein C. Nonmotor symptoms in genetic Parkinson disease. Arch Neurol 2010;67:670-676.

  3. Kertelge L, Brüggemann N, Schmidt A, Tadic V, Wisse C, Dankert S, Drude L, van der Vegt J, Siebner H, Pawlack H, Pramstaller PP, Behrens MI, Ramirez A, Reichel D, Buhmann C, Hagenah J, Klein C, Lohmann K, Kasten M. Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease. Mov Disord 2010;25:2665-2669.

  4. Kasten M, Brüggemann N, Konig IR, Doerry K, Steinlechner S, Wenzel L, Lohmann K, Klein C, Lencer R. Risk for antipsychotic-induced extrapyramidal symptoms: influence of family history and genetic susceptibility. Psychopharmacology (Berl) 2010;214:729-736.

  5. Kasten M, Kertelge L, Tadic V, Brüggemann N, Schmidt A, van der Vegt J, Siebner H, Buhmann C, Lencer R, Kumar KR, Lohmann K, Hagenah J, Klein C. Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson's disease. Mov Disord 2012;27:754-759.

Complete list of publications
  1. Dahmen N, Bierbrauer J, Kasten M. Increased prevalence of obesity in narcoleptic patients and relatives. Eur Arch Psychiatry Clin Neurosci 2001;251:85-89.

  2. Dahmen N, Kasten M. REM-associated hallucinations and sleep paralysis are dependent on body posture. J Neurol 2001;248:423-424.

  3. Gencik M, Dahmen N, Wieczorek S, Kasten M, Bierbrauer J, Anghelescu I, Szegedi A, Menezes Saecker AM, Epplen JT. A prepro-orexin gene polymorphism is associated with narcolepsy. Neurology 2001;56:115-117.

  4. Gencik M, Dahmen N, Wieczorek S, Kasten M, Gencikova A, Epplen JT. ApoE polymorphisms in narcolepsy. BMC Med Genet 2001;2:9.

  5. Dahmen N, Kasten M, Mittag K, Muller MJ. Narcoleptic and schizophrenic hallucinations. Implications for differential diagnosis and pathophysiology. Eur J Health Econ 2002; 3 Suppl 2:S94-98.

  6. Dahmen N, Kasten M, Muller MJ, Mittag K. Frequency and dependence on body posture of hallucinations and sleep paralysis in a community sample. J Sleep Res 2002;11:179-180.

  7. Dahmen N, Kasten M, Wieczorek S, Gencik M, Epplen JT, Ullrich B. Increased frequency of migraine in narcoleptic patients: a confirmatory study. Cephalalgia 2003;23:14-19.

  8. Wellenbrock C, Hedrich K, Schafer N, Kasten M, Jacobs H, Schwinger E, Hagenah J, Pramstaller PP, Vieregge P, Klein C. NR4A2 mutations are rare among European patients with familial Parkinson's disease. Ann Neurol 2003; 54:415.

  9. Wieczorek S, Dahmen N, Kasten M, Epplen JT, Gencik M. A rare form of narcolepsy (HLA-DR2-) shows possible association with (functionally relevant) alpha-interferon gene polymorphisms. Psychiatr Genet 2004; 14:47-51.

  10. Lencer R, Eismann G, Kasten M, Kabakci K, Geithe V, Grimm J, Klein C. Family history of primary movement disorders as a predictor for neuroleptic-induced extrapyramidal symptoms. Br J Psychiatry 2004;185:465-471.

  11. Kock N, Kasten M, Schule B, Hedrich K, Wiegers K, Kabakci K, Hagenah J, Pramstaller PP, Nitschke MF, Munchau A, Sperner J, Klein C. Clinical and genetic features of myoclonus-dystonia in 3 cases: a video presentation. Mov Disord 2004; 19:231-234.

  12. Buhmann C, Binkofski F, Klein C, Buchel C, van Eimeren T, Erdmann C, Hedrich K, Kasten M, Hagenah J, Deuschl G, Pramstaller PP, Siebner HR. Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic parkinsonism. Brain 2005; 128(Pt 10):2281-2290.

  13. Hedrich K, Pramstaller PP, Stubke K, Hiller A, Kabakci K, Purmann S, Kasten M, Scaglione C, Schwinger E, Volkmann J, Kostic V, Vieregge P, Martinelli P, Abbruzzese G, Klein C, Zuhlke C. Premutations in the FMR1 gene as a modifying factor in Parkin-associated Parkinson's disease? Mov Disord 2005; 20:1060-1062.

  14. Hedrich K, Winkler S, Hagenah J, Kabakci K, Kasten M, Schwinger E, Volkmann J, Pramstaller PP, Kostic V, Vieregge P, Klein C. Recurrent LRRK2 (Park8) mutations in early-onset Parkinson's disease. Mov Disord 2006;21:1506-1510.

  15. Chade AR, Kasten M, Tanner CM. Nongenetic causes of Parkinson's disease. J Neural Transm Suppl 2006;70:147-151.

  16. Hagenah JM, Konig IR, Becker B, Hilker R, Kasten M, Hedrich K, Pramstaller PP, Klein C, Seidel G. Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles. J Neurol 2007;254:1407-13.

  17. Reetz K, Siebner HR, Gaser C, Hagenah J, Buechel C, Kasten M, Petersen D, Pramstaller PP, Klein C, Binkofksi F. Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease. Open Neuroimag J 2008; 2:102-5.

  18. Zschiedrich K, Konig IR, Brüggemann N, Kock N, Kasten M, Leenders KL, Kostic V, Vieregge P, Ziegler A, Klein C, Lohmann K (2009) MDR1 variants and risk of Parkinson disease. Association with pesticide exposure? J Neurol 256(1):115-20. (IF 3,853)

  19. Popat RA, Van Den Eeden SK, Tanner CM, Kushida CA, Rama AN, Black JE, Bernstein A, Kasten M, Chade A, Leimpeter A, Cassidy J, McGuire V, Nelson LM. Reliability and validity of two self-administered questionnaires for screening restless legs syndrome in population-based studies. Sleep Med 2010;11:154-160.

  20. Kasten M, Weichert C, Lohmann K, Klein C. Clinical and demographic characteristics of PINK1 mutation carriers--a meta-analysis. Mov Disord 2010;25:952-954.

  21. Klebe S, Thier S, Lorenz D, Nothnagel M, Schreiber S, Klein C, Hagenah J, Kasten M, Berg D, Srulijes K, Gasser T, Deuschl G, Kuhlenbaumer G. LINGO1 is not associated with Parkinson's disease in German patients. Am J Med Genet B Neuropsychiatr Genet 2010;153B:1173-1178.

  22. Kasten M, Tadic V, Klein C. Anemia or low hemoglobin levels preceding Parkinson disease: a case-control study. Neurology 2010;74:1655.

  23. Reetz K, Tadic V, Kasten M, Brüggemann N, Schmidt A, Hagenah J, Pramstaller PP, Ramirez A, Behrens MI, Siebner HR, Klein C, Binkofski F. Structural imaging in the presymptomatic stage of genetically determined parkinsonism. Neurobiol Dis 2010;39:402-408.

  24. Eggers C, Schmidt A, Hagenah J, Brüggemann N, Klein JC, Tadic V, Kertelge L, Kasten M, Binkofski F, Siebner H, Neumaier B, Fink GR, Hilker R, Klein C. Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit. Neurology 2010;74:1798-1805.

  25. Kasten M, Brüggemann N, Schmidt A, Klein C. Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology 2010;75:478.

  26. Kasten M, Kertelge L, Brüggemann N, van der Vegt J, Schmidt A, Tadic V, Buhmann C, Steinlechner S, Behrens MI, Ramirez A, Binkofski F, Siebner H, Raspe H, Hagenah J, Lencer R, Klein C. Nonmotor symptoms in genetic Parkinson disease. Arch Neurol 2010;67:670-676.

  27. Kertelge L, Brüggemann N, Schmidt A, Tadic V, Wisse C, Dankert S, Drude L, van der Vegt J, Siebner H, Pawlack H, Pramstaller PP, Behrens MI, Ramirez A, Reichel D, Buhmann C, Hagenah J, Klein C, Lohmann K, Kasten M. Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease. Mov Disord 2010; 25:2665-9.

  28. Zittel S, Moll CK, Brüggemann N, Tadic V, Hamel W, Kasten M, Lohmann K, Lohnau T, Winkler S, Gerloff C, Schonweiler R, Hagenah J, Klein C, Munchau A, Schneider SA. Clinical neuroimaging and electrophysiological assessment of three DYT6 dystonia families. Mov Disord 2010;25:2405-2412.

  29. Brüggemann N, Hagenah J, Reetz K, Schmidt A, Kasten M, Buchmann I, Eckerle S, Bahre M, Munchau A, Djarmati A, van der Vegt J, Siebner H, Binkofski F, Ramirez A, Behrens MI, Klein C. Recessively inherited parkinsonism: effect of ATP13A2 mutations on the clinical and neuroimaging phenotype. Arch Neurol 2010;67:1357-1363.

  30. Grünewald A, Voges L, Rakovic A, Kasten M, Vandebona H, Hemmelmann C, Lohmann K, Orolicki S, Ramirez A, Schapira AH, Pramstaller PP, Sue CM, Klein C. Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS One 2010;5:e12962.

  31. Kasten M, Brüggemann N, Konig IR, Doerry K, Steinlechner S, Wenzel L, Lohmann K, Klein C, Lencer R. Risk for antipsychotic-induced extrapyramidal symptoms: influence of family history and genetic susceptibility. Psychopharmacology (Berl)2010;214:729-736.

  32. Tanner CM, Kamel F, Ross GW, Hoppin JA, Goldman SM, Korell M, Marras C, Bhudhikanok GS, Kasten M, Chade AR, Comyns K, Richards MB, Meng C, Priestley B, Fernandez HH, Cambi F, Umbach DM, Blair A, Sandler DP, Langston JW. Rotenone, paraquat, and Parkinson's disease. Environ Health Perspect 2011;119:866-872.

  33. Marras C, Schüle B, Munhoz RP, Rogaeva E, Langston JW, Kasten M, Meaney C, Klein C, Wadia PM, Lim SY, Chuang RS, Zadikof C, Steeves T, Prakash KM, de Bie RM, Adeli G, Thomsen T, Johansen KK, Teive HA, Asante A, Reginold W, Lang AE. Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers. Neurology 2011;77:325-33.

  34. Goldman SM, Quinlan PJ, Ross GW, Marras C, Meng C, Bhudhikanok GS, Comyns K, Korell M, Chade AR, Kasten M, Priestley B, Chou KL, Fernandez HH, Cambi F, Langston JW, Tanner CM. Solvent exposures and parkinson disease risk in twins. Ann Neurol 2011;71(6).

  35. Kasten M, Kertelge L, Tadic V, Brüggemann N, Schmidt A, van der Vegt J, Siebner H, Buhmann C, Lencer R, Kumar KR, Lohmann K, Hagenah J, Klein C. Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson's disease. Mov Disord 2012;27:754-759.

  36. Kumar KR, Weissbach A, Heldmann M, Kasten M, Tunc S, Sue CM, Svetel M, Kostić VS, Segura-Aguilar J, Ramirez A, Simon DK, Vieregge P, Münte TF, Hagenah J, Klein C, Lohmann K. Frequency of the D620N Mutation in VPS35 in Parkinson Disease. Arch Neurol 2012;16:1-5.

  37. Appenzeller S, Thier S, Papengut F, Klein C, Hagenah J, Kasten M, Berg D, Srulijes K, Gasser T, Schreiber S, Deuschl G, Kuhlenbäumer G.No association between NOD2 variants and Parkinson's disease. Mov Disord 2012 Jul (e-pub ahead of print).

  38. Tadic V, Kasten M, Brüggemann N, Stiller S, Hagenah J, Klein C. Dopa-responsive dystonia revisited: Diagnostic delay, residual signs, and non-motor signs. Arch Neurol, In press. 

  39. Schneider SA, Drude L, Kasten M, Klein C, Hagenah J. A study of subtle motor signs in early Parkinson’s disease. Mov Dis, In press 

  40. Weissbach A, Siegesmund K, Brüggemann N, Schmidt A, Kasten M, Pichler I, Muhle H, Lohmann E, Lohnau T, Schwinger E, Hagenah J, Stephani U, Pramstaller PP, Klein C, Lohmann, K. Exome Sequencing in a Family with Restless Legs Syndrome. Mov Dis, in press

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