Marija Dulović Mahlow, née Dulović
Marija Dulović Mahlow, née Dulović, MD, PhD
Postdoctoral Researcher
Phone number:+49 451 3101 8203

Current Position:

Postdoctoral Researcher (Genetics of Rare Diseases; Drosophila Models of Neurodegeneration)

Research Focus:

Functional characterization of novel disease-causing mutations and studying the underlying mechanisms, which are causative for movement disorders
Education & Scientific training

Education:

2000-2008 Medical studies; School of Medicine, University of Belgrade (Serbia)
Obtained medical degree (M.D.; 9.06/10.00)

2009 Six-months clinical internship; Clinical Center of Serbia (Belgrade, Serbia)
Obtained medical license

2010-2015 Doctoral thesis in Molecular medicine; University of Belgrade (Serbia), Institute of Medical and Clinical Biochemistry, School of Medicine (Director: Prof. Dr. I. Marković) and Clinical Center of Serbia, Department of neurodegenerative diseases (Director: Prof. Dr. V. S. Kostic)
Ph.D. thesis: "The role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro"
Obtained Ph.D. degree (Ph.D.; 9.60/10.00)

2012-present Specialization in Laboratory Medicine; School of Medicine, University of Belgrade (Serbia)

Scientific training & Professional Experience:

2005–2006 Medical student researcher; Department of Psychiatry, Clinical Centre of Serbia, Belgrade (Serbia)
Project: "Is there any difference in IQ among types of psychiatric disorders?"

2006–2008 Medical student researcher;  Institute of Medical and Clinical Biochemistry, School of Medicine, University of Belgrade (Serbia)
Project: "Protective role of endogenous nucleosides on primary rat astrocytes in energy depleting conditions"

2009–2011 Clinical researcher;  Institute of Medical and Clinical Biochemistry, School of Medicine, University of Belgrade (Serbia) and Ministry of Education, Science and Technological Development, Belgrade (Serbia)
Project: "Molecular mechanisms of cell death regulation at physiological and pathological conditions"

2011–2018 Clinical researcher;  Institute of Medical and Clinical Biochemistry, School of Medicine, University of Belgrade (Serbia)
Project: "Modulation of intracellularenergy balance-controlling signaling pathways in therapy of cancer andneuro-immuno-endocrine disorders"

2011–2018 Teaching Assistant;  Institute of Medical and Clinical Biochemistry, School of Medicine, University of Belgrade (Serbia)
Subject: Medical and Clinical Biochemistry
Education in Serbian and English language

2016–present Postdoctoral Researcher; Institute of Neurogenetics, University of Luebeck (Germany)

Awards & Memberships

Awards:

2011 The Best Poster Presenter Award, 5th Conference of the Serbian Society of Neuroscience, Kopaonik (Serbia)
2011 Travel grant, ISN-ESN 23rd Biennial meeting, Athens (Greece)
2011 Travel grant, SiNAPSA Neuroscience Conference ‘11, Ljubljana (Slovenia)
2011 Travel grant, DAAD Workshop: Current Methods in Neurosciences, Kotor (Montenegro)
2011 Travel grant, ICGEB theoretical Course: Mouse Genetics; Models for Human Diseases, Trieste (Italy)
2012 Travel grant, 44th International Danube Neurology Symposium, Szeged (Hungary)
2012 Travel grant, 8th FENS Forum of Neuroscience, Barcelona (Spain)
2012 The Best Abstract Award (under supervision of Dulovic M, MD PhD), 23rd European Student's Conference, Charite, Berlin, Germany
2013 The Best Abstract Award (under supervision of Dulovic M, MD PhD), 8th International Medical Students' Congress in Novi Sad (Serbia)
2013 Travel grant, FENS Regional Meeting, Prague (Czech Republic)
2013 Travel grant, The EU FP7 Glowbrain Workshop: Application of biomaterials and in vivo imaging in stem cell research, Zagreb (Croatia)
2014 Travel grant, 27th ECNP Congress, Berlin (Germany)
2014 Travel grant, COST Action BM1001: Tenascins and ECM Modulation in Plasticity and Neuroinflammation, Belgrade (Serbia)
2015 6-month Scholarship for Young Neuroscientists from the Foundation "Risto Bokonjic", Munich (Germany)
2016 2-month Universitätsklinikum SH Stipendium, Luebeck (Germany)
2016 1-year scholarship from the DAAD, Bonn (Germany)

Publications
Complete list of publications
  1. Dulovic M, Vos M. Sleep dysfunction in Parkinson’s disease: novel molecular mechanism and implications for therapy. Mov Disord. 2018; 33(10):1558-1559.

  2. Seibler P*, Burbulla LF*, Dulovic M* (equally contributing frst author), Zittel S, Heine J, Schmidt T, Rudolph F, Westenberger A, Rakovic A, Münchau A, Krainc D, Klein C. Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells. Brain. 2018; 141(10):3052-3064.

  3. Dulovic M,  Schäffer E, Leypoldt F, Balck A, Schaake S, Hinrichs F, Kirchner H, Brüggemann N, Berg D, Lohmann K. A Klinefelter patient with an additional mitochondrial mutation: Implications for genotype-driven treatment and mitochondrial mutational load in different tissues and family members. Parkinsonism Relat Disord. 2018; 54:116-118.

  4. Kasten M, Hartmann C, Hampf J, Schaake S, Westenberger A, Vollstedt EJ, Balck A, Domingo A, Vulinovic F, Dulovic M, Zorn I, Madoev H, Zehnle H, Lembeck CM, Schawe L, Reginold J, Huang J, König IR, Bertram L, Marras C, Lohmann K, Lill CM, Klein C. Genotype-Phenotype Relations for the Parkinson’s Disease Genes Parkin, PINK1, DJ1:MDSGene Systematic Review. Mov Disord. 2018; 33(5):730-741.

  5. Seong E, Insolera R, Dulovic M, Kamsteeg EJ, Trinh J, Brüggemann N, Sandford E, Li S, Ozel AB, Li JZ, Jewett T, Kievit AJA, Münchau A, Shakkottai V, Klein C, Collins C, Lohmann K, van de Warrenburg BP, Burmeister M. Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects. Ann Neurol. 2018; 83(6):1075-1088.

  6. Isakovic AM, Dulovic M, Markovic I, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V, Isakovic A. Autophagy suppression sensitizes glioma cells to IMP dehydrogenase inhibition-induced apoptotic death. Exp Cell Res. 2017; 350(1):32-40.

  7. Djuranovic A, Jeremic M, Zogovic N, Tovilovic-Kovacevic G, Dulovic M. The role of autophagy in alpha-synuclein neurotoxicity in SH-SY5Y human neuroblastoma cells. Medical Youth. 2016; 67(4):47-53.

  8. Jeremic M, Radeta R, Dulovic M. The role of AMPK in neurotoxic effect of modifed forms of recombinant alpha-synuclein in vitro.Medical Youth. 2016; 67(1):51-57.

  9. Todorovic T, Grubisic S, Pregelj M, Jagodic M, Misirlic-Dencic S, Dulovic M, Markovic I, Klisuric O, Malesevic A, Mitic D, Anelkovic K, Filipovic N. Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear CuII Complexes with Bidentate N-Heteroaromatic Schiff Base Ligands. Eur. J. Inorg. Chem. 2015; 3921–3931.

  10. Filipovic N , Polovic N, Raskovic B, Misirlic-Dencic S, Dulovic M, Savic M, Niksic M, Mitic D, Andjelkovic K, Todorovic T. Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes. Monatshefte Fur Chemie 2014; 145(7):1089-1099.

  11. Savić A, Misirlić-Denčić S, Dulović M, Mihajlović-Lalić LE, Jovanović M, Grgurić-Šipka S, Marković I, Sabo TJ. Synthesis, characterization and ROS-mediated cytotoxic action of novel (S,S)-1,3-propanediamineN,N’-di-2-(3-cyclohexyl)propanoic acid and corresponding esters. Bioorg Chem. 2014; 54:73-80.

  12. Filipović N, Marković I, Mitić D, Polović N, Milčić M, Dulović M, Jovanović M, Savić M, Nikšić M, Anđelković K, Todorović T. A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt(II), Zn(II), Cu(II), and Co(III) Complexes with N-heteroaromatic Schiff Base (E)-2-[N’-(1-pyridin-2-yl-ethylidene)hydrazino]acetate. J Biochem Mol Toxicol. 2014; 28(3):99-110.

  13. Filipovic N, Grubisic S, Jovanovic M, Dulovic M, Markovic I, Klisuric O, Marinkovic A, Mitic D, Andelkovic K, Todorovic T. Palladium(II) complexes with N-heteroaromatic bidentate hydrazone ligands: the effect of the chelate ring size and lipophilicity on in vitro cytotoxic activity. Chem Biol Drug Des. 2014; 84(3):333-41.

  14. Dulovic M, Jovanovic M, Xilouri M, Stefanis L, Harhaji-Trajkovic L, Kravic-Stevovic T, Paunovic V, Ardah MT, El-Agnaf OM, Kostic V, Markovic I, Trajkovic V. The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro. Neurobiol Dis. 2014; 63:1-11.

  15. Dulović M, Jovanović M. Protein degradation mechanisms in neurodegenerative diseases. Sinapsa. 2013; 7&8: 18-23.

  16. Radeta R, Vidičević S, Dulovic M. The role of PI3K/Akt signaling pathway in Parkinson’s disease, in vitro. Medical Youth. 2013; 64(1-2):104-113.

  17. Tovilovic G, Ristic B, Siljic M, Nikolic V, Kravic-Stevovic T, Dulovic M, Milenkovic M, Knezevic A, Bosnjak M, Bumbasirevic V, Stanojevic M, Trajkovic V. mTOR-independent autophagy counteracts apoptosis in herpes simplex virus type 1-infected U251 glioma cells. Microbes Infect. 2013; 15(8-9):615-24.

  18. Misirlic Dencic S, Poljarevic J, Vilimanovich U, Bogdanovic A, Isakovic AJ, Kravic Stevovic T, Dulovic M, Zogovic N, Isakovic AM, Grguric-Sipka S, Bumbasirevic V, Sabo T, Trajkovic V, Markovic I. Cyclohexyl Analogues of Ethylenediamine Dipropanoic Acid Induce Caspase-Independent Mitochondrial Apoptosis in Human Leukemic Cells. Chem Res Toxicol. 2012; 25(4):931-9.

  19. Savić A*, Dulović M* (equally contributing frst author), Poljarević JM, Misirlić-Denčić S, Jovanović M, Bogdanović A, Trajković V, Sabo TJ, Grgurić-Šipka S, Marković I. Synthesis and in vitro Anticancer Activity of Ruthenium-Cymene Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N’-diacetate-Type Ligands. ChemMedChem. 2011; 6(10):1884-91.

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