Modifier of disease severity and cognitive dysfunction in X-linked dystonia-parkinsonism identified

Members of the Institute of Neurogenetics in collaboration with other members of the “ProtectMove” Consortium (funded by the German Research Foundation, DFG FOR2488) have recently identified a novel modifier of disease severity and cognitive dysfunction in X-linked dystonia-parkinsonism. This study was published in Annals of Neurology, one of the five leading "Clinical Neurology" journals in the world.


The elucidation of genetic factors that influence disease expressivity (onset, type, and severity of symptoms) holds enormous translational potential and is thus of utmost importance for patients affected by severe hereditary disorders.


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